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View Structure Prediction Details

Protein: SRC1
Organism: Saccharomyces cerevisiae
Length: 834 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SRC1.

Description E-value Query
Range
Subject
Range
SRC1_YEAST - Inner nuclear membrane protein SRC1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SRC1...
SRC1 - Inner nuclear membrane protein that functions in regulation of subtelomeric genes and is linked to T...
0.0 [1..834] [1..834]
mug61 - Sad1 interacting factor
MUG61_SCHPO - Meiotically up-regulated gene 61 protein OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=m...
0.0 [7..819] [6..836]
gi|6473492 - gi|6473492|dbj|BAA87142.1| Hypothetical protein [Schizosaccharomyces pombe]
2.0E-56 [619..818] [1..199]
gi|1160355 - gi|1160355|gb|AAB00542.1| UNC-89
5.0E-46 [15..449] [1339..1808]
gi|189442432 - gi|189442432|gb|AAI67864.1| LEM domain containing 3 [synthetic construct]
LEMD3 - LEM domain containing 3
8.0E-44 [679..820] [610..750]

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Predicted Domain #1
Region A:
Residues: [1-149]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNSDLEYLED GFDPNSMKVA TLRRILVENN VDFPSNARKN ALVGLFDEKV KPQIPQLRKM  60
   61 YLNVRPSDEG IVKMDRPSSS PSIASPRRSR RARREKSASP MAKQFKKNRI LDDVSNDDDD 120
  121 DDDDDDDNDK KDDPLIVPSG TDTDEVDDE

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [150-436]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EDDVITSSSN KSDTNDFQQN SDTRKKRKDP DSDDWSESNS KENKIDNKHL NLLSSDSEIE  60
   61 QDYQKAKKRK TSDLNQEHGN GSAILGKLSV KTPIKNTNRK PVSMDNFNDS LTSSGTENDP 120
  121 FVPNIRHNPK ELGTANGTGH STPLSKLKVS ASFADKLPQK EVPSTILVPE VEQQEPSQSE 180
  181 RTPSLFSSEG SGSESEAPLL PEITTPGPHQ PMGNTSNNVV EMIDTDSSNL VSDEDEVLVP 240
  241 TRIETPQLPT EKDVEKCEAR VQELQEEVNE QLEHENGSEF DVKQGSG

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 7.17
Match: 1iu4A
Description: Microbial transglutaminase
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [437-678]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KVGNRHKFKR ALKFLSKSLL ALFLFCIFIV IPLLFGLWYR EQRLLIGYCG HEVPSHRVSG  60
   61 NSFEFIQKLD NLLQDYRPKC IPCPPNGICY PYLKLKCKPD YKLAPSRLDF LEIIPAQGKC 120
  121 VKDDKKQQLV SEVVEKSLEF LRAKNAQISC GDGKDDIESG MTEDALYQIF NEARAPWIRD 180
  181 DEFEDLWIQV IKDLTEEPEI LWRQLSPTDN NIGGNSNNII KTNDVPRQKR HLPEKFISKT 240
  241 RN

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [679-834]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FRSTSKKYIG MKCRFEREIY QTYKKFQRPI WLMFLLIVIS KVIEIKLKNY YRKKARIEEL  60
   61 VTQTMEKLKF QKIKSMSDPK ENAYLSIVQL RDIFLSDIVD LKYKNQLWSE VVKYLEHNNS 120
  121 NIKSNLTEIR GEIMKCWEWI GPMELNEPKD SAENKI

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.800 N/A N/A a.7.1 Spectrin repeat
View Download 0.661 N/A N/A a.7.1 Spectrin repeat
View Download 0.644 N/A N/A a.7.4 Smac/diablo
View Download 0.609 N/A N/A a.24.17 Group V grass pollen allergen
View Download 0.591 N/A N/A c.58.1 Aminoacid dehydrogenase-like, N-terminal domain
View Download 0.571 N/A N/A a.1.1 Globin-like
View Download 0.560 N/A N/A a.22.1 Histone-fold
View Download 0.550 N/A N/A a.24.4 Hemerythrin
View Download 0.525 N/A N/A a.63.1 Apolipophorin-III
View Download 0.518 N/A N/A f.1.1 Colicin
View Download 0.480 N/A N/A d.19.1 MHC antigen-recognition domain
View Download 0.457 N/A N/A a.90.1 Transcription factor STAT-4 N-domain
View Download 0.450 N/A N/A a.74.1 Cyclin-like
View Download 0.437 N/A N/A a.59.1 PAH2 domain
View Download 0.437 N/A N/A d.38.1 Thioesterase/thiol ester dehydrase-isomerase
View Download 0.436 N/A N/A c.95.1 Thiolase-like
View Download 0.432 N/A N/A a.78.1 Fatty acid responsive transcription factor FadR, C-terminal domain
View Download 0.429 N/A N/A c.2.1 NAD(P)-binding Rossmann-fold domains
View Download 0.417 N/A N/A d.221.1 Nuclease A inhibitor (NuiA)
View Download 0.408 N/A N/A a.182.1 GatB/YqeY domain
View Download 0.401 N/A N/A d.58.26 GHMP Kinase, C-terminal domain
View Download 0.401 N/A N/A a.118.12 Ran-GTPase activating protein 1 (RanGAP1), C-terminal domain
View Download 0.399 N/A N/A c.1.17 Quinolinic acid phosphoribosyltransferase (Nicotinate-nucleotide pyrophosphorylase, NadC), C-terminal domain
View Download 0.397 N/A N/A c.37.1 P-loop containing nucleoside triphosphate hydrolases
View Download 0.395 N/A N/A f.35.1 Multidrug efflux transporter AcrB transmembrane domain
View Download 0.394 N/A N/A d.43.1 Elongation factor Ts (EF-Ts), dimerisation domain
View Download 0.387 N/A N/A a.77.1 DEATH domain
View Download 0.386 N/A N/A a.62.1 Hepatitis B viral capsid (hbcag)
View Download 0.385 N/A N/A a.126.1 Serum albumin-like
View Download 0.384 N/A N/A a.1.1 Globin-like
View Download 0.382 N/A N/A d.24.1 Pili subunits
View Download 0.376 N/A N/A a.26.1 4-helical cytokines
View Download 0.376 N/A N/A b.26.1 SMAD/FHA domain
View Download 0.366 N/A N/A f.1.4 Bcl-2 inhibitors of programmed cell death
View Download 0.361 N/A N/A c.37.1 P-loop containing nucleoside triphosphate hydrolases
View Download 0.353 N/A N/A a.60.10 Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain
View Download 0.352 N/A N/A a.19.1 Fertilization protein
View Download 0.351 N/A N/A a.48.2 Transferrin receptor ectodomain, C-terminal domain
View Download 0.345 N/A N/A a.118.1 ARM repeat
View Download 0.344 N/A N/A a.26.1 4-helical cytokines
View Download 0.343 N/A N/A d.129.3 Bet v1-like
View Download 0.335 N/A N/A c.23.1 CheY-like
View Download 0.333 N/A N/A d.109.1 Actin depolymerizing proteins
View Download 0.331 N/A N/A e.37.1 Bifunctional dehydrogenase/ferrochelatase Met8p, dimerisation and C-terminal domains
View Download 0.328 N/A N/A a.1.1 Globin-like
View Download 0.326 N/A N/A a.2.7 tRNA-binding arm
View Download 0.324 N/A N/A c.108.1 HAD-like
View Download 0.323 N/A N/A d.81.1 Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain
View Download 0.322 N/A N/A a.111.1 Acid phosphatase/Vanadium-dependent haloperoxidase
View Download 0.301 N/A N/A c.28.1 Cryptochrome/photolyase, N-terminal domain
View Download 0.300 N/A N/A a.39.2 Insect pheromon/odorant-binding proteins
View Download 0.299 N/A N/A a.79.1 Antitermination factor NusB
View Download 0.298 N/A N/A d.208.1 MTH1598-like
View Download 0.293 N/A N/A a.118.9 ENTH/VHS domain
View Download 0.292 N/A N/A c.2.1 NAD(P)-binding Rossmann-fold domains
View Download 0.291 N/A N/A a.47.2 t-snare proteins
View Download 0.289 N/A N/A a.47.2 t-snare proteins
View Download 0.286 N/A N/A f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.282 N/A N/A a.25.1 Ferritin-like
View Download 0.281 N/A N/A a.2.5 Prefoldin
View Download 0.277 N/A N/A a.29.2 Bromodomain
View Download 0.276 N/A N/A d.58.31 Methyl-coenzyme M reductase subunits
View Download 0.275 N/A N/A a.118.8 TPR-like
View Download 0.262 N/A N/A b.111.1 Small protein B (SmpB)
View Download 0.258 N/A N/A a.118.11 Cytochrome c oxidase subunit E
View Download 0.256 N/A N/A f.35.1 Multidrug efflux transporter AcrB transmembrane domain
View Download 0.253 N/A N/A d.58.26 GHMP Kinase, C-terminal domain
View Download 0.252 N/A N/A d.131.1 DNA clamp
View Download 0.247 N/A N/A a.133.1 Phospholipase A2, PLA2
View Download 0.246 N/A N/A a.47.1 STAT
View Download 0.239 N/A N/A d.110.4 SNARE-like
View Download 0.235 N/A N/A f.1.4 Bcl-2 inhibitors of programmed cell death
View Download 0.233 N/A N/A a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.231 N/A N/A a.87.1 DBL homology domain (DH-domain)
View Download 0.230 N/A N/A a.123.1 Nuclear receptor ligand-binding domain
View Download 0.221 N/A N/A a.100.1 6-phosphogluconate dehydrogenase C-terminal domain-like
View Download 0.221 N/A N/A a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.220 N/A N/A a.41.1 Domain of poly(ADP-ribose) polymerase
View Download 0.220 N/A N/A d.58.19 Bacterial exopeptidase dimerisation domain
View Download 0.218 N/A N/A a.74.1 Cyclin-like
View Download 0.217 N/A N/A a.7.5 Tubulin chaperone cofactor A
View Download 0.217 N/A N/A a.5.4 Elongation factor TFIIS domain 2
View Download 0.214 N/A N/A a.91.1 Regulator of G-protein signalling, RGS
View Download 0.211 N/A N/A d.153.1 N-terminal nucleophile aminohydrolases (Ntn hydrolases)
View Download 0.211 N/A N/A f.32.1 a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)
View Download 0.209 N/A N/A a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.207 N/A N/A a.39.1 EF-hand
View Download 0.207 N/A N/A f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.202 N/A N/A d.52.2 GMP synthetase C-terminal dimerisation domain
View Download 0.202 N/A N/A a.74.1 Cyclin-like
View Download 0.202 N/A N/A a.69.2 Ypt/Rab-GAP domain of gyp1p


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle