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View Structure Prediction Details

Protein: EST2
Organism: Saccharomyces cerevisiae
Length: 884 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for EST2.

Description E-value Query
Range
Subject
Range
gi|6323350|ref|N... - Est2p [Saccharomyces cerevisiae]
EST2 - Reverse transcriptase subunit of the telomerase holoenzyme, essential for telomerase core catalytic ...
0.0 [1..884] [1..884]
TERT - telomerase reverse transcriptase
0.0 [196..872] [342..1103]
gi|3023055 - gi|3023055|gb|AAC40212.1| telomerase catalytic subunit [synthetic construct]
0.0 [196..872] [342..1103]
TERT_MOUSE - Telomerase reverse transcriptase OS=Mus musculus GN=Tert PE=1 SV=1
0.0 [196..872] [347..1093]
gi|6572640 - gi|6572640|gb|AAF17334.1| telomerase catalytic subunit [Mesocricetus auratus]
0.0 [158..872] [310..1099]
gi|147907344, gi... - gi|147907344|ref|NP_001079102.1| telomerase reverse transcriptase [Xenopus laevis], gi|12003360|gb|A...
0.0 [147..872] [338..1162]
gi|6716756 - gi|6716756|gb|AAF26733.1|AF216872_1 telomerase reverse transcriptase 2 [Candida albicans]
0.0 [34..823] [29..821]
trt1 - telomerase reverse transcriptase 1 protein Trt1
TERT_SCHPO - Telomerase reverse transcriptase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=trt1 PE=1...
0.0 [57..819] [80..908]

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Predicted Domain #1
Region A:
Residues: [1-301]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKILFEFIQD KLDIDLQTNS TYKENLKCGH FNGLDEILTT CFALPNSRKI ALPCLPGDLS  60
   61 HKAVIDHCII YLLTGELYNN VLTFGYKIAR NEDVNNSLFC HSANVNVTLL KGAAWKMFHS 120
  121 LVGTYAFVDL LINYTVIQFN GQFFTQIVGN RCNEPHLPPK WVQRSSSSSA TAAQIKQLTE 180
  181 PVTNKQFLHK LNINSSSFFP YSKILPSSSS IKKLTDLREA IFPTNLVKIP QRLKVRINLT 240
  241 LQKLLKRHKR LNYVSILNSI CPPLEGTVLD LSHLSRQSPK ERVLKFIIVI LQKLLPQEMF 300
  301 G

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [302-584]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SKKNKGKIIK NLNLLLSLPL NGYLPFDSLL KKLRLKDFRW LFISDIWFTK HNFENLNQLA  60
   61 ICFISWLFRQ LIPKIIQTFF YCTEISSTVT IVYFRHDTWN KLITPFIVEY FKTYLVENNV 120
  121 CRNHNSYTLS NFNHSKMRII PKKSNNEFRI IAIPCRGADE EEFTIYKENH KNAIQPTQKI 180
  181 LEYLRNKRPT SFTKIYSPTQ IADRIKEFKQ RLLKKFNNVL PELYFMKFDV KSCYDSIPRM 240
  241 ECMRILKDAL KNENGFFVRS QYFFNTNTGV LKLFNVVNAS RVP

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [585-773]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KPYELYIDNV RTVHLSNQDV INVVEMEIFK TALWVEDKCY IREDGLFQGS SLSAPIVDLV  60
   61 YDDLLEFYSE FKASPSQDTL ILKLADDFLI ISTDQQQVIN IKKLAMGGFQ KYNAKANRDK 120
  121 ILAVSSQSDD DTVIQFCAMH IFVKELEVWK HSSTMNNFHI RSKSSKGIFR SLIALFNTRI 180
  181 SYKTIDTNL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 3.69897
Match: 1d0eA_
Description: MMLV reverse transcriptase
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [774-884]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NSTNTVLMQI DHVVKNISEC YKSAFKDLSI NVTQNMQFHS FLQRIIEMTV SGCPITKCDP  60
   61 LIEYEVRFTI LNGFLESLSS NTSKFKDNII LLRKEIQHLQ AYIYIYIHIV N

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.955 0.016 telomerase holoenzyme complex a.24.17 Group V grass pollen allergen

Predicted Domain #5
Region A:
Residues: [583-747]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VPKPYELYID NVRTVHLSNQ DVINVVEMEI FKTALWVEDK CYIREDGLFQ GSSLSAPIVD  60
   61 LVYDDLLEFY SEFKASPSQD TLILKLADDF LIISTDQQQV INIKKLAMGG FQKYNAKANR 120
  121 DKILAVSSQS DDDTVIQFCA MHIFVKELEV WKHSSTMNNF HIRSK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 5.0
Match: 1nndA
Description: Arginine 116 is Essential for Nucleic Acid Recognition by the Fingers Domain of Moloney Murine Leukemia Virus Reverse Transcriptase
Matching Structure (courtesy of the PDB):

Predicted Domain #6
Region A:
Residues: [748-884]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSKGIFRSLI ALFNTRISYK TIDTNLNSTN TVLMQIDHVV KNISECYKSA FKDLSINVTQ  60
   61 NMQFHSFLQR IIEMTVSGCP ITKCDPLIEY EVRFTILNGF LESLSSNTSK FKDNIILLRK 120
  121 EIQHLQAYIY IYIHIVN

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.955 N/A N/A a.24.17 Group V grass pollen allergen


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle