YRC Public Data Repository - Protein Structure Prediction

Protein:	MHT1
Organism:	Saccharomyces cerevisiae
Length:	324 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MHT1.

Description	E-value	Query Range	Subject Range
gi\|207343298 - gi\|207343298\|gb\|EDZ70799.1\| YLL062Cp-like protein [Saccharomyces cerevisiae AWRI1631] gi\|190405993 - gi\|190405993\|gb\|EDV09260.1\| S-Methylmethionine Homocysteine methylTransferase [Saccharomyces cerevis... MHT1 - S-methylmethionine-homocysteine methyltransferase, functions along with Sam4p in the conversion of S... MHT1_YEAST - Homocysteine S-methyltransferase 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MHT1 ...	0.0	[1..324]	[1..324]
METH_RAT - Methionine synthase OS=Rattus norvegicus GN=Mtr PE=1 SV=1	3.0E-93	[1..322]	[1..328]
MTR - 5-methyltetrahydrofolate-homocysteine methyltransferase	2.0E-91	[1..322]	[14..340]
METH_ALIFS - Methionine synthase OS=Aliivibrio fischeri GN=metH PE=3 SV=1	2.0E-91	[1..320]	[1..327]
gi\|121630369, gi... - gi\|75816808\|ref\|ZP_00747268.1\| COG1410: Methionine synthase I, cobalamin-binding domain [Vibrio chol... gi\|121548155, gi... - gi\|121587582\|ref\|ZP_01677347.1\| 5-methyltetrahydrofolate--homocysteine methyltransferase [Vibrio cho... gi\|124118339, gi... - gi\|153223242\|ref\|ZP_01953739.1\| 5-methyltetrahydrofolate--homocysteine methyltransferase [Vibrio cho... gi\|126520229, gi... - gi\|229508815\|ref\|ZP_04398307.1\| 5-methyltetrahydrofolate--homocysteine methyltransferase [Vibrio cho... METH_VIBCH - Methionine synthase OS=Vibrio cholerae GN=metH PE=3 SV=1 gi\|227080601, gi... - gi\|227080601\|ref\|YP_002809152.1\| 5-methyltetrahydrofolate--homocysteine methyltransferase [Vibrio ch... gi\|229344492, gi... - gi\|229519803\|ref\|ZP_04409246.1\| 5-methyltetrahydrofolate--homocysteine methyltransferase [Vibrio cho... gi\|229368983, gi... - gi\|229606328\|ref\|YP_002876976.1\| 5-methyltetrahydrofolate--homocysteine methyltransferase [Vibrio ch... gi\|254850622, gi... - gi\|75829069\|ref\|ZP_00758388.1\| COG1410: Methionine synthase I, cobalamin-binding domain [Vibrio chol... METH_VIBCH - Methionine synthase OS=Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) GN=metH... gi\|75828368, gi\|... - gi\|75828368\|ref\|ZP_00757803.1\| COG1410: Methionine synthase I, cobalamin-binding domain [Vibrio chol...	6.0E-91	[1..320]	[1..326]
gi\|15889436, gi\|... - gi\|15889436\|ref\|NP_355117.1\| hypothetical protein AGR_C_3907 [Agrobacterium tumefaciens str. C58], g... gi\|25285954 - pir\|\|E97618 methionine synthase (PA1843) [imported] - Agrobacterium tumefaciens (strain C58, Cereon)	2.0E-90	[7..323]	[22..343]
METH_PSEAE - Methionine synthase OS=Pseudomonas aeruginosa GN=metH PE=3 SV=1 METH_PSEAE - Methionine synthase OS=Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228) ... gi\|84321306, gi\|... - gi\|84321306\|ref\|ZP_00969664.1\| COG1410: Methionine synthase I, cobalamin-binding domain [Pseudomonas... gi\|254240237, gi... - gi\|84327880\|ref\|ZP_00975894.1\| COG1410: Methionine synthase I, cobalamin-binding domain [Pseudomonas...	2.0E-89	[3..323]	[8..335]

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Predicted Domain #1

Region A:
Residues: [1-324]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKRIPIKELI VEHPGKVLIL DGGQGTELEN RGININSPVW SAAPFTSESF WEPSSQERKV  60
   61 VEEMYRDFMI AGANILMTIT YQANFQSISE NTSIKTLAAY KRFLDKIVSF TREFIGEERY 120
  121 LIGSIGPWAA HVSCEYTGDY GPHPENIDYY GFFKPQLENF NQNRDIDLIG FETIPNFHEL 180
  181 KAILSWDEDI ISKPFYIGLS VDDNSLLRDG TTLEEISVHI KGLGNKINKN LLLMGVNCVS 240
  241 FNQSALILKM LHEHLPGMPL LVYPNSGEIY NPKEKTWHRP TNKLDDWETT VKKFVDNGAR 300
  301 IIGGCCRTSP KDIAEIASAV DKYS

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	7.94
Match:	1dhpA
Description:	Dihydrodipicolinate synthase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
S-methyltransferase activity	3.53817178180686	bayes_pls_golite062009
homocysteine S-methyltransferase activity	2.53321380120921	bayes_pls_golite062009
catalytic activity	1.41033217274476	bayes_pls_golite062009
transferase activity	0.499011632852061	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: