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View Structure Prediction Details

Protein: SET3
Organism: Saccharomyces cerevisiae
Length: 751 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SET3.

Description E-value Query
Range
Subject
Range
SET3 - Defining member of the SET3 histone deacetylase complex which is a meiosis-specific repressor of spo...
SET3_YEAST - SET domain-containing protein 3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SET3 PE=...
0.0 [1..751] [1..751]
gi|19913361, gi|... - gi|19913361|ref|NP_579891.1| Wolf-Hirschhorn syndrome candidate 1 protein isoform 5 [Homo sapiens], ...
3.0E-65 [122..495] [53..435]
EZH2A_XENLA - Histone-lysine N-methyltransferase EZH2 OS=Xenopus laevis GN=ezh2-a PE=2 SV=1
3.0E-59 [27..464] [328..737]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
8.0E-59 [4..476] [3437..3865]

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Predicted Domain #1
Region A:
Residues: [1-110]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSVPNSKEQS LLDDASTLLL FSKGKKRAEE ASKIGSKTDT IEHDESHERE KKGAIEMAAA  60
   61 ALATASTVSL PLKKATEQSA AEAATSTAAK EETENQPQKQ PQWPVPDSYI 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.404 a.1.1 Globin-like
View Download 0.503 a.133.1 Phospholipase A2, PLA2
View Download 0.409 a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.559 a.46.1 Methionine synthase domain
View Download 0.559 a.46.1 Methionine synthase domain
View Download 0.503 a.133.1 Phospholipase A2, PLA2
View Download 0.503 a.133.1 Phospholipase A2, PLA2
View Download 0.503 a.133.1 Phospholipase A2, PLA2
View Download 0.409 a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.404 a.1.1 Globin-like
View Download 0.398 a.7.6 Ribosomal protein S20
View Download 0.371 a.7.6 Ribosomal protein S20
View Download 0.357 a.7.6 Ribosomal protein S20
View Download 0.336 a.29.2 Bromodomain
View Download 0.323 d.43.1 Elongation factor Ts (EF-Ts), dimerisation domain
View Download 0.320 a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.317 a.7.1 Spectrin repeat
View Download 0.301 a.23.1 HSC20 (HSCB), C-terminal oligomerisation domain
View Download 0.285 a.7.1 Spectrin repeat
View Download 0.285 f.1.4 Bcl-2 inhibitors of programmed cell death
View Download 0.278 a.63.1 Apolipophorin-III
View Download 0.273 a.100.1 6-phosphogluconate dehydrogenase C-terminal domain-like
View Download 0.265 a.46.1 Methionine synthase domain
View Download 0.264 a.46.1 Methionine synthase domain
View Download 0.261 a.46.1 Methionine synthase domain
View Download 0.257 b.40.4 Nucleic acid-binding proteins
View Download 0.254 a.7.6 Ribosomal protein S20
View Download 0.253 a.90.1 Transcription factor STAT-4 N-domain
View Download 0.252 a.48.1 N-terminal domain of cbl (N-cbl)
View Download 0.251 a.46.1 Methionine synthase domain
View Download 0.248 a.7.6 Ribosomal protein S20
View Download 0.247 a.24.4 Hemerythrin
View Download 0.245 a.24.17 Group V grass pollen allergen
View Download 0.237 a.24.1 Apolipoprotein
View Download 0.226 a.90.1 Transcription factor STAT-4 N-domain
View Download 0.223 a.24.3 Cytochromes
View Download 0.221 a.7.1 Spectrin repeat
View Download 0.218 a.7.6 Ribosomal protein S20
View Download 0.216 f.32.1 a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)
View Download 0.209 f.13.1 Family A G protein-coupled receptor-like
View Download 0.209 a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.205 a.133.1 Phospholipase A2, PLA2
View Download 0.203 a.7.1 Spectrin repeat
View Download 0.202 a.90.1 Transcription factor STAT-4 N-domain
View Download 0.202 a.26.1 4-helical cytokines

Predicted Domain #2
Region A:
Residues: [111-215]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VDPDAGIITC ICDLNDDDGF TIQCDHCNRW QHAICYGIKD IGMAPDDYLC NSCDPREVDI  60
   61 NLARKIQQER INVKTVEPSS SNNSASNKNN GRDRASSTTI SDVGD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 6.09691
Match: 1fp0A_
Description: Nuclear corepressor KAP-1 (TIF-1beta)
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [216-498]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SFSTDQDNTN HRDKRRKRNP SNNSIDSKNE SASVNSSDGL TSMPKKKEHF LSAKDAYGAI  60
   61 YLPLKDNVFK SDLIEPFLNK HMDDNWVIQY PHKTFKSVSI EVKPYADIAY SRTYPGFTKL 120
  121 GVYLKKDCIK GDFIQEILGE LDFYKNYLTD PRNHYRIWGT AKRRVIFHSH WPIYIDARLS 180
  181 GNSTRYLRRS CQPNVELVTI KLQDTDNRND KSSGRKSSRI KFVLRALRDI SEDEELYIKW 240
  241 QWDSKHPILK LIKGMTIDSL DDLERYGLIN SVETILSNGE CGC

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [499-751]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GNNSKDCYLL KVKRYAQSLY KSVKSRGKMN NRYKLNEILN QYNCKKRREP PILHRLEEKA  60
   61 QNTIERAPIL LNNFYRQKFL NRNNGPKIPQ KNTIDSTNNP DDIAKPFKFA LFAQHSSNIS 120
  121 VPKKNETSEK PLIITKSTDY DESHITNIEE LPIPVLLPIN KTSRQTANDV EESQSKNEHK 180
  181 LSRTPSLSNF NKELSKEAQH SQAKTKEIMT EASVNSRRES TPESIMHLSD FSSSQLHSKK 240
  241 KLSFADYRKK LLK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [580-751]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RNNGPKIPQK NTIDSTNNPD DIAKPFKFAL FAQHSSNISV PKKNETSEKP LIITKSTDYD  60
   61 ESHITNIEEL PIPVLLPINK TSRQTANDVE ESQSKNEHKL SRTPSLSNFN KELSKEAQHS 120
  121 QAKTKEIMTE ASVNSRREST PESIMHLSDF SSSQLHSKKK LSFADYRKKL LK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.


YRC Informatics Platform - Version 3.0
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