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View Structure Prediction Details

Protein: BUB2
Organism: Saccharomyces cerevisiae
Length: 306 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for BUB2.

Description E-value Query
Range
Subject
Range
gi|3093476 - gi|3093476|gb|AAC16031.1| EVI-5 homolog [Homo sapiens]
4.0E-57 [4..300] [127..425]
gi|74143478, gi|... - gi|85861226|ref|NP_080044.2| GH regulated TBC protein 1 [Mus musculus], gi|74143478|dbj|BAE28813.1| ...
1.0E-55 [7..286] [48..315]
BUB2 - Mitotic exit network regulator, forms GTPase-activating Bfa1p-Bub2p complex that binds Tem1p and spi...
gi|151946214 - gi|151946214|gb|EDN64445.1| budding uninhibited by benzimidazole-related protein [Saccharomyces cere...
BUB2_YEAST - Mitotic check point protein BUB2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=BUB2 PE...
3.0E-54 [1..306] [1..306]

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Predicted Domain #1
Region A:
Residues: [1-172]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTSIEDLISN PPLLLHSSLS QLRYLILSEG LPISEDKQQQ RTRCYVWTVL SQTSMEASTQ  60
   61 RYLALLKLGP PSTTIYQKIK NDTSRTFQTD PNFRNRVSED ALIRCLSCFA WQTQQRRQKT 120
  121 RFGRIPVSTY VQGMNVLLAP LLYSCPSEPM AYQLFTKLCY EMIPTYLTKN LN

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [226-234]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KLWDFMFAY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 33.0
Match: 1fkmA_
Description: Ypt/Rab-GAP domain of gyp1p
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [173-225]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GAQNGAKLLD ISLRIIDPKL SKFLSDNLLT AEIYGMPSIL TLSSCNKPLD QVI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 33.0
Match: 1fkmA_
Description: Ypt/Rab-GAP domain of gyp1p
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [235-306]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GFHMNILFVV AFLVKMRSKV FKSDSPVNLL RQFPDFDADE IIRLGVGFIA KIPAQIYDLL  60
   61 VDHLTDPDIY IP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.508 a.4.5 "Winged helix" DNA-binding domain
View Download 0.428 a.35.1 lambda repressor-like DNA-binding domains
View Download 0.437 a.16.1 S15/NS1 RNA-binding domain
View Download 0.396 a.65.1 Annexin
View Download 0.394 a.4.9 Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3
View Download 0.392 a.4.1 Homeodomain-like
View Download 0.385 a.4.1 Homeodomain-like
View Download 0.348 a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.343 a.4.6 C-terminal effector domain of the bipartite response regulators
View Download 0.320 a.4.5 "Winged helix" DNA-binding domain
View Download 0.319 a.4.6 C-terminal effector domain of the bipartite response regulators
View Download 0.312 a.100.1 6-phosphogluconate dehydrogenase C-terminal domain-like
View Download 0.311 a.118.1 ARM repeat
View Download 0.304 a.4.1 Homeodomain-like
View Download 0.303 a.21.1 HMG-box
View Download 0.293 a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.288 a.64.1 Saposin
View Download 0.286 a.12.1 Kix domain of CBP (creb binding protein)
View Download 0.281 a.46.2 Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain
View Download 0.279 a.4.6 C-terminal effector domain of the bipartite response regulators
View Download 0.273 a.77.1 DEATH domain
View Download 0.266 a.138.1 Multiheme cytochromes
View Download 0.263 a.4.1 Homeodomain-like
View Download 0.262 a.76.1 Iron-dependent represor protein, dimerization domain
View Download 0.243 a.4.5 "Winged helix" DNA-binding domain
View Download 0.242 a.77.1 DEATH domain
View Download 0.241 a.151.1 Glutamyl tRNA-reductase dimerization domain
View Download 0.235 a.51.1 Cytochrome c oxidase subunit h
View Download 0.229 d.78.1 RPB5-like RNA polymerase subunit
View Download 0.229 a.58.1 Chemotaxis receptor methyltransferase CheR, N-terminal domain
View Download 0.225 i.1.1 Ribosome and ribosomal fragments
View Download 0.225 a.37.1 A DNA-binding domain in eukaryotic transcription factors
View Download 0.224 a.4.12 TrpR-like
View Download 0.222 a.21.1 HMG-box
View Download 0.222 a.4.5 "Winged helix" DNA-binding domain
View Download 0.216 a.11.1 Acyl-CoA binding protein
View Download 0.214 a.4.13 Sigma3 and sigma4 domains of RNA polymerase sigma factors
View Download 0.209 a.5.1 DNA helicase RuvA subunit, C-terminal domain
View Download 0.202 a.64.1 Saposin
View Download 0.200 a.23.4 Mitochondrial import receptor subunit Tom20


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle