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View Structure Prediction Details

Protein: APE2
Organism: Saccharomyces cerevisiae
Length: 935 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for APE2.

Description E-value Query
Range
Subject
Range
APE2 - Aminopeptidase yscII; may have a role in obtaining leucine from dipeptide substrates; sequence coord...
0.0 [1..935] [1..935]
gi|7673021, gi|1... - gi|7673021|gb|AAF66704.1| aminopeptidase A [Rattus norvegicus], gi|11560059|ref|NP_071587.1| glutamy...
0.0 [16..934] [1..929]
gi|44980043, gi|... - gi|45184697|ref|NP_982415.1| AAL127Wp [Ashbya gossypii ATCC 10895], gi|44980043|gb|AAS50239.1| AAL12...
gi|44980043 - gi|44980043|gb|AAS50239.1| AAL127Wp [Ashbya gossypii ATCC 10895]
0.0 [102..934] [17..847]
AMPE_MOUSE - Glutamyl aminopeptidase OS=Mus musculus GN=Enpep PE=1 SV=1
0.0 [16..934] [1..929]
gi|32422353, gi|... - gi|32422353|ref|XP_331620.1| hypothetical protein [Neurospora crassa], gi|28920573|gb|EAA29936.1| am...
gi|85091989 - gi|85091989|ref|XP_959172.1| aminopeptidase 2 [Neurospora crassa OR74A]
0.0 [102..934] [22..859]
gi|40745602, gi|... - gi|67522362|ref|XP_659242.1| hypothetical protein AN1638.2 [Aspergillus nidulans FGSC A4], ref|XP_40...
0.0 [83..934] [2..859]
ANPEP - alanyl (membrane) aminopeptidase
0.0 [31..934] [8..950]

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Predicted Domain #1
Region A:
Residues: [1-89]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPIVRWLLLK SAVRGSSLIG KAHPCLRSIA AHPRYLSNVY SPPAGVSRSL RINVMWKQSK  60
   61 LTPPRFVKIM NRRPLFTETS HACAKCQKT

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [90-590]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SQLLNKTPNR EILPDNVVPL HYDLTVEPDF KTFKFEGSVK IELKINNPAI DTVTLNTVDT  60
   61 DIHSAKIGDV TSSEIISEEE QQVTTFAFPK GTMSSFKGNA FLDIKFTGIL NDNMAGFYRA 120
  121 KYEDKLTGET KYMATTQMEP TDARRAFPCF DEPNLKASFA ITLVSDPSLT HLSNMDVKNE 180
  181 YVKDGKKVTL FNTTPKMSTY LVAFIVAELK YVESKNFRIP VRVYATPGNE KHGQFAADLT 240
  241 AKTLAFFEKT FGIQYPLPKM DNVAVHEFSA GAMENWGLVT YRVVDLLLDK DNSTLDRIQR 300
  301 VAEVVQHELA HQWFGNLVTM DWWEGLWLNE GFATWMSWYS CNEFQPEWKV WEQYVTDTLQ 360
  361 HALSLDSLRS SHPIEVPVKK ADEINQIFDA ISYSKGASLL RMISKWLGEE TFIKGVSQYL 420
  421 NKFKYGNAKT EDLWDALADA SGKDVRSVMN IWTKKVGFPV ISVSEDGNGK ITFRQNRYLS 480
  481 TADVKPDEDK TIYPVFLALK T

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 84.69897
Match: 1gw6A_
Description: Leukotriene A4 hydrolase C-terminal domain; Leukotriene A4 hydrolase N-terminal domain; Leukotriene A4 hydrolase catalytic domain
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [591-808]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KNGVDSSVVL SERSKTIELE DPTFFKVNSE QSGIYITSYT DERWAKLGQQ ADLLSVEDRV  60
   61 GLVADVKTLS ASGYTSTTNF LNLVSKWNNE KSFVVWDQII NSISSMKSTW LFEPKETQDA 120
  121 LDNFTKQLIS GMTHHLGWEF KSSDSFSTQR LKVTMFGAAC AARDADVEKA ALKMFTDYCS 180
  181 GNKEAIPALI KPIVFNTVAR VGGAENYEKV YKIYLDPI

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [809-935]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SNDEKLAALR SLGRFKEPKL LERTLGYLFD GTVLNQDIYI PMQGMRAHQE GVEALWNWVK  60
   61 KNWDELVKRL PPGLSMLGSV VTLGTSGFTS MQKIDEIKKF FATKSTKGFD QSLAQSLDTI 120
  121 TSKAQWG

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle