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View Structure Prediction Details

Protein: BUB2
Organism: Saccharomyces cerevisiae
Length: 306 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for BUB2.

Description E-value Query
Range
Subject
Range
gi|3093476 - gi|3093476|gb|AAC16031.1| EVI-5 homolog [Homo sapiens]
4.0E-57 [4..300] [127..425]
gi|74143478, gi|... - gi|85861226|ref|NP_080044.2| GH regulated TBC protein 1 [Mus musculus], gi|74143478|dbj|BAE28813.1| ...
1.0E-55 [7..286] [48..315]
BUB2 - Mitotic exit network regulator, forms GTPase-activating Bfa1p-Bub2p complex that binds Tem1p and spi...
gi|151946214 - gi|151946214|gb|EDN64445.1| budding uninhibited by benzimidazole-related protein [Saccharomyces cere...
BUB2_YEAST - Mitotic check point protein BUB2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=BUB2 PE...
3.0E-54 [1..306] [1..306]

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Predicted Domain #1
Region A:
Residues: [1-172]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTSIEDLISN PPLLLHSSLS QLRYLILSEG LPISEDKQQQ RTRCYVWTVL SQTSMEASTQ  60
   61 RYLALLKLGP PSTTIYQKIK NDTSRTFQTD PNFRNRVSED ALIRCLSCFA WQTQQRRQKT 120
  121 RFGRIPVSTY VQGMNVLLAP LLYSCPSEPM AYQLFTKLCY EMIPTYLTKN LN

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [226-234]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KLWDFMFAY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 33.0
Match: 1fkmA_
Description: Ypt/Rab-GAP domain of gyp1p
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [173-225]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GAQNGAKLLD ISLRIIDPKL SKFLSDNLLT AEIYGMPSIL TLSSCNKPLD QVI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 33.0
Match: 1fkmA_
Description: Ypt/Rab-GAP domain of gyp1p
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [235-306]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GFHMNILFVV AFLVKMRSKV FKSDSPVNLL RQFPDFDADE IIRLGVGFIA KIPAQIYDLL  60
   61 VDHLTDPDIY IP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle