YRC Public Data Repository - Protein Structure Prediction

Protein:	HRT3
Organism:	Saccharomyces cerevisiae
Length:	344 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HRT3.

Description	E-value	Query Range	Subject Range
HRT3_YEAST - F-box protein HRT3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HRT3 PE=1 SV=1 HRT3 - Putative SCF-ubiquitin ligase F-box protein, based on both genetic and physical interactions and seq...	0.0	[1..344]	[1..344]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	0.0	[7..340]	[185..539]
FBXO9 - F-box protein 9	0.0	[7..340]	[85..439]
gi\|125628673, gi... - gi\|18044861\|gb\|AAH20074.1\| F-box protein 9 [Mus musculus], gi\|125628673\|ref\|NP_076094.2\| f-box only ...	0.0	[7..340]	[74..428]
SKI32_ARATH - F-box protein 7 OS=Arabidopsis thaliana GN=SKIP32 PE=1 SV=1	4.0E-48	[87..252]	[46..194]

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Predicted Domain #1

Region A:
Residues: [1-73]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIVDYEKDPR AKEAIAIWEK GVLKEKDGSM SDAINFYRSA LKIHDNVESL YRKKILDEWM  60
   61 LHKKLSGLSM TTD

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.905	0.987	nuclear ubiquitin ligase complex	a.4.5	"Winged helix" DNA-binding domain
View	Download	0.905	0.987	nuclear ubiquitin ligase complex	a.4.5	"Winged helix" DNA-binding domain
View	Download	0.838	0.987	nuclear ubiquitin ligase complex	a.4.5	"Winged helix" DNA-binding domain
View	Download	0.838	0.987	nuclear ubiquitin ligase complex	a.4.5	"Winged helix" DNA-binding domain
View	Download	0.832	0.987	nuclear ubiquitin ligase complex	a.4.5	"Winged helix" DNA-binding domain
View	Download	0.832	0.987	nuclear ubiquitin ligase complex	a.4.5	"Winged helix" DNA-binding domain
View	Download	0.767	0.987	nuclear ubiquitin ligase complex	a.4.5	"Winged helix" DNA-binding domain
View	Download	0.752	0.987	nuclear ubiquitin ligase complex	a.4.5	"Winged helix" DNA-binding domain
View	Download	0.724	0.987	nuclear ubiquitin ligase complex	a.23.4	Mitochondrial import receptor subunit Tom20
View	Download	0.706	0.987	nuclear ubiquitin ligase complex	a.4.1	Homeodomain-like
View	Download	0.687	0.987	nuclear ubiquitin ligase complex	a.4.5	"Winged helix" DNA-binding domain
View	Download	0.681	0.987	nuclear ubiquitin ligase complex	a.28.2	Colicin E immunity proteins
View	Download	0.675	0.987	nuclear ubiquitin ligase complex	a.4.5	"Winged helix" DNA-binding domain
View	Download	0.674	0.987	nuclear ubiquitin ligase complex	a.39.1	EF-hand
View	Download	0.666	0.987	nuclear ubiquitin ligase complex	a.60.5	Barrier-to-autointegration factor, BAF
View	Download	0.638	0.987	nuclear ubiquitin ligase complex	a.159.2	FF domain
View	Download	0.629	0.987	nuclear ubiquitin ligase complex	a.163.1	Crustacean CHH/MIH/GIH neurohormone
View	Download	0.627	0.987	nuclear ubiquitin ligase complex	a.60.9	lambda integrase-like, N-terminal domain
View	Download	0.604	0.987	nuclear ubiquitin ligase complex	a.24.13	Domain of the SRP/SRP receptor G-proteins
View	Download	0.592	0.987	nuclear ubiquitin ligase complex	a.4.1	Homeodomain-like
View	Download	0.589	0.987	nuclear ubiquitin ligase complex	a.4.1	Homeodomain-like
View	Download	0.556	0.987	nuclear ubiquitin ligase complex	a.56.1	CO dehydrogenase ISP C-domain like
View	Download	0.553	0.987	nuclear ubiquitin ligase complex	d.54.1	Enolase N-terminal domain-like
View	Download	0.532	0.987	nuclear ubiquitin ligase complex	a.4.1	Homeodomain-like
View	Download	0.516	0.987	nuclear ubiquitin ligase complex	a.74.1	Cyclin-like
View	Download	0.504	0.987	nuclear ubiquitin ligase complex	a.4.1	Homeodomain-like
View	Download	0.503	0.987	nuclear ubiquitin ligase complex	a.4.1	Homeodomain-like
View	Download	0.491	0.987	nuclear ubiquitin ligase complex	a.39.1	EF-hand
View	Download	0.478	0.987	nuclear ubiquitin ligase complex	a.4.1	Homeodomain-like
View	Download	0.469	0.987	nuclear ubiquitin ligase complex	a.4.1	Homeodomain-like
View	Download	0.467	0.987	nuclear ubiquitin ligase complex	a.4.13	Sigma3 and sigma4 domains of RNA polymerase sigma factors
View	Download	0.461	0.987	nuclear ubiquitin ligase complex	a.44.1	Disulphide-bond formation facilitator (DSBA), insertion domain
View	Download	0.447	0.987	nuclear ubiquitin ligase complex	a.35.1	lambda repressor-like DNA-binding domains
View	Download	0.442	0.987	nuclear ubiquitin ligase complex	a.8.1	Bacterial immunoglobulin/albumin-binding domains
View	Download	0.439	0.987	nuclear ubiquitin ligase complex	a.64.1	Saposin
View	Download	0.438	0.987	nuclear ubiquitin ligase complex	a.3.1	Cytochrome c
View	Download	0.420	0.987	nuclear ubiquitin ligase complex	a.36.1	Signal peptide-binding domain
View	Download	0.411	0.987	nuclear ubiquitin ligase complex	a.76.1	Iron-dependent represor protein, dimerization domain
View	Download	0.410	0.987	nuclear ubiquitin ligase complex	a.39.1	EF-hand
View	Download	0.405	0.987	nuclear ubiquitin ligase complex	a.28.3	Retrovirus capsid protein C-terminal domain
View	Download	0.401	0.987	nuclear ubiquitin ligase complex	a.39.1	EF-hand
View	Download	0.397	0.987	nuclear ubiquitin ligase complex	d.8.1	Urease, gamma-subunit
View	Download	0.390	0.987	nuclear ubiquitin ligase complex	a.16.1	S15/NS1 RNA-binding domain
View	Download	0.384	0.987	nuclear ubiquitin ligase complex	a.4.1	Homeodomain-like
View	Download	0.381	0.987	nuclear ubiquitin ligase complex	a.85.1	Hemocyanin, N-terminal domain
View	Download	0.379	0.987	nuclear ubiquitin ligase complex	a.52.1	Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View	Download	0.379	0.987	nuclear ubiquitin ligase complex	a.159.1	Protein serine/threonine phosphatase 2C, C-terminal domain
View	Download	0.376	0.987	nuclear ubiquitin ligase complex	a.52.1	Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View	Download	0.376	0.987	nuclear ubiquitin ligase complex	a.24.13	Domain of the SRP/SRP receptor G-proteins
View	Download	0.375	0.987	nuclear ubiquitin ligase complex	a.60.9	lambda integrase-like, N-terminal domain
View	Download	0.364	0.987	nuclear ubiquitin ligase complex	a.64.1	Saposin
View	Download	0.358	0.987	nuclear ubiquitin ligase complex	a.24.17	Group V grass pollen allergen
View	Download	0.355	0.987	nuclear ubiquitin ligase complex	a.28.1	ACP-like
View	Download	0.350	0.987	nuclear ubiquitin ligase complex	a.4.1	Homeodomain-like
View	Download	0.342	0.987	nuclear ubiquitin ligase complex	a.28.1	ACP-like
View	Download	0.334	0.987	nuclear ubiquitin ligase complex	a.4.5	"Winged helix" DNA-binding domain
View	Download	0.329	0.987	nuclear ubiquitin ligase complex	a.4.6	C-terminal effector domain of the bipartite response regulators
View	Download	0.329	0.987	nuclear ubiquitin ligase complex	a.4.6	C-terminal effector domain of the bipartite response regulators
View	Download	0.324	0.987	nuclear ubiquitin ligase complex	a.74.1	Cyclin-like
View	Download	0.319	0.987	nuclear ubiquitin ligase complex	a.60.3	C-terminal domain of RNA polymerase alpha subunit
View	Download	0.307	0.987	nuclear ubiquitin ligase complex	a.39.2	Insect pheromon/odorant-binding proteins
View	Download	0.302	0.987	nuclear ubiquitin ligase complex	a.24.15	FAD-dependent thiol oxidase
View	Download	0.296	0.987	nuclear ubiquitin ligase complex	a.45.1	Glutathione S-transferase (GST), C-terminal domain
View	Download	0.295	0.987	nuclear ubiquitin ligase complex	d.39.1	Dynein light chain 8 (DLC8)
View	Download	0.290	0.987	nuclear ubiquitin ligase complex	a.161.1	beta-catenin-interacting protein ICAT
View	Download	0.283	0.987	nuclear ubiquitin ligase complex	a.4.9	Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3
View	Download	0.280	0.987	nuclear ubiquitin ligase complex	a.80.1	DNA polymerase III clamp loader subunits, C-terminal domain
View	Download	0.279	0.987	nuclear ubiquitin ligase complex	a.4.1	Homeodomain-like
View	Download	0.277	0.987	nuclear ubiquitin ligase complex	a.144.1	PABC (PABP) domain
View	Download	0.273	0.987	nuclear ubiquitin ligase complex	a.60.11	Hypothetical protein YjbJ
View	Download	0.272	0.987	nuclear ubiquitin ligase complex	a.65.1	Annexin
View	Download	0.270	0.987	nuclear ubiquitin ligase complex	a.4.2	Methylated DNA-protein cysteine methyltransferase, C-terminal domain
View	Download	0.266	0.987	nuclear ubiquitin ligase complex	a.4.11	RNA polymerase subunit RPB10
View	Download	0.265	0.987	nuclear ubiquitin ligase complex	a.28.1	ACP-like
View	Download	0.258	0.987	nuclear ubiquitin ligase complex	a.4.1	Homeodomain-like
View	Download	0.255	0.987	nuclear ubiquitin ligase complex	a.39.4	Hypothetical protein MTH865
View	Download	0.255	0.987	nuclear ubiquitin ligase complex	f.14.1	Voltage-gated potassium channels
View	Download	0.249	0.987	nuclear ubiquitin ligase complex	a.64.1	Saposin
View	Download	0.249	0.987	nuclear ubiquitin ligase complex	a.3.1	Cytochrome c
View	Download	0.248	0.987	nuclear ubiquitin ligase complex	a.153.1	Nuclear receptor coactivator interlocking domain
View	Download	0.244	0.987	nuclear ubiquitin ligase complex	a.2.7	tRNA-binding arm
View	Download	0.241	0.987	nuclear ubiquitin ligase complex	a.64.2	Bacteriocin AS-48
View	Download	0.238	0.987	nuclear ubiquitin ligase complex	a.101.1	Uteroglobin-like
View	Download	0.237	0.987	nuclear ubiquitin ligase complex	d.54.1	Enolase N-terminal domain-like
View	Download	0.234	0.987	nuclear ubiquitin ligase complex	a.52.1	Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View	Download	0.232	0.987	nuclear ubiquitin ligase complex	a.112.1	Description not found.
View	Download	0.231	0.987	nuclear ubiquitin ligase complex	d.203.1	DsrC, the gamma subunit of dissimilatory sulfite reductase
View	Download	0.227	0.987	nuclear ubiquitin ligase complex	a.40.1	Calponin-homology domain, CH-domain
View	Download	0.221	0.987	nuclear ubiquitin ligase complex	a.4.6	C-terminal effector domain of the bipartite response regulators
View	Download	0.219	0.987	nuclear ubiquitin ligase complex	a.4.13	Sigma3 and sigma4 domains of RNA polymerase sigma factors
View	Download	0.217	0.987	nuclear ubiquitin ligase complex	a.52.1	Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View	Download	0.215	0.987	nuclear ubiquitin ligase complex	a.24.4	Hemerythrin
View	Download	0.213	0.987	nuclear ubiquitin ligase complex	a.81.1	N-terminal domain of DnaB helicase
View	Download	0.208	0.987	nuclear ubiquitin ligase complex	a.77.1	DEATH domain
View	Download	0.207	0.987	nuclear ubiquitin ligase complex	a.126.1	Serum albumin-like
View	Download	0.207	0.987	nuclear ubiquitin ligase complex	d.68.1	Translation initiation factor IF3, C-terminal domain
View	Download	0.204	0.987	nuclear ubiquitin ligase complex	a.118.11	Cytochrome c oxidase subunit E
View	Download	0.202	0.987	nuclear ubiquitin ligase complex	a.28.3	Retrovirus capsid protein C-terminal domain
View	Download	0.201	0.987	nuclear ubiquitin ligase complex	a.77.1	DEATH domain

Predicted Domain #2

Region A:
Residues: [74-189]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 APDEQNETGK DDLSVEENAE LQPCWILEIL PDDILLRIIK KVILMSGESW VNLSMTCSTF  60
   61 SKLCFHDSVP FKTFAKYIYS KQIYDKMAMD LNGITDINTF EKEIWRGDDY RMLRER

[Run NCBI BLAST on this sequence.]

Detection Method:	Pfam
Confidence:	2.481486
Match:	PF00646
Description:	F-box domain

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.765	N/A	N/A	a.60.9	lambda integrase-like, N-terminal domain
View	Download	0.563	N/A	N/A	a.80.1	DNA polymerase III clamp loader subunits, C-terminal domain
View	Download	0.352	N/A	N/A	a.3.1	Cytochrome c
View	Download	0.349	N/A	N/A	d.150.1	4'-phosphopantetheinyl transferase
View	Download	0.320	N/A	N/A	a.101.1	Uteroglobin-like

Predicted Domain #3

Region A:
Residues: [190-344]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PYIKFEGVYI SVVNYVRYGS NAESSLSLLK PVHMITYYRY FRFYENGQCL RLLSTDEPSA  60
   61 VVKHFSKENK PRHSHMCYWS LGFDYDFGHL KITRSDEKYT FIEEFQIKNQ GNKRYQRLKW 120
  121 LSSIVVDKEG NASNCSLRNE KSFFFSRVKS FKDPG

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits