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View Structure Prediction Details

Protein: HMG2
Organism: Saccharomyces cerevisiae
Length: 1045 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HMG2.

Description E-value Query
Range
Subject
Range
HMG2 - One of two isozymes of HMG-CoA reductase that convert HMG-CoA to mevalonate, a rate-limiting step in...
HMDH2_YEAST - 3-hydroxy-3-methylglutaryl-coenzyme A reductase 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / ...
0.0 [1..1045] [1..1045]
HMDH_RABIT - 3-hydroxy-3-methylglutaryl-coenzyme A reductase OS=Oryctolagus cuniculus GN=HMGCR PE=3 SV=1
0.0 [179..1038] [52..888]
gi|223946 - gi|223946|prf||1005248A reductase,HMG CoA
gi|387052, gi|49648 - gi|49648|emb|CAA25189.1| HMG CoA reductase [Mesocricetus auratus], gi|387052|gb|AAA36989.1| 3-hydrox...
HMDH_CRIGR - 3-hydroxy-3-methylglutaryl-coenzyme A reductase OS=Cricetulus griseus GN=HMGCR PE=1 SV=1
0.0 [179..1038] [52..887]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [179..1038] [52..887]
HMDH_MESAU - 3-hydroxy-3-methylglutaryl-coenzyme A reductase OS=Mesocricetus auratus GN=HMGCR PE=1 SV=1
0.0 [179..1038] [52..887]
HMGCR - 3-hydroxy-3-methylglutaryl-CoA reductase
0.0 [179..1038] [52..888]
HMDH_XENLA - 3-hydroxy-3-methylglutaryl-coenzyme A reductase OS=Xenopus laevis GN=hmgcr PE=2 SV=1
0.0 [175..1038] [48..883]
HMDH_CYBJA - 3-hydroxy-3-methylglutaryl-coenzyme A reductase OS=Cyberlindnera jadinii GN=HMG PE=2 SV=1
0.0 [77..1023] [3..931]
HMDH_ASPTE - 3-hydroxy-3-methylglutaryl-coenzyme A reductase (EC 1.1.1.34) (HMG-CoA reductase) - Aspergillus terr...
0.0 [7..1038] [12..1031]

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Predicted Domain #1
Region A:
Residues: [1-66]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLPLKTIVH LVKPFACTAR FSARYPIHVI VVAVLLSAAA YLSVTQSYLN EWKLDSNQYS  60
   61 TYLSIK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.793 a.65.1 Annexin
View Download 0.770 a.65.1 Annexin
View Download 0.679 a.44.1 Disulphide-bond formation facilitator (DSBA), insertion domain
View Download 0.530 a.65.1 Annexin
View Download 0.527 a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.525 a.77.1 DEATH domain
View Download 0.523 a.4.5 "Winged helix" DNA-binding domain
View Download 0.507 a.4.5 "Winged helix" DNA-binding domain
View Download 0.487 a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.481 a.4.1 Homeodomain-like
View Download 0.448 a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.448 a.65.1 Annexin
View Download 0.419 a.60.11 Hypothetical protein YjbJ
View Download 0.417 a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.416 a.4.5 "Winged helix" DNA-binding domain
View Download 0.416 a.153.1 Nuclear receptor coactivator interlocking domain
View Download 0.402 a.4.5 "Winged helix" DNA-binding domain
View Download 0.388 a.48.3 Conserved domain common to transcription factors TFIIS, elongin A, CRSP70
View Download 0.383 a.2.7 tRNA-binding arm
View Download 0.356 a.4.1 Homeodomain-like
View Download 0.351 a.5.2 UBA-like
View Download 0.347 a.2.10 Epsilon subunit of F1F0-ATP synthase C-terminal domain
View Download 0.338 d.58.10 Acylphosphatase-like
View Download 0.338 a.46.2 Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain
View Download 0.338 a.74.1 Cyclin-like
View Download 0.334 a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.327 a.56.1 CO dehydrogenase ISP C-domain like
View Download 0.322 a.77.1 DEATH domain
View Download 0.319 a.8.1 Bacterial immunoglobulin/albumin-binding domains
View Download 0.309 a.57.1 Protein HNS-dependent expression A; HdeA
View Download 0.300 a.4.5 "Winged helix" DNA-binding domain
View Download 0.299 a.74.1 Cyclin-like
View Download 0.296 a.37.1 A DNA-binding domain in eukaryotic transcription factors
View Download 0.289 d.50.3 PI-Pfui intein middle domain
View Download 0.289 a.4.1 Homeodomain-like
View Download 0.280 a.74.1 Cyclin-like
View Download 0.276 a.2.7 tRNA-binding arm
View Download 0.275 a.44.1 Disulphide-bond formation facilitator (DSBA), insertion domain
View Download 0.275 a.4.5 "Winged helix" DNA-binding domain
View Download 0.274 a.4.13 Sigma3 and sigma4 domains of RNA polymerase sigma factors
View Download 0.274 a.65.1 Annexin
View Download 0.273 a.46.2 Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain
View Download 0.264 a.47.2 t-snare proteins
View Download 0.263 a.3.1 Cytochrome c
View Download 0.258 d.48.1 RecA protein, C-terminal domain
View Download 0.255 a.3.1 Cytochrome c
View Download 0.249 a.28.1 ACP-like
View Download 0.248 a.30.1 ROP protein
View Download 0.244 a.2.1 GreA transcript cleavage protein, N-terminal domain
View Download 0.243 a.7.3 Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain
View Download 0.242 a.4.5 "Winged helix" DNA-binding domain
View Download 0.241 a.4.1 Homeodomain-like
View Download 0.238 a.60.5 Barrier-to-autointegration factor, BAF
View Download 0.230 d.42.1 POZ domain
View Download 0.230 a.3.1 Cytochrome c
View Download 0.229 a.21.1 HMG-box
View Download 0.229 a.76.1 Iron-dependent represor protein, dimerization domain
View Download 0.228 g.63.1 Mollusk pheromone
View Download 0.225 a.4.5 "Winged helix" DNA-binding domain
View Download 0.225 a.65.1 Annexin
View Download 0.223 a.56.1 CO dehydrogenase ISP C-domain like
View Download 0.219 a.101.1 Uteroglobin-like
View Download 0.218 a.60.3 C-terminal domain of RNA polymerase alpha subunit
View Download 0.218 d.50.3 PI-Pfui intein middle domain
View Download 0.217 a.28.1 ACP-like
View Download 0.215 a.3.1 Cytochrome c
View Download 0.211 a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.207 a.7.7 BAG domain
View Download 0.204 a.6.1 Putative DNA-binding domain
View Download 0.202 a.118.8 TPR-like
View Download 0.201 a.4.10 N-terminal Zn binding domain of HIV integrase
View Download 0.201 a.4.1 Homeodomain-like

Predicted Domain #2
Region A:
Residues: [67-533]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PDELFEKCTH YYRSPVSDTW KLLSSKEAAD IYTPFHYYLS TISFQSKDNS TTLPSLDDVI  60
   61 YSVDHTRYLL SEEPKIPTEL VSENGTKWRL RNNSNFILDL HNIYRNMVKQ FSNKTSEFDQ 120
  121 FDLFIILAAY LTLFYTLCCL FNDMRKIGSK FWLSFSALSN SACALYLSLY TTHSLLKKPA 180
  181 SLLSLVIGLP FIVVIIGFKH KVRLAAFSLQ KFHRISIDKK ITVSNIIYEA MFQEGAYLIR 240
  241 DYLFYISSFI GCAIYARHLP GLVNFCILST FMLVFDLLLS ATFYSAILSM KLEINIIHRS 300
  301 TVIRQTLEED GVVPTTADII YKDETASEPH FLRSNVAIIL GKASVIGLLL LINLYVFTDK 360
  361 LNATILNTVY FDSTIYSLPN FINYKDIGNL SNQVIISVLP KQYYTPLKKY HQIEDSVLLI 420
  421 IDSVSNAIRD QFISKLLFFA FAVSISINVY LLNAAKIHTG YMNFQPQ

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [534-585]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SNKIDDLVVQ QKSATIEFSE TRSMPASSGL ETPVTAKDII ISEEIQNNEC VY

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.453 d.15.7 Immunoglobulin-binding domains
View Download 0.467 a.5.2 UBA-like
View Download 0.594 d.100.1 L9 N-domain-like
View Download 0.619 a.5.7 4-hydroxy-2-oxovalerate aldolase DmpG, communication domain
View Download 0.611 a.5.7 4-hydroxy-2-oxovalerate aldolase DmpG, communication domain
View Download 0.412 d.15.7 Immunoglobulin-binding domains
View Download 0.406 d.15.7 Immunoglobulin-binding domains
View Download 0.405 b.40.4 Nucleic acid-binding proteins
View Download 0.403 a.138.1 Multiheme cytochromes
View Download 0.334 d.58.17 Metal-binding domain
View Download 0.329 d.57.1 DNA damage-inducible protein DinI
View Download 0.273 b.40.4 Nucleic acid-binding proteins
View Download 0.263 b.1.18 E set domains
View Download 0.256 d.26.1 FKBP-like
View Download 0.227 d.58.17 Metal-binding domain
View Download 0.214 d.58.5 GlnB-like

Predicted Domain #4
Region A:
Residues: [586-685]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ALSSQDEPIR PLSNLVELME KEQLKNMNNT EVSNLVVNGK LPLYSLEKKL EDTTRAVLVR  60
   61 RKALSTLAES PILVSEKLPF RNYDYDRVFG ACCENVIGYM 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1590.0
Match: 1dq8A_
Description: NAD-binding domain of HMG-CoA reductase; Substrate-binding domain of HMG-CoA reductase
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [686-739]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PIPVGVIGPL IIDGTSYHIP MATTEGCLVA SAMRGCKAIN AGGGATTVLT KDGM

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [842-1045]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TDKKPAAINW IEGRGKSVVA EATIPGDVVK SVLKSDVSAL VELNISKNLV GSAMAGSVGG  60
   61 FNAHAANLVT ALFLALGQDP AQNVESSNCI TLMKEVDGDL RISVSMPSIE VGTIGGGTVL 120
  121 EPQGAMLDLL GVRGPHPTEP GANARQLARI IACAVLAGEL SLCSALAAGH LVQSHMTHNR 180
  181 KTNKANELPQ PSNKGPPCKT SALL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1590.0
Match: 1dq8A_
Description: NAD-binding domain of HMG-CoA reductase; Substrate-binding domain of HMG-CoA reductase
Matching Structure (courtesy of the PDB):

Predicted Domain #6
Region A:
Residues: [740-841]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TRGPVVRFPT LIRSGACKIW LDSEEGQNSI KKAFNSTSRF ARLQHIQTCL AGDLLFMRFR  60
   61 TTTGDAMGMN MISKGVEYSL KQMVEEYGWE DMEVVSVSGN YC

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1590.0
Match: 1dq8A_
Description: NAD-binding domain of HMG-CoA reductase; Substrate-binding domain of HMG-CoA reductase
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle