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View Structure Prediction Details

Protein: ERG3
Organism: Saccharomyces cerevisiae
Length: 365 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ERG3.

Description E-value Query
Range
Subject
Range
ERG3 - C-5 sterol desaturase, catalyzes the introduction of a C-5(6) double bond into episterol, a precurso...
ERG3_YEAST - Delta(7)-sterol 5(6)-desaturase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ERG3 PE=...
0.0 [1..365] [1..365]
ERG3_CANGA - Delta(7)-sterol 5(6)-desaturase OS=Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 06...
ERG3_CANGA - C-5 sterol desaturase OS=Candida glabrata GN=ERG3 PE=3 SV=1
5.0E-96 [1..365] [1..364]
ERG3_CANAX - Delta(7)-sterol 5(6)-desaturase OS=Candida albicans GN=ERG3 PE=3 SV=1
gi|238879059 - gi|238879059|gb|EEQ42697.1| C-5 sterol desaturase [Candida albicans WO-1]
2.0E-86 [1..355] [1..383]
SPBC27B12.03c - lathosterol oxidase
ERG32_SCHPO - Delta(7)-sterol 5(6)-desaturase erg32 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=erg3...
2.0E-63 [1..365] [1..329]
erg3 - C-5 sterol desaturase Erg3
ERG31_SCHPO - Delta(7)-sterol 5(6)-desaturase erg31 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=erg3...
1.0E-61 [84..365] [23..300]
gi|74178504, gi|... - gi|74178504|dbj|BAE32506.1| unnamed protein product [Mus musculus], gi|18848246|gb|AAH24132.1| Stero...
3.0E-58 [58..330] [3..271]
SC5D_RAT - Lathosterol oxidase OS=Rattus norvegicus GN=Sc5d PE=1 SV=1
4.0E-57 [58..330] [3..271]

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Predicted Domain #1
Region A:
Residues: [1-84]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDLVLEVADH YVLDDLYAKV LPASLAANIP VKWQKLLGLN SGFSNSTILQ ETLNSKNAVK  60
   61 ECRRFYGQVP FLFDMSTTSF ASLL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.304 d.120.1 Cytochrome b5
View Download 0.396 d.58.4 Dimeric alpha+beta barrel
View Download 0.600 d.52.3 Prokaryotic type KH domain (KH-domain type II)
View Download 0.300 a.28.2 Colicin E immunity proteins
View Download 0.600 d.52.3 Prokaryotic type KH domain (KH-domain type II)
View Download 0.529 a.64.2 Bacteriocin AS-48
View Download 0.529 a.64.2 Bacteriocin AS-48
View Download 0.396 d.58.4 Dimeric alpha+beta barrel
View Download 0.304 d.120.1 Cytochrome b5
View Download 0.300 a.28.2 Colicin E immunity proteins
View Download 0.281 c.47.1 Thioredoxin-like
View Download 0.279 d.58.8 Viral DNA-binding domain
View Download 0.273 a.60.5 Barrier-to-autointegration factor, BAF
View Download 0.270 d.129.2 Phosphoglucomutase, C-terminal domain
View Download 0.219 a.35.1 lambda repressor-like DNA-binding domains
View Download 0.216 a.4.5 "Winged helix" DNA-binding domain
View Download 0.210 a.74.1 Cyclin-like
View Download 0.205 a.163.1 Crustacean CHH/MIH/GIH neurohormone

Predicted Domain #2
Region A:
Residues: [85-365]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PRSSILREFL SLWVIVTIFG LLLYLFTASL SYVFVFDKSI FNHPRYLKNQ MAMEIKLAVS  60
   61 AIPWMSMLTV PWFVMELNGH SKLYMKIDYE NHGVRKLIIE YFTFIFFTDC GVYLAHRWLH 120
  121 WPRVYRALHK PHHKWLVCTP FASHSFHPVD GFLQSISYHI YPLILPLHKV SYLILFTFVN 180
  181 FWTVMIHDGQ YLSNNPAVNG TACHTVHHLY FNYNYGQFTT LWDRLGGSYR RPDDSLFDPK 240
  241 LRDAKETWDA QVKEVEHFIK EVEGDDNDRI YENDPNTKKN N

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 81.958607
Match: PF01598
Description: Sterol desaturase

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle