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View Structure Prediction Details

Protein: ATG23
Organism: Saccharomyces cerevisiae
Length: 453 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ATG23.

Description E-value Query
Range
Subject
Range
KRT84 - keratin 84
1.0E-94 [55..438] [144..508]
KRT84_MOUSE, K2H... - Keratin, type II cuticular Hb4 OS=Mus musculus GN=Krt84 PE=2 SV=1, (Q99M73) Keratin, type II cuticul...
3.0E-90 [55..450] [152..527]
K2M2_SHEEP - Keratin, type II microfibrillar, component 7C OS=Ovis aries PE=1 SV=1
8.0E-82 [55..435] [88..454]

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Predicted Domain #1
Region A:
Residues: [1-122]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MELNQVLEKK EQILQYLGTL VGLHEKALSD VNSASQVTSI RKDITICLND LCRINDLLVS  60
   61 HDGLLKREIG SLLRDKQELL ELNEREQLLW KERKSWHIKQ ETDAAPADYV IDKDAIITIS 120
  121 SH

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 22.09691
Match: 1i84S_
Description: Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [123-261]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HRTSLNKYIE SVGAENTILS NTDDSDAMIE EVQNAESSAD QMIRNYKLLQ LSHKQAKSEI  60
   61 IRLETLLRDF KKDNKFIEEE LKRQSGRIRS EMGNIDFHLS KIEESKHQLM KRIGFESPLT 120
  121 QEKSLSEKIF NLRLSSADE

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.939 0.760 autophagy a.47.2 t-snare proteins
View Download 0.732 0.006 protein targeting to vacuole a.7.1 Spectrin repeat
View Download 0.880 0.004 protein targeting to vacuole a.2.7 tRNA-binding arm
View Download 0.779 0.003 protein targeting to vacuole a.47.1 STAT
View Download 0.747 0.002 protein targeting to vacuole a.7.5 Tubulin chaperone cofactor A
View Download 0.718 N/A N/A a.7.4 Smac/diablo
View Download 0.711 N/A N/A a.29.5 alpha-ketoacid dehydrogenase kinase, N-terminal domain
View Download 0.666 N/A N/A a.24.9 alpha-catenin/vinculin
View Download 0.640 N/A N/A a.47.2 t-snare proteins
View Download 0.626 N/A N/A f.17.1 F1F0 ATP synthase subunit C
View Download 0.622 N/A N/A a.24.16 Nucleotidyltransferase substrate binding subunit/domain
View Download 0.604 N/A N/A a.2.6 Effector domain of the protein kinase pkn/prk1
View Download 0.601 N/A N/A a.26.1 4-helical cytokines
View Download 0.562 N/A N/A a.7.1 Spectrin repeat
View Download 0.541 N/A N/A a.2.5 Prefoldin
View Download 0.495 N/A N/A a.24.14 FAT domain of focal adhesion kinase
View Download 0.458 N/A N/A a.7.3 Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain
View Download 0.455 N/A N/A a.74.1 Cyclin-like
View Download 0.450 N/A N/A a.24.9 alpha-catenin/vinculin
View Download 0.439 N/A N/A a.25.1 Ferritin-like
View Download 0.438 N/A N/A a.2.8 Eukaryotic DNA topoisomerase I, dispensable insert domain
View Download 0.432 N/A N/A a.5.4 Elongation factor TFIIS domain 2
View Download 0.428 N/A N/A a.7.1 Spectrin repeat
View Download 0.419 N/A N/A a.7.7 BAG domain
View Download 0.393 N/A N/A a.37.1 A DNA-binding domain in eukaryotic transcription factors
View Download 0.376 N/A N/A a.24.9 alpha-catenin/vinculin
View Download 0.346 N/A N/A a.29.3 Acyl-CoA dehydrogenase C-terminal domain-like
View Download 0.342 N/A N/A a.72.1 Functional domain of the splicing factor Prp18
View Download 0.324 N/A N/A a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.309 N/A N/A a.7.1 Spectrin repeat
View Download 0.306 N/A N/A f.15.1 Small-conductance potassium channel
View Download 0.292 N/A N/A f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.291 N/A N/A f.21.2 Fumarate reductase respiratory complex transmembrane subunits
View Download 0.289 N/A N/A a.26.1 4-helical cytokines
View Download 0.283 N/A N/A a.29.3 Acyl-CoA dehydrogenase C-terminal domain-like
View Download 0.281 N/A N/A f.25.1 Cytochrome c oxidase subunit III-like
View Download 0.280 N/A N/A d.122.1 ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
View Download 0.279 N/A N/A a.118.1 ARM repeat
View Download 0.279 N/A N/A a.24.16 Nucleotidyltransferase substrate binding subunit/domain
View Download 0.277 N/A N/A a.24.3 Cytochromes
View Download 0.271 N/A N/A a.7.2 Enzyme IIa from lactose specific PTS, IIa-lac
View Download 0.269 N/A N/A a.62.1 Hepatitis B viral capsid (hbcag)
View Download 0.256 N/A N/A a.7.8 GAT domain
View Download 0.249 N/A N/A a.1.1 Globin-like
View Download 0.249 N/A N/A a.26.1 4-helical cytokines
View Download 0.248 N/A N/A a.7.5 Tubulin chaperone cofactor A
View Download 0.246 N/A N/A a.26.1 4-helical cytokines
View Download 0.246 N/A N/A a.24.4 Hemerythrin
View Download 0.242 N/A N/A a.4.5 "Winged helix" DNA-binding domain
View Download 0.240 N/A N/A a.1.1 Globin-like
View Download 0.239 N/A N/A a.22.1 Histone-fold
View Download 0.238 N/A N/A a.63.1 Apolipophorin-III
View Download 0.236 N/A N/A e.20.1 Heat shock protein 70kD (HSP70), C-terminal substrate-binding fragment
View Download 0.234 N/A N/A a.26.1 4-helical cytokines
View Download 0.229 N/A N/A a.2.11 Fe,Mn superoxide dismutase (SOD), N-terminal domain
View Download 0.224 N/A N/A a.168.1 GEF domain of SopE toxin
View Download 0.224 N/A N/A a.23.1 HSC20 (HSCB), C-terminal oligomerisation domain
View Download 0.222 N/A N/A f.17.2 Cytochrome c oxidase subunit II-like, transmembrane region
View Download 0.216 N/A N/A a.132.1 Heme oxygenase
View Download 0.215 N/A N/A c.43.1 CoA-dependent acyltransferases
View Download 0.212 N/A N/A d.108.1 Acyl-CoA N-acyltransferases (Nat)
View Download 0.211 N/A N/A a.24.1 Apolipoprotein
View Download 0.211 N/A N/A a.1.1 Globin-like
View Download 0.211 N/A N/A a.19.1 Fertilization protein

Predicted Domain #3
Region A:
Residues: [262-453]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DYNERQTINM KNFVHMKDLI ELKIEDLQEQ LMRNKNESST VLTQRELWLD CQKKVGDLES  60
   61 KLITKLRSSS NSKIPPNEMS EMINSTIQYL NNLLDSSDEK LTTTLISNER DVLSKACEEL 120
  121 HSESTTAQDG SSALPSKPID IHKSHKGSNA SSNLKQPSTP SFLVASKSPP KIGISESVVN 180
  181 ANKNDAISKK VE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 12.522879
Match: 1gk4A_
Description: Vimentin coil
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle