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View Structure Prediction Details

Protein: PRI2
Organism: Saccharomyces cerevisiae
Length: 528 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PRI2.

Description E-value Query
Range
Subject
Range
PRI2 - Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair
PRI2_YEAST - DNA primase large subunit OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PRI2 PE=1 SV=1
0.0 [1..528] [1..528]
PRI2_MOUSE - DNA primase large subunit OS=Mus musculus GN=Prim2 PE=1 SV=1
0.0 [53..520] [20..464]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [53..520] [20..464]
PRI2_RAT - DNA primase large subunit OS=Rattus norvegicus GN=Prim2 PE=2 SV=1
0.0 [53..520] [20..464]
gi|9828626, gi|2... - gi|9828626|gb|AAG00249.1|AC002130_14 F1N21.14 [Arabidopsis thaliana], pir||G96696 protein F1N21.14 [...
0.0 [59..514] [316..759]
spp2 - DNA primase large subunit Spp2
PRI2_SCHPO - DNA primase large subunit OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=pri2 PE=1 SV=1
0.0 [38..507] [9..456]
gi|5679048 - gi|5679048|gb|AAD46835.1|AF160895_1 GM13640p [Drosophila melanogaster]
0.0 [55..516] [24..468]
gi|19170867, gi|... - gi|19173661|ref|NP_597464.1| DNA POLYMERASE ALPHA/PRIMASE LARGE SUBUNIT [Encephalitozoon cuniculi GB...
gi|19173661 - gi|19173661|ref|NP_597464.1| DNA POLYMERASE ALPHA/PRIMASE LARGE SUBUNIT [Encephalitozoon cuniculi GB...
2.0E-89 [124..479] [59..368]

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Predicted Domain #1
Region A:
Residues: [1-139]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFRQSKRRIA SRKNFSSYDD IVKSELDVGN TNAANQIILS SSSSEEEKKL YARLYESKLS  60
   61 FYDLPPQGEI TLEQFEIWAI DRLKILLEIE SCLSRNKSIK EIETIIKPQF QKLLPFNTES 120
  121 LEDRKKDYYS HFILRLCFC

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.946 N/A N/A a.185.1 Gametocyte protein Pfg27

Predicted Domain #2
Region A:
Residues: [140-220]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RSKELREKFV RAETFLFKIR FNMLTSTDQT KFVQSLDLPL LQFISNEEKA ELSHQLYQTV  60
   61 SASLQFQLNL NEEHQRKQYF Q

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.635 0.952 DNA replication initiation a.4.5 "Winged helix" DNA-binding domain

Predicted Domain #3
Region A:
Residues: [221-468]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QEKFIKLPFE NVIELVGNRL VFLKDGYAYL PQFQQLNLLS NEFASKLNQE LIKTYQYLPR  60
   61 LNEDDRLLPI LNHLSSGYTI ADFNQQKANQ FSENVDDEIN AQSVWSEEIS SNYPLCIKNL 120
  121 MEGLKKNHHL RYYGRQQLSL FLKGIGLSAD EALKFWSEAF TRNGNMTMEK FNKEYRYSFR 180
  181 HNYGLEGNRI NYKPWDCHTI LSKPRPGRGD YHGCPFRDWS HERLSAELRS MKLTQAQIIS 240
  241 VLDSCQKG

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [469-528]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EYTIACTKVF EMTHNSASAD LEIGEQTHIA HPNLYFERSR QLQKKQQKLE KEKLFNNGNH  60
   61 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle