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View Structure Prediction Details

Protein: COS5
Organism: Saccharomyces cerevisiae
Length: 383 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for COS5.

Description E-value Query
Range
Subject
Range
COS1 - Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-enc...
COS1_YEAST - Protein COS1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=COS1 PE=1 SV=1
599.0 [0..1] [380..1]

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Predicted Domain #1
Region A:
Residues: [1-61]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKENELKNEK SVDVLSFKQL ESQKIVLPQD LFRSSFTWFC YEIYKSLAFP IWMLLWLPLS  60
   61 V

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.495 N/A N/A a.60.1 SAM/Pointed domain
View Download 0.495 N/A N/A a.60.1 SAM/Pointed domain
View Download 0.469 N/A N/A b.34.2 SH3-domain
View Download 0.401 N/A N/A a.60.1 SAM/Pointed domain
View Download 0.360 N/A N/A a.60.12 DNA polymerase beta-like, second domain
View Download 0.349 N/A N/A a.60.1 SAM/Pointed domain
View Download 0.305 N/A N/A a.60.1 SAM/Pointed domain
View Download 0.242 N/A N/A a.77.1 DEATH domain
View Download 0.218 N/A N/A a.163.1 Crustacean CHH/MIH/GIH neurohormone
View Download 0.207 N/A N/A a.3.1 Cytochrome c

Predicted Domain #2
Region A:
Residues: [62-169]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 WWKLSNNCIY PLIVSLLVLF LGPIFVLVIC GLSRKRSLSK QLIQFCKEVT ENTPSSDPHD  60
   61 WEVVAANLNS YLYENKAWNT RYFFFNAMGC QEAFRTTLLE PFSLKKDE

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 52.275724
Match: PF00674
Description: DUP family

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.905 N/A N/A a.24.17 Group V grass pollen allergen
View Download 0.905 N/A N/A a.24.17 Group V grass pollen allergen
View Download 0.798 N/A N/A a.4.9 Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3
View Download 0.798 N/A N/A a.4.9 Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3
View Download 0.764 N/A N/A a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.748 N/A N/A a.74.1 Cyclin-like
View Download 0.744 N/A N/A a.186.1 Description not found.
View Download 0.740 N/A N/A a.29.2 Bromodomain
View Download 0.686 N/A N/A a.4.5 "Winged helix" DNA-binding domain

Predicted Domain #3
Region A:
Residues: [170-222]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AAKVKSFKDS VPYIEEALGV YFREVEKQWK LFNTEKSWSP VGLEDVQLPK DIH

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.807 d.58.17 Metal-binding domain
View Download 0.522 d.58.36 Sulfite reductase, domains 1 and 3
View Download 0.480 d.58.18 Regulatory domain in the aminoacid metabolism
View Download 0.460 d.58.17 Metal-binding domain
View Download 0.460 d.58.17 Metal-binding domain
View Download 0.445 d.58.17 Metal-binding domain
View Download 0.445 d.58.17 Metal-binding domain
View Download 0.385 d.58.10 Acylphosphatase-like
View Download 0.344 a.6.1 Putative DNA-binding domain

Predicted Domain #4
Region A:
Residues: [223-383]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RSKLTWFLKR IFTIYSLPLW LAFLNCICVS QHFCLAFRIL CPGLFFLMMV WLFQNMRTTA  60
   61 LLVKMEHKMQ FLLTIINEQE SGANGWDEIA RKMNRYLFEK KAWKNEEFFF EGIDCEWFFS 120
  121 HFFYRLLSAK KSMWLLPLNV ELWPYIKEAQ LSRNEESLMK K

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 58.920819
Match: PF00674
Description: DUP family

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle