YRC Public Data Repository - Protein Structure Prediction

Protein:	PRS1
Organism:	Saccharomyces cerevisiae
Length:	427 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PRS1.

Description	E-value	Query Range	Subject Range
PRS1 - 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleot... KPR1_YEAST - Ribose-phosphate pyrophosphokinase 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PRS... gi\|207343664 - gi\|207343664\|gb\|EDZ71061.1\| YKL181Wp-like protein [Saccharomyces cerevisiae AWRI1631] gi\|190409663 - gi\|190409663\|gb\|EDV12928.1\| ribose-phosphate pyrophosphokinase [Saccharomyces cerevisiae RM11-1a] gi\|151941739 - gi\|151941739\|gb\|EDN60100.1\| ribose-phosphate pyrophosphokinase [Saccharomyces cerevisiae YJM789]	0.0	[1..427]	[1..427]
prs1 - ribose-phosphate pyrophosphokinase Prs1 KPR1_SCHPO - Ribose-phosphate pyrophosphokinase 1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPAC4...	0.0	[1..421]	[1..405]
PRPS1 - phosphoribosyl pyrophosphate synthetase 1 gi\|208967042, gi... - gi\|208967042\|dbj\|BAG73535.1\| phosphoribosyl pyrophosphate synthetase 1-like 1 [synthetic construct],... ENSCJAT00000043257 - null gi\|114689771, gi... - gi\|114689771\|ref\|XP_001144504.1\| PREDICTED: hypothetical protein isoform 2 [Pan troglodytes], gi\|114... PRPS1_PONAB - Ribose-phosphate pyrophosphokinase 1 OS=Pongo abelii GN=PRPS1 PE=2 SV=1 tr\|M3WGN3\|M3WGN3... - Phosphoribosyl pyrophosphate synthetase 1 OS=Felis catus GN=PRPS1 PE=3 SV=1 PRPS1_PONPY - Ribose-phosphate pyrophosphokinase I - Pongo pygmaeus (Orangutan) gi\|109131827 - gi\|109131827\|ref\|XP_001095604.1\| PREDICTED: similar to Ribose-phosphate pyrophosphokinase I (Phospho... PRPS1_MOUSE - Ribose-phosphate pyrophosphokinase 1 OS=Mus musculus GN=Prps1 PE=1 SV=4 PRPS1_BOVIN - Ribose-phosphate pyrophosphokinase 1 OS=Bos taurus GN=PRPS1 PE=2 SV=3 gi\|74008042 - gi\|74008042\|ref\|XP_850853.1\| PREDICTED: similar to Ribose-phosphate pyrophosphokinase I (Phosphoribo... PRPS1_RAT - Ribose-phosphate pyrophosphokinase 1 OS=Rattus norvegicus GN=Prps1 PE=1 SV=2	1.0E-98	[1..314]	[1..314]
PRPS1_MOUSE - Ribose-phosphate pyrophosphokinase 1 OS=Mus musculus GN=Prps1 PE=1 SV=3	1.0E-98	[1..314]	[1..314]
gi\|54641819, gi\|... - gi\|54641819\|gb\|EAL30569.1\| GA19849-PA [Drosophila pseudoobscura], gi\|125978070\|ref\|XP_001353068.1\| G... gi\|220948594, gi... - gi\|220958100\|gb\|ACL91593.1\| CG6767-PA [synthetic construct], gi\|220948594\|gb\|ACL86840.1\| CG6767-PA [... FBpp0311282, CG6... - This gene is referred to in FlyBase by the symbol Dmel\CG6767 (CG6767, FBgn0036030). It is a protein...	2.0E-97	[1..316]	[33..348]
tr\|G3I9Z3\|G3I9Z3... - Ribose-phosphate pyrophosphokinase 2 OS=Cricetulus griseus GN=I79_020407 PE=3 SV=1 PRPS2_RAT - Ribose-phosphate pyrophosphokinase 2 OS=Rattus norvegicus GN=Prps2 PE=1 SV=3	5.0E-97	[1..314]	[1..314]
gi\|3608149, gi\|1... - gi\|633140\|emb\|CAA58717.1\| phosphoribosyl diphosphate synthetase; ribose-phosphate pyrophosphokinase ...	2.0E-94	[3..327]	[41..345]

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Predicted Domain #1

Region A:
Residues: [1-145]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRKCKIFVGN SHPELGNMVC QRLGIEPAPC TLKKFANGET SVQIGVSVRD EDVYVIQSGS  60
   61 PSINDDIMEL LILVSACRGG SARKITAVIP QFPYSKQCKM KRHRGAITAR MLANLLVMAG 120
  121 ADHVVSMDLH ASQMQGFFTK PVDNL

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [293-314]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VDSEDEEEIP VLYREQLITL VG

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	484.0
Match:	1dkrA_
Description:	Phosphoribosylpyrophosphate synthetase
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [146-292]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YGGPSLAKWI RENVEDYEDA VVVSKNPGGT KRVTALADSL KINFAMIHTD RRRSKDLYSQ  60
   61 NKDLQQLKLR KQSMLRKNRP IIRQGDHPNE EENIILSNGI QTARIRNGHV IGDDEADDDE 120
  121 DAILESDSEL HSIDGLDSHG LGGTYDA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	484.0
Match:	1dkrA_
Description:	Phosphoribosylpyrophosphate synthetase
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [315-427]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NVRGRSAIIL DDMIDRPGSF ISAAEHLVQN CGAKKVYVVA THGIFTGDCL EELEKSDAID  60
   61 TIVVTNTYPI SGERIAGSKK LVTIDVSPIF AECIRRDHYG ESISVLFDSL AAL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	39.154902
Match:	1ao0A_
Description:	Glutamine PRPP amidotransferase, C-terminal domain; Glutamine PRPP amidotransferase, N-terminal domain
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits