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View Structure Prediction Details

Protein: KKQ8
Organism: Saccharomyces cerevisiae
Length: 734 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for KKQ8.

Description E-value Query
Range
Subject
Range
KKQ8_YEAST - Probable serine/threonine-protein kinase KKQ8 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288...
KKQ8 - Putative serine/threonine protein kinase with unknown cellular role
755.0 [0..11] [734..1]
gi|18175903 - gi|18175903|gb|AAL59948.1| putative calcium-dependent protein kinase [Arabidopsis thaliana]
444.0 [0..351] [733..6]
gi|16904226 - gi|16904226|gb|AAL30820.1|AF435452_1 calcium/calmodulin-dependent protein kinase CaMK3 [Nicotiana ta...
441.0 [0..289] [733..28]
gi|7434364, gi|1... - pir||T09940 calcium-dependent protein kinase (EC 2.7.1.-) CDPK - pumpkin, gi|1899175|gb|AAB49984.1| ...
437.0 [0..309] [733..8]
gi|5916094, gi|1... - gi|5916094|gb|AAD55890.1|AF134054_1 checkpoint kinase Chk2 [Rattus norvegicus], gi|16758490|ref|NP_4...
437.0 [0..194] [725..3]

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Predicted Domain #1
Region A:
Residues: [1-223]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMDSKTLTAS MVMQEEKKRQ QPVTRRVRSF SESFKNLFRP PRSRDSSPIN VTRIPYRSSS  60
   61 TSPKRSSEPP RRSTVSAQIL DPKNSPIRQR SYTLKCCTPG LSHPFRQTGS GASNSPTRHR 120
  121 SISGEEQEIV NSLPEYKRSA SHTFHGIRRP RSRSSSVSSC DSSNGTTSSS DSQWAMDSLL 180
  181 DDSDNDLTPY RGSNKDILKS KDRAPYNYID DYNKKALRRA TSY

[Run NCBI BLAST on this sequence.]

Detection Method: ab initio
Confidence: 8.91
Match:
Description: No description for 1ldvA was found.

Predicted Domain #2
Region A:
Residues: [224-369]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PNPLPSKQFY NERLYTRRSH PDEESLESLP RFAGADVQCI IEQNGFKVYE DGSHEHNIKL  60
   61 SGVIAKLEKG NSLPAHRQGS LSRPRLGITL SGLFKHHKNE CDIENALSLL PNVEKSQTNH 120
  121 EKRTGQSPND SNRSSPTQGR EDYLKI

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.694 a.118.8 TPR-like
View Download 0.595 a.24.10 Histidine-containing phosphotransfer domain, HPT domain
View Download 0.586 a.29.2 Bromodomain
View Download 0.586 a.29.2 Bromodomain
View Download 0.564 a.25.1 Ferritin-like
View Download 0.469 d.110.2 GAF domain-like
View Download 0.445 a.91.1 Regulator of G-protein signalling, RGS
View Download 0.398 f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore

Predicted Domain #3
Region A:
Residues: [370-528]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VNPDASLGSD ELKLINSLSS RIHKSLQNYL QEKNLKPAEC IGEQAPTFQD NYGHPVGLVG  60
   61 AGAYGEVKLC ARLRNEKDSP PFETYHDSKY IYYAVKELKP KPDSDLEKFC TKITSEFIIG 120
  121 HSLSHYHKNG KKPAPNILNV FDILEDSSSF IEVMEFCPA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 260.035458
Match: 1a06A
Description: CALMODULIN-DEPENDENT PROTEIN KINASE FROM RAT
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [529-734]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GDLYGMLVGK SKLKGRLHPL EADCFMKQLL HGVKFMHDHG IAHCDLKPEN ILFYPHGLLK  60
   61 ICDFGTSSVF QTAWERRVHA QKGIIGSEPY VAPEEFVDGE YYDPRLIDCW SCGVVYITMI 120
  121 LGHYLWKVAS REKDMSYDEF YKEMQRKNQF RVFEELKHVN SELATNRKIA LYRIFQWEPR 180
  181 KRISVGKLLD MQWMKSTNCC LIYDST

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 260.035458
Match: 1a06A
Description: CALMODULIN-DEPENDENT PROTEIN KINASE FROM RAT
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle