YRC Public Data Repository - Protein Structure Prediction

Protein:	ILV3
Organism:	Saccharomyces cerevisiae
Length:	585 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ILV3.

Description	E-value	Query Range	Subject Range
ILVD_AQUAE - Dihydroxy-acid dehydratase OS=Aquifex aeolicus GN=ilvD PE=3 SV=1 ILVD_AQUAE - Dihydroxy-acid dehydratase OS=Aquifex aeolicus (strain VF5) GN=ilvD PE=3 SV=1	0.0	[23..585]	[1..555]
ILV3 - Dihydroxyacid dehydratase, catalyzes third step in the common pathway leading to biosynthesis of bra... ILV3_YEAST - Dihydroxy-acid dehydratase, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) G...	0.0	[1..585]	[1..585]
gi\|2634607, gi\|1... - gi\|2634607\|emb\|CAB14105.1\| dihydroxy-acid dehydratase [Bacillus subtilis subsp. subtilis str. 168], ... ILVD_BACSU - Dihydroxy-acid dehydratase OS=Bacillus subtilis GN=ilvD PE=1 SV=3	0.0	[26..583]	[5..556]
ILVD_PYRAB - Dihydroxy-acid dehydratase OS=Pyrococcus abyssi GN=ilvD PE=3 SV=1 ILVD_PYRAB - Dihydroxy-acid dehydratase OS=Pyrococcus abyssi (strain GE5 / Orsay) GN=ilvD PE=3 SV=1	0.0	[26..583]	[2..549]
ILVD_HAEIN - Dihydroxy-acid dehydratase OS=Haemophilus influenzae GN=ilvD PE=3 SV=1 ILVD_HAEIN - Dihydroxy-acid dehydratase OS=Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) GN=...	0.0	[24..584]	[3..607]
ILVD_BACHD - Dihydroxy-acid dehydratase OS=Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM... ILVD_BACHD - Dihydroxy-acid dehydratase OS=Bacillus halodurans GN=ilvD PE=3 SV=1	0.0	[26..583]	[2..553]
gi\|226838675, gi... - gi\|254038984\|ref\|ZP_04873035.1\| dihydroxyacid dehydratase [Escherichia sp. 1_1_43], gi\|226838675\|gb\|... ILVD_ECOBW - Dihydroxy-acid dehydratase OS=Escherichia coli (strain K12 / MC4100 / BW2952) GN=ilvD PE=3 SV=1 gi\|188488835, gi... - gi\|75512668\|ref\|ZP_00735180.1\| COG0129: Dihydroxyacid dehydratase/phosphogluconate dehydratase [Esch... EG10496 - dihydroxyacid dehydratase / Dihydroxyacid dehydratase; homodimeric ILVD_ECOLI - Dihydroxy-acid dehydratase (EC 4.2.1.9) (DAD) - Escherichia coli gi\|85676276, gi\|... - gi\|89110245\|ref\|AP_004025.1\| dihydroxyacid dehydratase [Escherichia coli str. K-12 substr. W3110], g... EG10496 - dihydroxyacid dehydratase / Dihydroxyacid dehydratase; homodimeric	0.0	[24..584]	[3..610]
gi\|209753578, gi... - pir\|\|B86063 dihydroxyacid dehydratase [imported] - Escherichia coli (strain O157:H7, substrain EDL9... gi\|15804362, gi\|... - gi\|15804362\|ref\|NP_290402.1\| dihydroxy-acid dehydratase [Escherichia coli O157:H7 EDL933], gi\|125186... ILVD_ECO57 - Dihydroxy-acid dehydratase OS=Escherichia coli O157:H7 GN=ilvD PE=3 SV=3 gi\|15833959, gi\|... - gi\|15833959\|ref\|NP_312732.1\| dihydroxy-acid dehydratase [Escherichia coli O157:H7 str. Sakai], gi\|13... gi\|208740271, gi... - gi\|208820148\|ref\|ZP_03260468.1\| dihydroxy-acid dehydratase [Escherichia coli O157:H7 str. EC4042], g... gi\|208735016, gi... - gi\|208813739\|ref\|ZP_03255068.1\| dihydroxy-acid dehydratase [Escherichia coli O157:H7 str. EC4045], g... gi\|217326565, gi... - gi\|217326565\|ref\|ZP_03442649.1\| dihydroxy-acid dehydratase [Escherichia coli O157:H7 str. TW14588], ... ILVD_ECO5E - Dihydroxy-acid dehydratase OS=Escherichia coli O157:H7 (strain EC4115 / EHEC) GN=ilvD PE=3 SV=1 gi\|189376788, gi... - gi\|189376788\|gb\|EDU95204.1\| dihydroxy-acid dehydratase [Escherichia coli O157:H7 str. EC508], gi\|168... gi\|189373255, gi... - gi\|189373255\|gb\|EDU91671.1\| dihydroxy-acid dehydratase [Escherichia coli O157:H7 str. EC869], gi\|168... gi\|208726056, gi... - gi\|208806255\|ref\|ZP_03248592.1\| dihydroxy-acid dehydratase [Escherichia coli O157:H7 str. EC4206], g... gi\|195938060 - gi\|195938060\|ref\|ZP_03083442.1\| dihydroxy-acid dehydratase [Escherichia coli O157:H7 str. EC4024] gi\|189362687, gi... - gi\|189362687\|gb\|EDU81106.1\| dihydroxy-acid dehydratase [Escherichia coli O157:H7 str. EC4486], gi\|16... gi\|189365809, gi... - gi\|189365809\|gb\|EDU84225.1\| dihydroxy-acid dehydratase [Escherichia coli O157:H7 str. EC4501], gi\|16... gi\|168780667, gi... - gi\|189001570\|gb\|EDU70556.1\| dihydroxy-acid dehydratase [Escherichia coli O157:H7 str. EC4076], gi\|16... gi\|187768890, gi... - gi\|187768890\|gb\|EDU32734.1\| dihydroxy-acid dehydratase [Escherichia coli O157:H7 str. EC4196], gi\|16... gi\|189359330, gi... - gi\|189359330\|gb\|EDU77749.1\| dihydroxy-acid dehydratase [Escherichia coli O157:H7 str. EC4401], gi\|16... gi\|188014282, gi... - gi\|188014282\|gb\|EDU52404.1\| dihydroxy-acid dehydratase [Escherichia coli O157:H7 str. EC4113], gi\|16... gi\|254795770, gi... - gi\|254795770\|ref\|YP_003080607.1\| dihydroxyacid dehydratase [Escherichia coli O157:H7 str. TW14359], ...	0.0	[24..584]	[3..610]
ILVD_PASMU - Dihydroxy-acid dehydratase OS=Pasteurella multocida (strain Pm70) GN=ilvD PE=3 SV=1 ILVD_PASMU - Dihydroxy-acid dehydratase OS=Pasteurella multocida GN=ilvD PE=3 SV=1	0.0	[24..584]	[3..607]
ILVD_RHIME - Dihydroxy-acid dehydratase OS=Rhizobium meliloti GN=ilvD PE=3 SV=1 ILVD_RHIME - Dihydroxy-acid dehydratase OS=Rhizobium meliloti (strain 1021) GN=ilvD PE=3 SV=1	0.0	[25..584]	[4..608]

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Predicted Domain #1

Region A:
Residues: [1-100]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGLLTKVATS RQFSTTRCVA KKLNKYSYII TEPKGQGASQ AMLYATGFKK EDFKKPQVGV  60
   61 GSCWWSGNPC NMHLLDLNNR CSQSIEKAGL KAMQFNTIGV

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	9.48
Match:	1b8fA
Description:	Histidine ammonia-lyase (HAL)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
3-isopropylmalate dehydratase activity	5.35660492472618	bayes_pls_golite062009
catalytic activity	1.61959327305722	bayes_pls_golite062009
carbon-oxygen lyase activity	1.16841092671386	bayes_pls_golite062009
hydro-lyase activity	1.13002130445077	bayes_pls_golite062009
lyase activity	1.11228159918123	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [101-130]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SDGISMGTKG MRYSLQSREI IADSFETIMM

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [396-585]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SHPIKANGHL QILYGSLAPG GAVGKITGKE GTYFKGRARV FEEEGAFIEA LERGEIKKGE  60
   61 KTVVVIRYEG PRGAPGMPEM LKPSSALMGY GLGKDVALLT DGRFSGGSHG FLIGHIVPEA 120
  121 AEGGPIGLVR DGDEIIIDAD NNKIDLLVSD KEMAQRKQSW VAPPPRYTRG TLSKYAKLVS 180
  181 NASNGCVLDA

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	8.9
Match:	1o0uA
Description:	Putative glycerate kinase (hypothetical protein TM1585)
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [131-395]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AQHYDANIAI PSCDKNMPGV MMAMGRHNRP SIMVYGGTIL PGHPTCGSSK ISKNIDIVSA  60
   61 FQSYGEYISK QFTEEEREDV VEHACPGPGS CGGMYTANTM ASAAEVLGLT IPNSSSFPAV 120
  121 SKEKLAECDN IGEYIKKTME LGILPRDILT KEAFENAITY VVATGGSTNA VLHLVAVAHS 180
  181 AGVKLSPDDF QRISDTTPLI GDFKPSGKYV MADLINVGGT QSVIKYLYEN NMLHGNTMTV 240
  241 TGDTLAERAK KAPSLPEGQE IIKPL

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	8.9
Match:	1o0uA
Description:	Putative glycerate kinase (hypothetical protein TM1585)
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: