YRC Public Data Repository - Protein Structure Prediction

Protein:	YLR118C
Organism:	Saccharomyces cerevisiae
Length:	227 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YLR118C.

Description	E-value	Query Range	Subject Range
gi\|123996083, gi... - gi\|123996083\|gb\|ABM85643.1\| lysophospholipase I [synthetic construct], gi\|123981248\|gb\|ABM82453.1\| l... LYPLA1 - lysophospholipase I	2.0E-48	[4..226]	[11..227]
LYPA2_RAT - Acyl-protein thioesterase 2 OS=Rattus norvegicus GN=Lypla2 PE=1 SV=1	3.0E-48	[1..226]	[11..229]
LYPA2_MOUSE - Acyl-protein thioesterase 2 OS=Mus musculus GN=Lypla2 PE=1 SV=1	3.0E-48	[1..226]	[11..229]
gi\|3721988 - gi\|3721988\|gb\|AAC63431.1\| calcium-independent phospholipase A2 isoform 1 [Oryctolagus cuniculus]	4.0E-46	[7..226]	[3..216]
YLR118C - Acyl-protein thioesterase responsible for depalmitoylation of Gpa1p; green fluorescent protein (GFP)... gi\|207343062 - gi\|207343062\|gb\|EDZ70640.1\| YLR118Cp-like protein [Saccharomyces cerevisiae AWRI1631] gi\|190406151 - gi\|190406151\|gb\|EDV09418.1\| conserved hypothetical protein [Saccharomyces cerevisiae RM11-1a] APTH1_YEAST - Acyl-protein thioesterase 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=YLR118C PE=1... gi\|151941283 - gi\|151941283\|gb\|EDN59661.1\| acyl-protein thioesterase [Saccharomyces cerevisiae YJM789]	8.0E-42	[1..227]	[1..227]

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Predicted Domain #1

Region A:
Residues: [1-227]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNGLRVAAKI QPARQTIIFL HGLGDTGSGW GFLAQYLQQR DPAAFQHTNF VFPNAPELHV  60
   61 TANGGALMPA WFDILEWDPS FSKVDSDGFM NSLNSIEKTV KQEIDKGIKP EQIIIGGFSQ 120
  121 GAALALATSV TLPWKIGGIV ALSGFCSIPG ILKQHKNGIN VKTPIFHGHG DMDPVVPIGL 180
  181 GIKAKQFYQD SCEIQNYEFK VYKGMAHSTV PDELEDLASF IKKSLSS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	362.502279
Match:	1fj2A_
Description:	Acyl protein thioesterase 1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
hydrolase activity	2.24106351016868	bayes_pls_golite062009
catalytic activity	1.39629727416851	bayes_pls_golite062009
hydrolase activity, acting on ester bonds	1.09488027320166	bayes_pls_golite062009
lipase activity	0.849473630399459	bayes_pls_golite062009
carboxylesterase activity	0.424330502936163	bayes_pls_golite062009
palmitoyl-(protein) hydrolase activity	0.277033874372149	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: