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View Structure Prediction Details

Protein: YKL050C
Organism: Saccharomyces cerevisiae
Length: 922 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YKL050C.

Description E-value Query
Range
Subject
Range
MYH4_PIG - Myosin-4 OS=Sus scrofa GN=MYH4 PE=2 SV=1
4.0E-96 [3..749] [1144..1937]
MYH4_RABIT - Myosin-4 OS=Oryctolagus cuniculus GN=MYH4 PE=1 SV=1
6.0E-96 [3..749] [1145..1938]
MYH1 - myosin, heavy chain 1, skeletal muscle, adult
1.0E-95 [3..749] [1146..1939]
gi|8250661 - gi|8250661|gb|AAB29713.2| myosin heavy chain [Rattus sp.]
1.0E-95 [3..749] [99..892]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
2.0E-95 [3..749] [143..936]
gi|6683485 - gi|6683485|dbj|BAA89233.1| skeletal myosin heavy chain [Gallus gallus]
2.0E-95 [3..749] [1146..1939]

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Predicted Domain #1
Region A:
Residues: [1-72]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLISALQTT DVESVQTSPE QITERKAVRV STLQESLHSS EMHRAAPETP RSISNSVHKL  60
   61 KTIYSTYQQS GQ

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.693 a.2.2 Ribosomal protein L29 (L29p)
View Download 0.681 a.7.2 Enzyme IIa from lactose specific PTS, IIa-lac
View Download 0.580 a.7.7 BAG domain
View Download 0.564 a.4.1 Homeodomain-like
View Download 0.557 a.24.3 Cytochromes
View Download 0.538 a.60.1 SAM/Pointed domain
View Download 0.536 a.7.8 GAT domain
View Download 0.527 a.2.3 Chaperone J-domain
View Download 0.517 a.47.2 t-snare proteins
View Download 0.500 a.60.1 SAM/Pointed domain
View Download 0.497 a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.497 a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.493 a.23.1 HSC20 (HSCB), C-terminal oligomerisation domain
View Download 0.491 a.13.1 alpha-2-Macroglobulin receptor associated protein (RAP) domain 1
View Download 0.466 a.4.13 Sigma3 and sigma4 domains of RNA polymerase sigma factors
View Download 0.447 a.7.3 Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain
View Download 0.426 a.164.1 C-terminal domain of DFF45/ICAD (DFF-C domain)
View Download 0.414 a.4.11 RNA polymerase subunit RPB10
View Download 0.411 a.7.3 Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain
View Download 0.408 a.46.1 Methionine synthase domain
View Download 0.405 a.112.1 Description not found.
View Download 0.402 a.24.7 FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)
View Download 0.382 a.36.1 Signal peptide-binding domain
View Download 0.364 a.21.1 HMG-box
View Download 0.360 a.24.17 Group V grass pollen allergen
View Download 0.350 a.26.1 4-helical cytokines
View Download 0.344 a.30.2 Homodimeric domain of signal transducing histidine kinase
View Download 0.333 a.2.7 tRNA-binding arm
View Download 0.328 a.91.1 Regulator of G-protein signalling, RGS
View Download 0.313 a.4.9 Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3
View Download 0.312 a.17.1 p8-MTCP1
View Download 0.308 a.100.1 6-phosphogluconate dehydrogenase C-terminal domain-like
View Download 0.298 a.60.5 Barrier-to-autointegration factor, BAF
View Download 0.295 f.17.1 F1F0 ATP synthase subunit C
View Download 0.295 i.1.1 Ribosome and ribosomal fragments
View Download 0.286 d.188.1 Prokaryotic ribosomal protein L17
View Download 0.283 g.2.2 Neurotoxin B-IV
View Download 0.281 a.2.7 tRNA-binding arm
View Download 0.280 d.188.1 Prokaryotic ribosomal protein L17
View Download 0.279 a.8.2 Plasmid maintenance system epsilon/zeta, antidote epsilon subunit
View Download 0.278 a.1.1 Globin-like
View Download 0.277 a.4.6 C-terminal effector domain of the bipartite response regulators
View Download 0.272 a.4.1 Homeodomain-like
View Download 0.272 a.55.1 IHF-like DNA-binding proteins
View Download 0.270 a.60.2 RuvA domain 2-like
View Download 0.262 a.181.1 Antibiotic binding domain of TipA-like multidrug resistance regulators
View Download 0.261 a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.255 d.43.1 Elongation factor Ts (EF-Ts), dimerisation domain
View Download 0.249 a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.246 a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.245 a.4.5 "Winged helix" DNA-binding domain
View Download 0.244 a.36.1 Signal peptide-binding domain
View Download 0.236 d.49.1 Signal recognition particle alu RNA binding heterodimer, SRP9/14
View Download 0.234 a.28.1 ACP-like
View Download 0.233 a.29.4 RecG, N-terminal domain
View Download 0.227 f.34.1 Mechanosensitive channel protein MscS (YggB), transmembrane region
View Download 0.227 a.13.1 alpha-2-Macroglobulin receptor associated protein (RAP) domain 1
View Download 0.227 a.4.1 Homeodomain-like
View Download 0.224 a.16.1 S15/NS1 RNA-binding domain
View Download 0.224 a.112.1 Description not found.
View Download 0.220 a.4.1 Homeodomain-like
View Download 0.218 a.2.3 Chaperone J-domain
View Download 0.217 a.60.9 lambda integrase-like, N-terminal domain
View Download 0.214 a.4.1 Homeodomain-like
View Download 0.209 a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.208 a.177.1 Sigma2 domain of RNA polymerase sigma factors
View Download 0.208 a.76.1 Iron-dependent represor protein, dimerization domain
View Download 0.205 i.11.1 Computational models partly based on NMR data
View Download 0.201 a.74.1 Cyclin-like
View Download 0.200 a.45.1 Glutathione S-transferase (GST), C-terminal domain

Predicted Domain #2
Region A:
Residues: [73-395]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PLSKEAIFRA KQKYGILNTP ANYKTLGLGD SKSESVDLAA RLASKRTKVS PDDCVETAIE  60
   61 QKARGEAFKV TFSKIPLTPP EDVPITVNLG LKGRRDFLTR LAAQKALAFS PSLDNSMKGT 120
  121 SDSSSVKKKR FSGAPIGNEF DANLVNPQHP AGFKSLDLSK VLDGAERRAI SRVNDRLYPQ 180
  181 KVNFKNGLQS SDQSGVSKAN KEVFKKGTLE KLEHSAEQFL ESHAGNERQR LSDQQYMCAK 240
  241 GAADAVKDLD PKTLEDPDFA AREAQKKLYI KQVASPVVLN EAQKLANRKL QDIDSRDTYM 300
  301 LLFGNQAYNK LAVNIALQHY SVK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 13.154902
Match: 1i84S_
Description: Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [396-619]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QEEKKKIYLG GGLWMTPEEV NAVAKKLISP VVNEIDERAS RQRDVDKDIE RRSRVLDQEY  60
   61 EDGNSMERAK EQNDGQLLLA MASKQQQEKE AKKAEEGQRY DQFVQKMNIK LQQKEKELEN 120
  121 ARENRENLRN ELQERLSKNL SGENDELNDW NDACERDLKN SSIEHYYAVR SHFDNLGNSE 180
  181 RGYDELLEER SKIQVEIERL VASIAEHKTA IHGFGETADA GGAI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 8.045757
Match: 1c1gA_
Description: Tropomyosin
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [620-868]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PAVQKQKIPT RKDLLDATVN DPLVISAEMA KEEAEMATEE CMLKELQVDE MIIIRNIMLR  60
   61 ECEKKLEEEK ETAKRSRRGT EESKNNSNFS RDVIMSTPDN NEKVTPIGKS ASPKDVVKSR 120
  121 FLSTYNTGKD IDSSASARSI TGVSGVLDDG PKTPTSNKEN ELIDDEVKSY KVHQAVDGTG 180
  181 EDSIANKRDK SSRPAANSGG SITIEQFLFN KNADKQGLSK TESVTMKREP VVDQMDSKKG 240
  241 HDFTHCNDN

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [869-922]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GRRSFSGFSQ GSIENDYSNE VTDDQDDQEG SEIRVRDSND SNTSPKESFF KEVI

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.233 b.34.3 Myosin S1 fragment, N-terminal domain
View Download 0.219 d.47.1 Ribosomal protein L11, N-terminal domain


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle