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View Structure Prediction Details

Protein: COS9
Organism: Saccharomyces cerevisiae
Length: 407 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for COS9.

Description E-value Query
Range
Subject
Range
COS4_YEAST - Protein COS4 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=COS4 PE=1 SV=1
COS4 - Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-enc...
577.0 [0..26] [404..1]

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Predicted Domain #1
Region A:
Residues: [1-89]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQIVRSCNSN NKPLIPSSNW HIAIRMRGDG VKDRSIDVLS LKHFESQKVV LPQDLFMDNF  60
   61 TWMFYEFFKC FTFRTWLLLL LLMWLPGFL

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.687 N/A N/A a.77.1 DEATH domain
View Download 0.687 N/A N/A a.77.1 DEATH domain
View Download 0.514 N/A N/A b.71.1 Glycosyl hydrolase domain
View Download 0.413 N/A N/A d.189.1 PX domain
View Download 0.315 N/A N/A a.60.1 SAM/Pointed domain
View Download 0.302 N/A N/A a.7.6 Ribosomal protein S20
View Download 0.301 N/A N/A d.26.1 FKBP-like
View Download 0.300 N/A N/A d.74.1 Pterin-4a-carbinolamine dehydratase (PCD)/dimerization cofactor of HNF1 (DCoH)
View Download 0.268 N/A N/A a.39.1 EF-hand
View Download 0.246 N/A N/A a.35.1 lambda repressor-like DNA-binding domains

Predicted Domain #2
Region A:
Residues: [90-199]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SQIKSINRIF PFKLCILVSC LVGIFLPNIY SFSHKSVLTN QLTQFSKEIV EHAPGTDTHD  60
   61 WETVAANLNS YFYENKAWNT EYFFFNAAEC QKAFRKVLLE PFSVKKDESS 

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 49.356547
Match: PF00674
Description: DUP family

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.904 N/A N/A a.2.17 Description not found.
View Download 0.848 N/A N/A a.29.16 Description not found.
View Download 0.845 N/A N/A a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.845 N/A N/A a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.822 N/A N/A a.47.2 t-snare proteins
View Download 0.822 N/A N/A a.47.2 t-snare proteins
View Download 0.816 N/A N/A f.39.1 Description not found.
View Download 0.780 N/A N/A f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.710 N/A N/A a.1.1 Globin-like

Predicted Domain #3
Region A:
Residues: [200-272]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KIKSFGDSVP YIEEALQVYS TEFDKKWKLF NTEKVWSPDN LEHVQLPKKT YRYKFTWVLK  60
   61 RIFNLWLFPA FIL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.737 d.327.1 Description not found.
View Download 0.734 f.17.1 F1F0 ATP synthase subunit C
View Download 0.734 a.4.6 C-terminal effector domain of the bipartite response regulators
View Download 0.721 d.57.1 DNA damage-inducible protein DinI
View Download 0.721 d.57.1 DNA damage-inducible protein DinI
View Download 0.719 d.58.3 Protease propeptides/inhibitors
View Download 0.713 d.58.18 Regulatory domain in the aminoacid metabolism
View Download 0.709 d.58.17 Metal-binding domain

Predicted Domain #4
Region A:
Residues: [273-407]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FLACIYVSWD KGHLFRILCC GGGFLLMVRV FQNMRPFSMH MEDKMQFLST IINEQESGAN  60
   61 GWDEIAKKMN RYLFEKKVWT SEEFFFDGID CEWFFNHFFY RLLSTKKPMF DRPLNVELWP 120
  121 YIKEAQLTRK QAPPV

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 59.481486
Match: PF00674
Description: DUP family

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.664 N/A N/A a.1.1 Globin-like
View Download 0.606 N/A N/A a.1.1 Globin-like
View Download 0.582 N/A N/A a.100.1 6-phosphogluconate dehydrogenase C-terminal domain-like
View Download 0.572 N/A N/A d.92.1 Metalloproteases ("zincins"), catalytic domain
View Download 0.461 N/A N/A a.7.4 Smac/diablo
View Download 0.461 N/A N/A a.7.4 Smac/diablo
View Download 0.451 N/A N/A a.1.1 Globin-like
View Download 0.388 N/A N/A a.1.1 Globin-like
View Download 0.375 N/A N/A a.1.1 Globin-like
View Download 0.375 N/A N/A a.25.2 Thermoplasma ferritin-like 4-helical bundle


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle