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View Structure Prediction Details

Protein: DHR2
Organism: Saccharomyces cerevisiae
Length: 735 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for DHR2.

Description E-value Query
Range
Subject
Range
gi|114593352 - gi|114593352|ref|XP_001164599.1| PREDICTED: similar to Putative pre-mRNA-splicing factor ATP-depende...
DHX15 - DEAH (Asp-Glu-Ala-His) box polypeptide 15
0.0 [13..735] [69..777]
DEAH2_ARATH - Probable pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH2 OS=Arabidopsis thaliana GN=At3g62...
0.0 [56..735] [36..704]
mog-5 - RNA helicase status:Confirmed UniProt:Q09530 protein_id:AAC46765.1
0.0 [5..729] [455..1161]
FBpp0307849, CG1... - This gene is referred to in FlyBase by the symbol Dmel\CG11107 (CG11107, FBgn0033160). It is a prote...
gi|220947046 - gi|220947046|gb|ACL86066.1| CG11107-PA [synthetic construct]
0.0 [19..735] [2..710]
gi|12044832 - gi|12044832|gb|AAG33228.2|AF305070_1 DEAH-box RNA helicase [Chlamydomonas reinhardtii]
0.0 [1..728] [630..1355]

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Predicted Domain #1
Region A:
Residues: [1-487]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAANSNSRVA SNHTSKKQKV RRNIHPFTNN TRIKRASKIV KFNDSGEGDH VSDQRSNKEN  60
   61 VLTYKSLKSR ASDLLKMRET LPVYQHKREI MSYIESNPVT VLIGETGSGK STQIPQFVLE 120
  121 KLYDTKKHGS IAVTQPRRVA AINLATRVAQ EHGCKLGEQV GYSVRFDNTT TTRTRLKYLT 180
  181 DGMLLRELMM NSDLREYSVI VIDEAHERTV LTDLILGFLK SLIQGPRPDL RIIVMSATLQ 240
  241 AEKFSEFFNN APILFVEGRK FDVKQYYLKA PTDDIVDAVI RCCIQINQGE ELGDILCFLP 300
  301 GQEEIDKAVT IMEKIAKYVS DEAPVPLIVP YPLYAALPAV QQSLVFAPIK GFKRKVVFST 360
  361 NIAETSVTIS GVKFVVDSGL RKVKVWRHQL GLATLLTVPI SQASAMQRSG RAGRESEGKS 420
  421 FRLYCESDYV KLPKQSEPEI ARSDVTSPVL MLKRYGVDDL LNWTWFENPG KEAIVMGLQE 480
  481 LYELGAL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 75.30103
Match: 1fuuA_
Description: Initiation factor 4a
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
4.704140727858 bayes_pls_golite062009
binding 2.44689197844883 bayes_pls_golite062009
RNA binding 2.29590582680214 bayes_pls_golite062009
structural constituent of ribosome 1.57653963868443 bayes_pls_golite062009
RNA helicase activity 1.42791449104435 bayes_pls_golite062009
nucleic acid binding 1.41477043612798 bayes_pls_golite062009
RNA-dependent ATPase activity 1.39335733374328 bayes_pls_golite062009
ATP-dependent RNA helicase activity 1.36724390116598 bayes_pls_golite062009
DNA binding 1.11699929651302 bayes_pls_golite062009
catalytic activity 1.00104173493322 bayes_pls_golite062009
transcription regulator activity 0.989226939888218 bayes_pls_golite062009
mRNA binding 0.76699944561918 bayes_pls_golite062009
helicase activity 0.6191010101321 bayes_pls_golite062009
motor activity 0.61636596887462 bayes_pls_golite062009
structural molecule activity 0.596382945962261 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 0.461763181659193 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.458831409927227 bayes_pls_golite062009
pyrophosphatase activity 0.455976987338331 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.422944846459286 bayes_pls_golite062009
snRNA binding 0.418985924846052 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 0.338958888186454 bayes_pls_golite062009
purine NTP-dependent helicase activity 0.29664013896754 bayes_pls_golite062009
ATP-dependent helicase activity 0.29664013896754 bayes_pls_golite062009
translation release factor activity 0.178286731022211 bayes_pls_golite062009
translation termination factor activity 0.151456842619444 bayes_pls_golite062009
nucleotide binding 0.114848452385726 bayes_pls_golite062009
purine nucleotide binding 0.10713474095071 bayes_pls_golite062009
purine ribonucleotide binding 0.0916519414118148 bayes_pls_golite062009
ribonucleotide binding 0.0915913646217636 bayes_pls_golite062009
protein binding 0.071010918255742 bayes_pls_golite062009
transcription factor activity 0.0434163635422169 bayes_pls_golite062009
cytoskeletal protein binding 0.0272673919333979 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [488-544]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DTRGKITKRG QQMALLPLQP HLSSVLIKAS EVGCLSQVID IVSCLSVENL LLNPSPE

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [545-735]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ERDEVNERRL SLCNAGKRYG DLIMLKELFD IYFYELGKSQ DASSERNDWC KGLCISIRGF  60
   61 KNVIRVRDQL RVYCKRLFSS ISEEDEESKK IGEDGELISK ILKCFLTGFI KNTAIGMPDR 120
  121 SYRTVSTGEP ISIHPSSMLF MNKSCPGIMY TEYVFTTKGY ARNVSRIELS WLQEVVTNAA 180
  181 AVAKQKVSDS K

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle