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View Structure Prediction Details

Protein: KNS1
Organism: Saccharomyces cerevisiae
Length: 737 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for KNS1.

Description E-value Query
Range
Subject
Range
KNS1 - Nonessential putative protein kinase of unknown cellular role; member of the LAMMER family of protei...
KNS1_YEAST - Dual specificity protein kinase KNS1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=KNS...
0.0 [1..737] [1..737]
ppk5 - serine /threonine protein kinase Ppk5
PPK5_SCHPO - Serine/threonine-protein kinase ppk5 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=ppk5 ...
0.0 [1..655] [145..833]
gi|238478996, gi... - pir||D96699 hypothetical protein F12B7.13 [imported] - Arabidopsis thaliana, gi|238478996|ref|NP_00...
0.0 [22..673] [108..737]
gi|3236117 - gi|3236117|emb|CAA11861.1| shaggy kinase 6 [Petunia x hybrida]
0.0 [178..678] [4..467]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [178..678] [4..468]
gi|13358932 - gi|13358932|dbj|BAB33079.1| hypothetical protein [Macaca fascicularis]
0.0 [170..639] [21..482]

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Predicted Domain #1
Region A:
Residues: [1-156]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSQNIQIGTR KRSRANMNNS TTTGPANNTS SNKTFLDNFE ETRTNKLLDE MFARQNSFLT  60
   61 DNLRNSLDLN QADNPLRPRQ HQHQLFLDNE NAIELDEEPR IINTTINNSN NHNSSRVDED 120
  121 ADDDIIFIKE QPIQFSSPLI LPSSSSINNN NNIVTS

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [157-213]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NNPGCGTAAT SNSTYITTPK KFKKQRTISL PQLPLSKLSY QSNYFNVPDQ TNAIVPR

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [214-395]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VTQTENELLH LTGSCAKTLE GNKAVNLTIA HSTSPFSNPP AQIASLPQSN LKKQIGSSLR  60
   61 KFTSNGSSES ASSNKSNFKT DKDGHYVYQE NDIFGSGGRF VVKDLLGQGT FGKVLKCIDN 120
  121 KYEPNYVAVK VIRAVDRYRE AAKTELRILQ TILNNDPQGQ FQCLLLRECF DYKNHICLVT 180
  181 DL

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [650-677]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 WNLPPEKNWS LINSKLAWKR QTHSSSSS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 305.457575
Match: 1bmkA_
Description: MAP kinase p38
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [396-649]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YGRSIYDFMC SNGIARFPGS HIQAIARQLI RSVCFLHDLG IIHTDLKPEN ILICDETHIA  60
   61 QKLPLKTVQS LSKRRREASK GKRKILKNPE IKIIDFGSAI FHYEYHPPVI STRHYRAPEI 120
  121 VLGLGWSFPC DIWSIACVLV ELVIGESLYP IHENLEHMAM MQRINGTPFP TDIIDKMFYK 180
  181 SKHKLGNSPS DLNSTVIKHF DRKTLSLQWP EKNKRGDTIT TEKSMKRVLQ SCDRLDIYIS 240
  241 KVLKQDYGDS LSIN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 305.457575
Match: 1bmkA_
Description: MAP kinase p38
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [678-737]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TTDELDKETF LFWYWFIDLL RKMFEFDPTK RITAKDALDH EWFNLGILDD GIATYNNTQG  60
   61 

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 9.63
Match: 1i09A
Description: Glycogen synthase kinase-3 beta (Gsk3b)
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle