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View Structure Prediction Details

Protein: NOC3
Organism: Saccharomyces cerevisiae
Length: 663 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for NOC3.

Description E-value Query
Range
Subject
Range
NOC3_YEAST - Nucleolar complex-associated protein 3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=N...
gi|207343223 - gi|207343223|gb|EDZ70751.1| YLR002Cp-like protein [Saccharomyces cerevisiae AWRI1631]
NOC3 - Protein that forms a nuclear complex with Noc2p that binds to 66S ribosomal precursors to mediate th...
gi|151941170 - gi|151941170|gb|EDN59548.1| nucleolar complex subunit [Saccharomyces cerevisiae YJM789]
0.0 [1..663] [1..663]
NOC3L_MOUSE - Nucleolar complex protein 3 homolog OS=Mus musculus GN=Noc3l PE=2 SV=1
0.0 [4..657] [68..713]
NOC3L_CRIGR - Nucleolar complex protein 3 homolog OS=Cricetulus griseus GN=NOC3L PE=2 SV=1
0.0 [4..657] [68..714]
noc3 - Noc2p-Noc3p complex subunit Noc3
NOC3_SCHPO - Nucleolar complex-associated protein 3 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=noc...
0.0 [39..655] [121..742]
CE29708 - status:Partially_confirmed UniProt:P91136 protein_id:AAB42369.3
0.0 [22..657] [88..706]
gi|10434534 - gi|10434534|dbj|BAB14291.1| unnamed protein product [Homo sapiens]
0.0 [286..657] [4..345]
gi|18086412 - gi|18086412|gb|AAL57663.1| At2g17250/T23A1.11 [Arabidopsis thaliana]
5.0E-93 [128..663] [4..516]

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Predicted Domain #1
Region A:
Residues: [1-111]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAKRNRSQFR IQERTAKKRK HEDSLLEGNV FQNAPEDMDE NTIYSAKGSS WDEEEQDYEM  60
   61 VPRKNRSDTS NLVEGLPIKV NGKVERKLHK AQEKPKDDDE EDEDSNDSSE D

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
RNA binding 3.36069436734718 bayes_pls_golite062009
binding 2.36800795249393 bayes_pls_golite062009
nucleic acid binding 1.67566088591721 bayes_pls_golite062009
structural molecule activity 1.49650156618775 bayes_pls_golite062009
protein binding 1.3800948965226 bayes_pls_golite062009
mRNA binding 1.35186555044783 bayes_pls_golite062009
transcription regulator activity 1.08645493064764 bayes_pls_golite062009
DNA binding 0.806448013051712 bayes_pls_golite062009
transcription factor activity 0.371244009721798 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [112-263]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DEGPNEEQEA EAKEDEPDTE EKILQLKEDI ADLVTKVMEE PEENTAALGR LCKMVESKNP  60
   61 NTCKFSMLAL VPVFKSIIPG YRIRPLTETE KKEKVSKEVS KLRNFEQALV YNYKNYVGRL 120
  121 QSLSKTPSNA APIQVSLGIL ATQAAKELIS TA

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 9.86
Match: 1b3uA
Description: Constant regulatory domain of protein phosphatase 2a, pr65alpha
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [264-329]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SHFNFRTDIF TLLLRRICKP RISTDPTSIQ IIQTFETLLN EDEEGSISFE ILRIFNKILK  60
   61 TRNFNI

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 9.86
Match: 1b3uA
Description: Constant regulatory domain of protein phosphatase 2a, pr65alpha
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [330-470]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EESVLNMLLS LDVLHDYDPN TKLKGNVSAP KLKKKDRVHL SKKQRKARKE MQQIEEEMRN  60
   61 AEQAVSAEER ERNQSEILKI VFTIYLNILK NNAKTLIGSV LEGLTKFGNM ANFDLLGDFL 120
  121 EVMKELISDT EFDNLSSAEV R

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 9.86
Match: 1b3uA
Description: Constant regulatory domain of protein phosphatase 2a, pr65alpha
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [471-663]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KALLCIVSAF SLISNTQYMK VNVDLSKFVD GLYALLPYIC LDADIELSYR SLRLADPLNN  60
   61 EIIKPSVNVS TKAELLLKAL DHVFFRSKSG TKERATAFTK RLYMCISHTP EKTSIAILKF 120
  121 IDKLMNRYPE ISGLYSSEDR IGNGHFIMEA DNPSRSNPEA ATLWDNALLE KHYCPVVTKG 180
  181 LRSLSSRSKE CSK

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 9.86
Match: 1b3uA
Description: Constant regulatory domain of protein phosphatase 2a, pr65alpha
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle