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View Structure Prediction Details

Protein: GFA1
Organism: Saccharomyces cerevisiae
Length: 717 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for GFA1.

Description E-value Query
Range
Subject
Range
gi|190409730 - gi|190409730|gb|EDV12995.1| glucoseamine-6-phosphate synthase [Saccharomyces cerevisiae RM11-1a]
gi|151941699 - gi|151941699|gb|EDN60061.1| glucosamine-6-phosphate synthase [Saccharomyces cerevisiae YJM789]
GFA1 - Glutamine-fructose-6-phosphate amidotransferase, catalyzes the formation of glucosamine-6-P and glut...
GFA1_YEAST - Glutamine--fructose-6-phosphate aminotransferase [isomerizing] OS=Saccharomyces cerevisiae (strain A...
gi|207343559 - gi|207343559|gb|EDZ70990.1| YKL104Cp-like protein [Saccharomyces cerevisiae AWRI1631]
0.0 [1..717] [1..717]
GFPT1_MOUSE - Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 OS=Mus musculus GN=Gfpt1 PE=1 SV=3
0.0 [1..717] [1..697]
gi|4503981, gi|3... - gi|4503981|ref|NP_002047.1| glucosamine-fructose-6-phosphate aminotransferase [Homo sapiens], pir||A...
0.0 [1..717] [1..681]
Gfat2-PA - The gene Glutamine:fructose-6-phosphate aminotransferase 2 is referred to in FlyBase by the symbol D...
gi|220945236, gi... - gi|220954962|gb|ACL90024.1| Gfat2-PA [synthetic construct], gi|220945236|gb|ACL85161.1| Gfat2-PA [sy...
0.0 [1..717] [1..683]

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Predicted Domain #1
Region A:
Residues: [1-302]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MCGIFGYCNY LVERSRGEII DTLVDGLQRL EYRGYDSTGI AIDGDEADST FIYKQIGKVS  60
   61 ALKEEITKQN PNRDVTFVSH CGIAHTRWAT HGRPEQVNCH PQRSDPEDQF VVVHNGIITN 120
  121 FRELKTLLIN KGYKFESDTD TECIAKLYLH LYNTNLQNGH DLDFHELTKL VLLELEGSYG 180
  181 LLCKSCHYPN EVIATRKGSP LLIGVKSEKK LKVDFVDVEF PEENAGQPEI PLKSNNKSFG 240
  241 LGPKKAREFE AGSQNANLLP IAANEFNLRH SQSRAFLSED GSPTPVEFFV SSDAASVVKH 300
  301 TK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 966.9897
Match: 1jxaA_
Description: "Isomerase domain" of glucosamine 6-phosphate synthase (GLMS); Glucosamine 6-phosphate synthase, N-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
peptidase activity 1.34295853726897 bayes_pls_golite062009
catalytic activity 1.19663085909195 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 1.16226272745141 bayes_pls_golite062009
nucleic acid binding 0.798789250029517 bayes_pls_golite062009
endopeptidase activity 0.759765292911898 bayes_pls_golite062009
binding 0.541510243044181 bayes_pls_golite062009
transferase activity 0.526806728662348 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [303-548]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KVLFLEDDDL AHIYDGELHI HRSRREVGAS MTRSIQTLEM ELAQIMKGPY DHFMQKEIYE  60
   61 QPESTFNTMR GRIDYENNKV ILGGLKAWLP VVRRARRLIM IACGTSYHSC LATRAIFEEL 120
  121 SDIPVSVELA SDFLDRKCPV FRDDVCVFVS QSGETADTML ALNYCLERGA LTVGIVNSVG 180
  181 SSISRVTHCG VHINAGPEIG VASTKAYTSQ YIALVMFALS LSDDRVSKID RRIEIIQGLK 240
  241 LIPGQI

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [704-717]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VDFPRNLAKS VTVE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 966.9897
Match: 1jxaA_
Description: "Isomerase domain" of glucosamine 6-phosphate synthase (GLMS); Glucosamine 6-phosphate synthase, N-terminal domain
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [549-703]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KQVLKLEPRI KKLCATELKD QKSLLLLGRG YQFAAALEGA LKIKEISYMH SEGVLAGELK  60
   61 HGVLALVDEN LPIIAFGTRD SLFPKVVSSI EQVTARKGHP IIICNENDEV WAQKSKSIDL 120
  121 QTLEVPQTVD CLQGLINIIP LQLMSYWLAV NKGID

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 966.9897
Match: 1jxaA_
Description: "Isomerase domain" of glucosamine 6-phosphate synthase (GLMS); Glucosamine 6-phosphate synthase, N-terminal domain
Matching Structure (courtesy of the PDB):

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