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View Structure Prediction Details

Protein: CUE2
Organism: Saccharomyces cerevisiae
Length: 443 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CUE2.

Description E-value Query
Range
Subject
Range
CUE2 - Protein of unknown function; has two CUE domains that bind ubiquitin, which may facilitate intramole...
CUE2_YEAST - Ubiquitin-binding protein CUE2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CUE2 PE=1...
0.0 [1..443] [1..443]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
2.0E-35 [344..439] [85..167]
SPCC1235.03 - SMR and CUE domain protein
YCY3_SCHPO - Smr domain-containing protein C1235.03 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPC...
3.0E-33 [344..439] [306..388]
gi|7243207 - gi|7243207|dbj|BAA92651.1| KIAA1413 protein [Homo sapiens]
0.001 [347..430] [1320..1388]

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Predicted Domain #1
Region A:
Residues: [1-52]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSMDNNDDHE SKLSILMDMF PAISKSKLQV HLLENNNDLD LTIGLLLKEN DD

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 11.236572
Match: PF02845
Description: CUE domain

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.376 N/A N/A a.5.2 UBA-like
View Download 0.354 N/A N/A d.71.1 Cell division protein MinE topological specificity domain
View Download 0.328 N/A N/A a.5.7 4-hydroxy-2-oxovalerate aldolase DmpG, communication domain
View Download 0.301 N/A N/A a.5.2 UBA-like
View Download 0.294 N/A N/A a.8.1 Bacterial immunoglobulin/albumin-binding domains

Predicted Domain #2
Region A:
Residues: [53-103]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KSTVDNELHQ LYDMFPQLDC SVIKDQFVIN EKSVESTISD LLNYETLQKL K

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 11.585027
Match: PF02845
Description: CUE domain

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [104-331]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DNQANSPDSV KRNEKKNNWE STNDHIESII KFTDAPKNIA QEYLAENGFD TVKAIIKIIL  60
   61 DYYDKRDFKK DVDTFKVKRS PNTTVRGGRV QSSTGLAHVL KKGKESANVA QESLKRPRSY 120
  121 KHSLDSPQMV ELNELVADNR DLKAINHEFL QKCLQFYDGD VVKVLNISSL LIEDDKNITK 180
  181 TWNFDEGFTL TSRDNCKQHL PKFSTPQISR RNEVGNTYKL PLHDKETP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [332-443]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EGAVPVINNL FQTYRLDFHG FLPSEAVSTL KLALNKWWSK EVAERELNSH NINSYGSKVQ  60
   61 FVSPLIVVTG RGIHSIGGIS KVRLQVKSFL EKNHYIFWEE SSYFRIEGKK KK

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.575 0.172 protein binding a.25.1 Ferritin-like
View Download 0.550 0.081 protein binding d.110.4 SNARE-like
View Download 0.578 0.000 protein binding a.24.4 Hemerythrin
View Download 0.726 0.000 protein binding a.24.17 Group V grass pollen allergen
View Download 0.519 N/A N/A c.58.1 Aminoacid dehydrogenase-like, N-terminal domain
View Download 0.518 N/A N/A d.68.4 YhbY-like
View Download 0.517 N/A N/A a.24.17 Group V grass pollen allergen
View Download 0.516 N/A N/A a.71.2 Helical domain of Sec23/24
View Download 0.514 N/A N/A a.24.2 Aspartate receptor, ligand-binding domain
View Download 0.512 N/A N/A d.58.34 Formiminotransferase domain of formiminotransferase-cyclodeaminase.
View Download 0.470 N/A N/A c.24.1 Methylglyoxal synthase-like
View Download 0.459 N/A N/A c.30.1 PreATP-grasp domain
View Download 0.448 N/A N/A a.1.1 Globin-like
View Download 0.447 N/A N/A d.58.26 GHMP Kinase, C-terminal domain
View Download 0.438 N/A N/A a.118.11 Cytochrome c oxidase subunit E
View Download 0.431 N/A N/A d.198.2 Arp2/3 complex subunits
View Download 0.428 N/A N/A a.1.1 Globin-like
View Download 0.423 N/A N/A d.56.1 GroEL-intermediate domain like
View Download 0.419 N/A N/A f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.417 N/A N/A f.32.1 a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)
View Download 0.416 N/A N/A d.58.13 Anticodon-binding domain of PheRS
View Download 0.413 N/A N/A a.25.1 Ferritin-like
View Download 0.391 N/A N/A d.58.44 Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains
View Download 0.390 N/A N/A a.142.1 PTS-regulatory domain, PRD
View Download 0.382 N/A N/A a.71.2 Helical domain of Sec23/24
View Download 0.372 N/A N/A a.4.5 "Winged helix" DNA-binding domain
View Download 0.362 N/A N/A a.26.1 4-helical cytokines
View Download 0.358 N/A N/A a.11.2 Second domain of FERM
View Download 0.354 N/A N/A c.84.1 Phosphoglucomutase, first 3 domains
View Download 0.346 N/A N/A a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.345 N/A N/A a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.342 N/A N/A a.24.7 FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)
View Download 0.336 N/A N/A c.13.2 Anti-sigma factor antagonist SpoIIaa
View Download 0.330 N/A N/A c.110.1 D-Tyr tRNAtyr deacylase, DTD
View Download 0.327 N/A N/A a.24.16 Nucleotidyltransferase substrate binding subunit/domain
View Download 0.324 N/A N/A d.109.1 Actin depolymerizing proteins
View Download 0.303 N/A N/A f.14.1 Voltage-gated potassium channels
View Download 0.294 N/A N/A d.58.26 GHMP Kinase, C-terminal domain
View Download 0.291 N/A N/A c.102.1 Cell-division inhibitor MinC, N-terminal domain
View Download 0.283 N/A N/A d.58.12 eEF-1beta-like
View Download 0.278 N/A N/A f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.270 N/A N/A a.100.1 6-phosphogluconate dehydrogenase C-terminal domain-like
View Download 0.269 N/A N/A a.22.1 Histone-fold
View Download 0.267 N/A N/A a.73.1 Retrovirus capsid protein, N-terminal core domain
View Download 0.266 N/A N/A c.2.1 NAD(P)-binding Rossmann-fold domains
View Download 0.264 N/A N/A d.68.1 Translation initiation factor IF3, C-terminal domain
View Download 0.261 N/A N/A c.37.1 P-loop containing nucleoside triphosphate hydrolases
View Download 0.261 N/A N/A d.67.2 Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain
View Download 0.259 N/A N/A d.67.2 Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain
View Download 0.257 N/A N/A a.8.2 Plasmid maintenance system epsilon/zeta, antidote epsilon subunit
View Download 0.254 N/A N/A a.72.1 Functional domain of the splicing factor Prp18
View Download 0.253 N/A N/A c.30.1 PreATP-grasp domain
View Download 0.250 N/A N/A a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.248 N/A N/A a.4.1 Homeodomain-like
View Download 0.246 N/A N/A a.130.1 Chorismate mutase II
View Download 0.244 N/A N/A c.2.1 NAD(P)-binding Rossmann-fold domains
View Download 0.244 N/A N/A a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.243 N/A N/A c.50.1 Macro domain-like
View Download 0.241 N/A N/A a.74.1 Cyclin-like
View Download 0.240 N/A N/A d.110.4 SNARE-like
View Download 0.236 N/A N/A c.2.1 NAD(P)-binding Rossmann-fold domains
View Download 0.233 N/A N/A a.24.14 FAT domain of focal adhesion kinase
View Download 0.233 N/A N/A c.37.1 P-loop containing nucleoside triphosphate hydrolases
View Download 0.230 N/A N/A c.9.1 Barstar (barnase inhibitor)
View Download 0.226 N/A N/A d.108.1 Acyl-CoA N-acyltransferases (Nat)
View Download 0.225 N/A N/A c.53.1 Resolvase-like
View Download 0.223 N/A N/A c.58.1 Aminoacid dehydrogenase-like, N-terminal domain
View Download 0.223 N/A N/A c.2.1 NAD(P)-binding Rossmann-fold domains
View Download 0.216 N/A N/A a.63.1 Apolipophorin-III
View Download 0.208 N/A N/A d.217.1 SAND domain-like
View Download 0.205 N/A N/A d.110.4 SNARE-like
View Download 0.202 N/A N/A a.74.1 Cyclin-like
View Download 0.201 N/A N/A c.2.1 NAD(P)-binding Rossmann-fold domains


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle