YRC Public Data Repository - Protein Structure Prediction

Protein:	KAE1
Organism:	Saccharomyces cerevisiae
Length:	421 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for KAE1.

Description	E-value	Query Range	Subject Range
gi\|15603103, gi\|... - gi\|15603103\|ref\|NP_246175.1\| O-sialoglycoprotein endopeptidase [Pasteurella multocida subsp. multoci...	3.0E-91	[51..417]	[1..341]
GCP_HAEIN - Probable O-sialoglycoprotein endopeptidase OS=Haemophilus influenzae GN=gcp PE=3 SV=1 TSAD_HAEIN - tRNA N6-adenosine threonylcarbamoyltransferase OS=Haemophilus influenzae (strain ATCC 51907 / DSM 11...	3.0E-90	[51..417]	[1..341]
gi\|220947960, gi... - gi\|220957196\|gb\|ACL91141.1\| CG4933-PA [synthetic construct], gi\|220947960\|gb\|ACL86523.1\| CG4933-PA [... CG4933-PA - This gene is referred to in FlyBase by the symbol Dmel\CG4933 (CG4933, FBgn0036615). It is a protein...	5.0E-89	[54..421]	[5..346]
GCP_HAEDU - Probable O-sialoglycoprotein endopeptidase OS=Haemophilus ducreyi GN=gcp PE=3 SV=1 TSAD_HAEDU - tRNA N6-adenosine threonylcarbamoyltransferase OS=Haemophilus ducreyi (strain 35000HP / ATCC 700724)...	1.0E-88	[51..412]	[1..336]
TSAD_SALTY - tRNA N6-adenosine threonylcarbamoyltransferase OS=Salmonella typhimurium (strain LT2 / SGSC1412 / AT... TSAD_SALG2 - tRNA N6-adenosine threonylcarbamoyltransferase OS=Salmonella gallinarum (strain 287/91 / NCTC 13346)... gi\|200387093, gi... - gi\|200387093\|ref\|ZP_03213705.1\| O-sialoglycoprotein endopeptidase [Salmonella enterica subsp. enteri... TSAD_SALDC - tRNA N6-adenosine threonylcarbamoyltransferase OS=Salmonella dublin (strain CT_02021853) GN=tsaD PE=... gi\|197265256, gi... - gi\|197265256\|ref\|ZP_03165330.1\| O-sialoglycoprotein endopeptidase [Salmonella enterica subsp. enteri... lcl\|NC_016856.1_... - [gene=gcp] [protein=O-sialoglycoprotein endopeptidase] [protein_id=YP_005239384.1] [location=complem... TSAD_SALEP - tRNA N6-adenosine threonylcarbamoyltransferase OS=Salmonella enteritidis PT4 (strain P125109) GN=tsa... gi\|167990238, gi... - gi\|205331153\|gb\|EDZ17917.1\| O-sialoglycoprotein endopeptidase [Salmonella enterica subsp. enterica s... GCP_SALTY - Probable O-sialoglycoprotein endopeptidase OS=Salmonella typhimurium GN=gcp PE=3 SV=2 GCP_SALTY - Probable tRNA threonylcarbamoyladenosine biosynthesis protein Gcp OS=Salmonella typhimurium GN=gcp P... TSAD_SALA4 - tRNA N6-adenosine threonylcarbamoyltransferase OS=Salmonella agona (strain SL483) GN=tsaD PE=3 SV=1 TSAD_SALHS - tRNA N6-adenosine threonylcarbamoyltransferase OS=Salmonella heidelberg (strain SL476) GN=tsaD PE=3 ... gi\|205348610, gi... - gi\|205348610\|gb\|EDZ35241.1\| O-sialoglycoprotein endopeptidase [Salmonella enterica subsp. enterica s... gi\|205337810, gi... - gi\|205337810\|gb\|EDZ24574.1\| O-sialoglycoprotein endopeptidase [Salmonella enterica subsp. enterica s...	3.0E-88	[51..417]	[1..336]
gi\|213616355 - gi\|213616355\|ref\|ZP_03372181.1\| O-sialoglycoprotein endopeptidase [Salmonella enterica subsp. enteri... GCP_SALTI - Probable O-sialoglycoprotein endopeptidase OS=Salmonella typhi GN=gcp PE=3 SV=1 gi\|213161046 - gi\|213161046\|ref\|ZP_03346756.1\| O-sialoglycoprotein endopeptidase [Salmonella enterica subsp. enteri... gi\|214001818 - gi\|214001818\|ref\|ZP_03412553.1\| O-sialoglycoprotein endopeptidase [Salmonella enterica subsp. enteri... gi\|213646109 - gi\|213646109\|ref\|ZP_03376162.1\| O-sialoglycoprotein endopeptidase [Salmonella enterica subsp. enteri... gi\|16761982 - gi\|16761982\|ref\|NP_457599.1\| O-sialoglycoprotein endopeptidase [Salmonella enterica subsp. enterica ... TSAD_SALTI - tRNA N6-adenosine threonylcarbamoyltransferase OS=Salmonella typhi GN=tsaD PE=3 SV=1 gi\|29143469, gi\|... - gi\|29143469\|ref\|NP_806811.1\| O-sialoglycoprotein endopeptidase [Salmonella enterica subsp. enterica ...	2.0E-87	[51..417]	[1..336]
EG11171 - tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein; glycation binding protein / tRNA(... EG11171 - tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein; glycation binding protein / tRNA(... GCP_ECOLI - Probable O-sialoglycoprotein endopeptidase (EC 3.4.24.57) (Glycoprotease) - Escherichia coli TSAD_ECOBW - tRNA N6-adenosine threonylcarbamoyltransferase OS=Escherichia coli (strain K12 / MC4100 / BW2952) GN... gi\|251786341, gi... - gi\|251786341\|ref\|YP_003000645.1\| hypothetical protein B21_02884 [Escherichia coli BL21], gi\|24237861... TSAD_ECODH - tRNA N6-adenosine threonylcarbamoyltransferase OS=Escherichia coli (strain K12 / DH10B) GN=tsaD PE=3... gi\|253323144, gi... - gi\|254289761\|ref\|YP_003055509.1\| O-sialoglycoprotein endopeptidase [Escherichia coli BL21(DE3)], gi\|... TSAD_ECOLU - tRNA N6-adenosine threonylcarbamoyltransferase OS=Escherichia coli O17:K52:H18 (strain UMN026 / ExPE... gi\|226839857, gi... - gi\|254038233\|ref\|ZP_04872291.1\| peptidase [Escherichia sp. 1_1_43], gi\|226839857\|gb\|EEH71878.1\| pept... gi\|253974912, gi... - gi\|254163011\|ref\|YP_003046119.1\| O-sialoglycoprotein endopeptidase [Escherichia coli B str. REL606],... gi\|83587498 - gi\|83587498\|ref\|ZP_00926125.1\| COG0533: Metal-dependent proteases with possible chaperone activity [... TSAD_SHIDS - tRNA N6-adenosine threonylcarbamoyltransferase OS=Shigella dysenteriae serotype 1 (strain Sd197) GN=... gi\|89109834, gi\|... - gi\|89109834\|ref\|AP_003614.1\| predicted peptidase [Escherichia coli str. K-12 substr. W3110], gi\|8567...	2.0E-87	[51..417]	[1..336]
TSAD_YERP3 - tRNA N6-adenosine threonylcarbamoyltransferase OS=Yersinia pseudotuberculosis serotype O:1b (strain ... gi\|115346450, gi... - gi\|218927839\|ref\|YP_002345714.1\| putative DNA-binding/iron metalloprotein/AP endonuclease [Yersinia ... TSAD_YERPS - tRNA N6-adenosine threonylcarbamoyltransferase OS=Yersinia pseudotuberculosis serotype I (strain IP3... GCP_YERPS - Probable tRNA threonylcarbamoyladenosine biosynthesis protein Gcp OS=Yersinia pseudotuberculosis GN=... gi\|161484752 - gi\|161484752\|ref\|NP_670831.2\| O-sialoglycoprotein endopeptidase [Yersinia pestis KIM] gi\|165924992, gi... - gi\|165924992\|ref\|ZP_02220824.1\| O-sialoglycoprotein endopeptidase [Yersinia pestis biovar Orientalis... gi\|165939882, gi... - gi\|89101994\|ref\|ZP_01174667.1\| COG0533: Metal-dependent proteases with possible chaperone activity [... TSAD_YERPP - tRNA N6-adenosine threonylcarbamoyltransferase OS=Yersinia pestis (strain Pestoides F) GN=tsaD PE=3 ... TSAD_YERPG - tRNA N6-adenosine threonylcarbamoyltransferase OS=Yersinia pestis bv. Antiqua (strain Angola) GN=tsa... TSAD_YERPA - tRNA N6-adenosine threonylcarbamoyltransferase OS=Yersinia pestis bv. Antiqua (strain Antiqua) GN=ts... gi\|166206697, gi... - gi\|166211951\|ref\|ZP_02237986.1\| O-sialoglycoprotein endopeptidase [Yersinia pestis biovar Antiqua st... TSAD_YERPN - tRNA N6-adenosine threonylcarbamoyltransferase OS=Yersinia pestis bv. Antiqua (strain Nepal516) GN=t... gi\|166008978, gi... - gi\|166008978\|ref\|ZP_02229876.1\| O-sialoglycoprotein endopeptidase [Yersinia pestis biovar Antiqua st... gi\|229837325, gi... - gi\|229837325\|ref\|ZP_04457488.1\| predicted peptidase [Yersinia pestis Pestoides A], gi\|229705448\|gb\|E... gi\|229840537, gi... - gi\|229840537\|ref\|ZP_04460696.1\| predicted peptidase [Yersinia pestis biovar Orientalis str. PEXU2], ... gi\|229690182, gi... - gi\|229842915\|ref\|ZP_04463067.1\| predicted peptidase [Yersinia pestis biovar Orientalis str. India 19... gi\|150260322, gi... - gi\|150260322\|ref\|ZP_01917050.1\| putative glycoprotease [Yersinia pestis CA88-4125], gi\|149289730\|gb\|... gi\|166963127, gi... - gi\|167419133\|ref\|ZP_02310886.1\| O-sialoglycoprotein endopeptidase [Yersinia pestis biovar Orientalis... gi\|167398806, gi... - gi\|167398806\|ref\|ZP_02304330.1\| O-sialoglycoprotein endopeptidase [Yersinia pestis biovar Antiqua st... gi\|167470413 - gi\|167470413\|ref\|ZP_02335117.1\| O-sialoglycoprotein endopeptidase [Yersinia pestis FV-1] gi\|167425091, gi... - gi\|167425091\|ref\|ZP_02316844.1\| O-sialoglycoprotein endopeptidase [Yersinia pestis biovar Mediaevali... TSAD_YERPB - tRNA N6-adenosine threonylcarbamoyltransferase OS=Yersinia pseudotuberculosis serotype IB (strain PB... TSAD_YERPY - tRNA N6-adenosine threonylcarbamoyltransferase OS=Yersinia pseudotuberculosis serotype O:3 (strain Y... gi\|45442724, gi\|... - gi\|45442724\|ref\|NP_994263.1\| O-sialoglycoprotein endopeptidase [Yersinia pestis biovar Microtus str.... TSAD_YERPE - tRNA N6-adenosine threonylcarbamoyltransferase OS=Yersinia pestis GN=tsaD PE=3 SV=1	2.0E-87	[51..418]	[1..337]
TSAD_MANHA - tRNA N6-adenosine threonylcarbamoyltransferase OS=Mannheimia haemolytica GN=tsaD PE=1 SV=1	3.0E-87	[51..393]	[1..319]
gi\|13363420, gi\|... - gi\|15833201\|ref\|NP_311974.1\| putative DNA-binding/iron metalloprotein/AP endonuclease [Escherichia c... gi\|217327754, gi... - gi\|217327754\|ref\|ZP_03443837.1\| O-sialoglycoprotein endopeptidase [Escherichia coli O157:H7 str. TW1... TSAD_ECO57 - tRNA N6-adenosine threonylcarbamoyltransferase OS=Escherichia coli O157:H7 GN=tsaD PE=3 SV=1 gi\|209759260, gi... - pir\|\|B85967 probable O-sialoglycoprotein endopeptidase ygjD [imported] - Escherichia coli (strain O1... gi\|12517643, gi\|... - gi\|15803606\|ref\|NP_289639.1\| O-sialoglycoprotein endopeptidase [Escherichia coli O157:H7 EDL933], gi...	3.0E-87	[51..417]	[1..336]

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Predicted Domain #1

Region A:
Residues: [1-170]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMSSRVTIFT SCNDAYIYLL REGNSQAFPN AVGSKMVNLN TIPPKNGRDY YIALGLEGSA  60
   61 NKLGVGIVKH PLLPKHANSD LSYDCEAEML SNIRDTYVTP PGEGFLPRDT ARHHRNWCIR 120
  121 LIKQALAEAD IKSPTLDIDV ICFTKGPGMG APLHSVVIAA RTCSLLWDVP

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [381-421]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GVMIAQAGLL EYRMGGIVKD FSETVVTQKF RTDEVYAAWR D

[Run NCBI BLAST on this sequence.]

Detection Method:	Pcons
Confidence:	3.69
Match:	1huxA
Description:	Hydroxyglutaryl-CoA dehydratase component A
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [171-380]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LVGVNHCIGH IEMGREITKA QNPVVLYVSG GNTQVIAYSE KRYRIFGETL DIAIGNCLDR  60
   61 FARTLKIPNE PSPGYNIEQL AKKAPHKENL VELPYTVKGM DLSMSGILAS IDLLAKDLFK 120
  121 GNKKNKILFD KTTGEQKVTV EDLCYSLQEN LFAMLVEITE RAMAHVNSNQ VLIVGGVGCN 180
  181 VRLQEMMAQM CKDRANGQVH ATDNRFCIDN

[Run NCBI BLAST on this sequence.]

Detection Method:	Pcons
Confidence:	3.69
Match:	1huxA
Description:	Hydroxyglutaryl-CoA dehydratase component A
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits