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View Structure Prediction Details

Protein: TUB3
Organism: Saccharomyces cerevisiae
Length: 445 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TUB3.

Description E-value Query
Range
Subject
Range
TBA1C_MOUSE - Tubulin alpha-1C chain OS=Mus musculus GN=Tuba1c PE=1 SV=1
gi|124481732, gi... - gi|148225011|ref|NP_001091315.1| hypothetical protein LOC100037141 [Xenopus laevis], gi|124481732|gb...
TBA1C_CRIGR - Tubulin alpha-1C chain OS=Cricetulus griseus GN=TUBA1C PE=2 SV=1
0.0 [1..444] [1..443]
gi|114644941 - gi|114644941|ref|XP_001158840.1| PREDICTED: tubulin alpha 6 isoform 1 [Pan troglodytes]
gi|123990474, gi... - gi|123999316|gb|ABM87234.1| tubulin, alpha 6 [synthetic construct], gi|123990474|gb|ABM83912.1| tubu...
TUBA1C - tubulin, alpha 1c
0.0 [1..444] [1..443]
TBA_XENLA - Tubulin alpha chain OS=Xenopus laevis GN=tuba PE=2 SV=2
0.0 [1..444] [1..443]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [1..441] [1..440]
gi|447739 - gi|447739|prf||1915304A nylB upstream ORF
0.0 [1..441] [1..440]
gi|35902919, gi|... - gi|35902919|ref|NP_919369.1| tubulin, alpha 1 [Danio rerio], gi|2599500|gb|AAB84143.1| alpha-tubulin...
0.0 [1..444] [1..443]
TBA_TORMA - Tubulin alpha chain OS=Torpedo marmorata PE=2 SV=1
0.0 [1..441] [1..440]

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Predicted Domain #1
Region A:
Residues: [1-445]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MREVISINVG QAGCQIGNAC WELYSLEHGI KEDGHLEDGL SKPKGGEEGF STFFHETGYG  60
   61 KFVPRAIYVD LEPNVIDEVR TGRFKELFHP EQLINGKEDA ANNYARGHYT VGREIVDEVE 120
  121 ERIRKMADQC DGLQGFLFTH SLGGGTGSGL GSLLLENLSY EYGKKSKLEF AVYPAPQLST 180
  181 SVVEPYNTVL TTHTTLEHAD CTFMVDNEAI YDICKRNLGI SRPSFSNLNG LIAQVISSVT 240
  241 ASLRFDGSLN VDLNEFQTNL VPYPRIHFPL VSYAPILSKK RATHESNSVS EITNACFEPG 300
  301 NQMVKCDPTK GKYMANCLLY RGDVVTRDVQ RAVEQVKNKK TVQMVDWCPT GFKIGICYEP 360
  361 PSVIPSSELA NVDRAVCMLS NTTAIADAWK RIDQKFDLMY AKRAFVHWYV GEGMEEGEFT 420
  421 EAREDLAALE RDYIEVGADS YAEEF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11000.0
Match: 1ffxA_
Description: Tubulin:stathmin-like domain complex
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
structural constituent of cytoskeleton 4.89410373995712 bayes_pls_golite062009
structural molecule activity 4.16877499797638 bayes_pls_golite062009
tubulin binding 2.4432045213385 bayes_pls_golite062009
cytoskeletal protein binding 2.24606230377981 bayes_pls_golite062009
binding 1.95582292281451 bayes_pls_golite062009
GTPase activity 1.87512665946067 bayes_pls_golite062009
nucleoside-triphosphatase activity 1.77500173070686 bayes_pls_golite062009
pyrophosphatase activity 1.7017047947554 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 1.68267378160702 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 1.68038087466376 bayes_pls_golite062009
protein binding 1.60795853516357 bayes_pls_golite062009
MHC class I protein binding 1.46574865275013 bayes_pls_golite062009
gamma-tubulin binding 1.02742779831447 bayes_pls_golite062009
hydrolase activity 0.502038132260603 bayes_pls_golite062009
GTP binding 0.497195442717678 bayes_pls_golite062009
guanyl ribonucleotide binding 0.47649264826419 bayes_pls_golite062009
guanyl nucleotide binding 0.468397101803116 bayes_pls_golite062009
receptor binding 0.00945891657658993 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle