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View Structure Prediction Details

Protein: CSN12
Organism: Saccharomyces cerevisiae
Length: 423 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CSN12.

Description E-value Query
Range
Subject
Range
CSN12 - Subunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-li...
gi|151945149 - gi|151945149|gb|EDN63400.1| COP9 signalosome (CSN) subunit [Saccharomyces cerevisiae YJM789]
CSN12_YEAST - Cop9 signalosome complex subunit 12 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CSN1...
0.0 [1..423] [1..423]
PCID2 - PCI domain containing 2
gi|55640145 - gi|55640145|ref|XP_509757.1| PREDICTED: hypothetical protein isoform 5 [Pan troglodytes]
4.0E-94 [23..420] [40..393]
PCID2-PA - The gene PCI domain-containing protein 2 is referred to in FlyBase by the symbol Dmel\PCID2 (CG7351,...
gi|220955898, gi... - gi|220955898|gb|ACL90492.1| CG7351-PA [synthetic construct], gi|220946198|gb|ACL85642.1| CG7351-PA [...
7.0E-86 [23..420] [39..391]
PSD3A_ARATH - 26S proteasome non-ATPase regulatory subunit 3 homolog A OS=Arabidopsis thaliana GN=RPN3A PE=1 SV=3
9.0E-85 [27..415] [95..418]

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Predicted Domain #1
Region A:
Residues: [1-103]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDVDIGCYFE EKRYDDKLLD FIRYDVKTPK KTKYILQRPT ATDEESVRLQ RFYQLGVDLK  60
   61 LKYSKRRSLK KQGRIKNATE ELLRLANEQL KLFNRIVERE TNW

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [104-423]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IIYPLWVMAK QLIRLANESS ELNKDSIEEC GRTIHRSFTI CLNDRNPRLN ENKKIGCYMF  60
   61 ANLEFSIYHR LSNKDMIKNL VKVLESRVNA RDIPPLNKSL AMEHKSQVVL YNYYLGQYYG 120
  121 CLENDHERGF FHLNEALLQC PMLYVESTGK FVLQGQMEKI MILLVPLALL TKRLYPHWDH 180
  181 PVIAGVITRS KRLSQVYPTL VRSVISGNLS LYEATAASHE RFFLSQGLHV VITLLREVVF 240
  241 TRLVQRCWQW GNDRKSIMPL KILLATKQHD SSANEDEEEQ LDALECRLAS AIASGLLRAY 300
  301 LSHSNRCIVF SKKEPFPHSK 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [356-423]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DRKSIMPLKI LLATKQHDSS ANEDEEEQLD ALECRLASAI ASGLLRAYLS HSNRCIVFSK  60
   61 KEPFPHSK

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.96
Match: 1ufmA
Description: Solution structure of the PCI domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.13436454849845 bayes_pls_golite062009
DNA binding 3.77959139017704 bayes_pls_golite062009
nucleic acid binding 3.61852605343839 bayes_pls_golite062009
binding 3.37660003833383 bayes_pls_golite062009
transcription factor activity 3.18366984273735 bayes_pls_golite062009
transcription repressor activity 2.13838000453063 bayes_pls_golite062009
sequence-specific DNA binding 1.67826024217505 bayes_pls_golite062009
transcription activator activity 1.36268391567196 bayes_pls_golite062009
RNA polymerase II transcription factor activity 1.01831614309793 bayes_pls_golite062009
protein binding 0.726445167461826 bayes_pls_golite062009
RNA binding 0.309381817803407 bayes_pls_golite062009
transcription factor binding 0.0307736199991748 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle