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View Structure Prediction Details

Protein: MDM1
Organism: Saccharomyces cerevisiae
Length: 1127 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MDM1.

Description E-value Query
Range
Subject
Range
MDM1 - Intermediate filament protein, required for nuclear and mitochondrial transmission to daughter buds;...
MDM1_YEAST - Structural protein MDM1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MDM1 PE=1 SV=3
0.0 [1..1127] [1..1127]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [23..1107] [41..1103]
snx12 - sorting nexin Snx12
SNX12_SCHPO - Sorting nexin-12 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=snx12 PE=3 SV=1
0.0 [7..1123] [7..999]
gi|19527695 - gi|19527695|gb|AAL89962.1| AT01932p [Drosophila melanogaster]
0.0 [9..1122] [60..1004]
gi|3882147 - gi|3882147|dbj|BAA34433.1| KIAA0713 protein [Homo sapiens]
0.0 [4..575] [81..576]

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Predicted Domain #1
Region A:
Residues: [1-80]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPKFPQFRLI LVLFYLISMI QWSVITFSLG FFLNVCIFAY FVFFKSLPDL PKPQPRFVDI  60
   61 VPESSNTVDV DKELKSVEGL 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [81-294]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IQDGNAQIGK ELESIVNLII KDFVQPWFTK IDKNSDAEFL KVIKWRLLQT LLVVKDKLMK  60
   61 NDSASLIVLK LLPIFNKHFS TFCDAREAVL SDLTLERHKS ANIDLQIAVE FNKNYKIHKS 120
  121 LSLKPNALQK EIEKSIRKTV IGLLPHLFDN DELDSLLVFT LMTEVLTTCI ISPLIFKFTD 180
  181 PDSWNLRIVS LSQNYFEEKH KVHKIRRMLS KELQ

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 97.568636
Match: PF02194
Description: PXA domain

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [295-388]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DHRKVMNDVA NKDVGEPSSE KLELNAEYTG KQFEHYLNQL DSLLDLSDIK YVAYSLALKI  60
   61 YQLKENEHLT KENLKYKKRL LLSLNLIESK LSFP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.906 0.010 mitochondrion inheritance a.7.6 Ribosomal protein S20

Predicted Domain #4
Region A:
Residues: [389-607]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GSEIDTASKK LAREANYPDL NMDNGIVLKE MASFLTSITL KDIVDDSEFL PFFESFLGSV  60
   61 PETQGSTFLE YSQTIESFKN PLEDATSEDI ISGYSGISTM QLQEISSKFF HNNNLQNMKL 120
  121 LDEGLVKNII LFRNSFQINN DEDTFILARK SVLLLQTEAI KYLDDRFLPL FKKTPSFLKM 180
  181 LSTSHIISTD IYAHFLSRIG GVNNPEQNKI IKDNVKTDF

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 12.29
Match: 1agrE
Description: Regulator of G-protein signalling 4, RGS4
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 1.74066926539061 bayes_pls_golite062009
protein binding 1.46874099847386 bayes_pls_golite062009
nucleoside-triphosphatase regulator activity 0.751540543950607 bayes_pls_golite062009
GTPase regulator activity 0.726313915060022 bayes_pls_golite062009
enzyme regulator activity 0.619424511001805 bayes_pls_golite062009
enzyme activator activity 0.423538625413241 bayes_pls_golite062009
GTPase activator activity 0.380332469241193 bayes_pls_golite062009
calmodulin binding 0.144645492942361 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [608-696]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNPVRIFANP GITDALDNIV NGSGSKPHKS RISSNPRYSQ LFGSENDNIF KDKLFDDEND  60
   61 NTSEISVVED QLDHPRNMEK VSVSSGNSG

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.392 0.882 mitochondrion inheritance a.39.1 EF-hand

Predicted Domain #6
Region A:
Residues: [697-920]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LNPSQFYGSN NFRDNIASLT ISIDQIEKEL ELLRHLILKA DLTNNQMQLK ILKKSQRTLL  60
   61 KELEMKELLK QQYMVQENGN SLFRKTKIYI RSYFSENSSN GLKEITYYII NIHHFNNGQV 120
  121 SSWDMARRYN EFFELNTYLK KNFRDLMRQL QDLFPSKVKM SLKYHVTKTL LYEERKQKLE 180
  181 KYLRELLSIS EICEDNIFRR FLTDPTPFKL NKEYMHDDIL EEPL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 22.154902
Match: 1h6hA_
Description: p40phox NADPH oxidase
Matching Structure (courtesy of the PDB):

Predicted Domain #7
Region A:
Residues: [921-1127]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HEPIGSSNST SNSSSVVDLQ SSEDGGELNF YEDERHFFTD SGYPFYSQNK SFVKQICDLF  60
   61 ISLFALNKAN AGWLRGRAII TVLQQLLGST IEKYIKVSIQ KLRSEDQVFE AIVTFKNMLW 120
  121 GDNGLFERKR NETAEATRSE GERLRTEQLA LTSLQRLFAD TCGRVVGLRD SHEAAGRVHA 180
  181 MLQNPYLNAS LLLEALDAIL LDIICND

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle