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View Structure Prediction Details

Protein: REX2
Organism: Saccharomyces cerevisiae
Length: 269 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for REX2.

Description E-value Query
Range
Subject
Range
REX2 - 3'-5' RNA exonuclease; involved in 3'-end processing of U4 and U5 snRNAs, 5S and 5.8S rRNAs, and RNa...
ORN_YEAST - Oligoribonuclease, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=REX2 PE...
3.0E-66 [1..269] [1..269]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
1.0E-47 [6..266] [378..610]
DPO3_BACSU - DNA polymerase III polC-type OS=Bacillus subtilis GN=polC PE=1 SV=2
gi|221318783 - gi|221318783|ref|ZP_03600077.1| DNA polymerase III PolC [Bacillus subtilis subsp. subtilis str. JH64...
gi|221313860 - gi|221313860|ref|ZP_03595665.1| DNA polymerase III PolC [Bacillus subtilis subsp. subtilis str. NCIB...
gi|221323055 - gi|221323055|ref|ZP_03604349.1| DNA polymerase III PolC [Bacillus subtilis subsp. subtilis str. SMY]
DPO3_BACSU - DNA polymerase III PolC-type OS=Bacillus subtilis (strain 168) GN=polC PE=1 SV=2
1.0E-47 [6..266] [378..610]
gi|90583510, gi|... - gi|90583510|ref|ZP_01239266.1| DNA polymerase III, epsilon subunit:DNA polymerase III, alpha subunit...
gi|90586568, gi|... - gi|90586568|ref|ZP_01242262.1| DNA polymerase III, epsilon subunit:DNA polymerase III, alpha subunit...
DPO3_STAAM - DNA polymerase III PolC-type OS=Staphylococcus aureus (strain Mu50 / ATCC 700699) GN=polC PE=3 SV=1
gi|255006051 - gi|255006051|ref|ZP_05144652.2| DNA polymerase III PolC [Staphylococcus aureus subsp. aureus Mu50-om...
gi|253315620 - gi|253315620|ref|ZP_04838833.1| DNA polymerase III PolC [Staphylococcus aureus subsp. aureus str. CF...
gi|25312569 - pir||C89900 DNA polymerase III, alpha chain PolC-type [imported] - Staphylococcus aureus (strain N31...
DPO3_STAAN - DNA polymerase III PolC-type OS=Staphylococcus aureus (strain N315) GN=polC PE=1 SV=1
DPO3_STAA1 - DNA polymerase III PolC-type OS=Staphylococcus aureus (strain Mu3 / ATCC 700698) GN=polC PE=3 SV=1
1.0E-47 [6..266] [379..610]
DPO3_STAAU - DNA polymerase III PolC-type OS=Staphylococcus aureus GN=polC PE=3 SV=1
1.0E-47 [6..266] [377..608]
DPO3_BACHD - DNA polymerase III polC-type OS=Bacillus halodurans GN=polC PE=3 SV=1
DPO3_BACHD - DNA polymerase III PolC-type OS=Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / J...
3.0E-47 [6..266] [376..606]
gi|143342 - gi|143342|gb|AAA22666.1| polymerase III
2.0E-46 [6..266] [378..610]

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Predicted Domain #1
Region A:
Residues: [1-269]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKWLLFPARI VARTRPNLFS LYRRSVSQYL RPRTIQNLQS MAQTPELKTK LFKPLVWIDC  60
   61 EMTGLDHVND RIIEICCIIT DGHLAPVKAA DGQGDSHYES VIHYGPEVMN KMNEWCIEHH 120
  121 GNSGLTAKVL ASEKTLAQVE DELLEYIQRY IPDKNVGVLA GNSVHMDRLF MVREFPKVID 180
  181 HLFYRIVDVS SIMEVARRHN PALQARNPKK EAAHTAYSDI KESIAQLQWY MDNYLKPPQE 240
  241 TESVESIGSE QPESPSSSTS SLKRQRTDF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 24.522879
Match: 1fxxA_
Description: Exonuclease I
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
ribonuclease activity 4.81599779544001 bayes_pls_golite062009
exoribonuclease activity 3.01417328311605 bayes_pls_golite062009
ribonuclease H activity 2.91966688044755 bayes_pls_golite062009
exoribonuclease activity, producing 5'-phosphomonoesters 2.89077854960958 bayes_pls_golite062009
hydrolase activity, acting on ester bonds 2.70794511869438 bayes_pls_golite062009
nuclease activity 2.65398446409354 bayes_pls_golite062009
endonuclease activity 2.63074055051349 bayes_pls_golite062009
endoribonuclease activity 2.59247838057313 bayes_pls_golite062009
hydrolase activity 2.41899414621161 bayes_pls_golite062009
transcription regulator activity 2.20855917457806 bayes_pls_golite062009
endoribonuclease activity, producing 5'-phosphomonoesters 1.74431545836806 bayes_pls_golite062009
nucleic acid binding 1.73824903971928 bayes_pls_golite062009
DNA binding 1.62101283948059 bayes_pls_golite062009
endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 1.59628511603826 bayes_pls_golite062009
exonuclease activity 1.4327316829508 bayes_pls_golite062009
3'-5'-exoribonuclease activity 1.42069917818896 bayes_pls_golite062009
binding 1.35497934205068 bayes_pls_golite062009
catalytic activity 1.25233849524628 bayes_pls_golite062009
1.18236432793831 bayes_pls_golite062009
transcription factor activity 0.971926865662649 bayes_pls_golite062009
3'-5' exonuclease activity 0.86862629020506 bayes_pls_golite062009
RNA binding 0.750194803368593 bayes_pls_golite062009
exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 0.389326716045122 bayes_pls_golite062009
transcription activator activity 0.104967281174106 bayes_pls_golite062009
protein binding 0.035326007863533 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle