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View Structure Prediction Details

Protein: APL1
Organism: Saccharomyces cerevisiae
Length: 700 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for APL1.

Description E-value Query
Range		 Subject
Range
gi|173202 - gi|173202|gb|AAA35226.1| clathryn-associated protein complex [Saccharomyces cerevisiae]
 0.0 [1..700] [1..700]
AP2B1_MOUSE - AP-2 complex subunit beta OS=Mus musculus GN=Ap2b1 PE=1 SV=1
 0.0 [1..627] [1..608]
AP2B1 - adaptor-related protein complex 2, beta 1 subunit
gi|149724034 - gi|149724034|ref|XP_001503976.1| PREDICTED: similar to beta-chain clathrin associated protein comple...
AP2B1_RAT - AP-2 complex subunit beta OS=Rattus norvegicus GN=Ap2b1 PE=1 SV=1
gi|73966773 - gi|73966773|ref|XP_867698.1| PREDICTED: similar to Adapter-related protein complex 2 beta 1 subunit ...
gi|114668040, gi... - gi|114668042|ref|XP_001174162.1| PREDICTED: adaptor-related protein complex 2, beta 1 subunit isofor...
gi|168277614 - gi|168277614|dbj|BAG10785.1| AP-2 complex subunit beta-1 [synthetic construct]
 0.0 [1..647] [1..624]
gi|114668030, gi... - gi|114668032|ref|XP_001174152.1| PREDICTED: similar to beta-chain clathrin associated protein comple...
gi|149053660, gi... - gi|73695330|gb|AAI03482.1| Ap2b1 protein [Rattus norvegicus], gi|203115|gb|AAA40808.1| beta-chain cl...
gi|73966805 - gi|73966805|ref|XP_853723.1| PREDICTED: similar to adaptor-related protein complex 2, beta 1 subunit...
ENSCJAT00000029066 - null
gi|119600547, gi... - gi|71773106|ref|NP_001025177.1| adaptor-related protein complex 2, beta 1 subunit isoform a [Homo sa...
gi|123993213, gi... - gi|124000207|gb|ABM87612.1| adaptor-related protein complex 2, beta 1 subunit [synthetic construct],...
gi|149724032 - gi|149724032|ref|XP_001503974.1| PREDICTED: similar to beta-chain clathrin associated protein comple...
CCDS32621.1_1 - null
 0.0 [1..647] [1..624]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 0.0 [3..691] [5..683]
gi|220952014 - gi|220952014|gb|ACL88550.1| Bap-PA [synthetic construct]
Bap-PA - The gene Ã?ŽÃ?’ Adaptin is referred to in FlyBase by the symbol Dmel\Bap (CG12532, FBgn001...
 0.0 [1..656] [1..631]

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Predicted Domain #1
Region A:
Residues: [1-97] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDQKVFARY KANEIVTDLQ HFGVKKFKSN ITRRKNALRK IIANLVLGNY GEMSVLFSEL  60
   61 LKFWQIEDDL EVKRICHEYI RVIGALKPQQ AREALPF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 745.0103
Match: 1gw5B_
Description: Adaptin beta subunit N-terminal fragment
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [98-205] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IMDDFKSRDE KLQIMALRTL VLVPVKELSD QAFDCIISLV NHKSPPEQVT RTAIYALLDL  60
   61 DEIDHERVLG LSSILHDIVK AQSSSPEVIV AALHTLYSIH EKNANMEP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 745.0103
Match: 1gw5B_
Description: Adaptin beta subunit N-terminal fragment
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [206-341] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FRIPLELAFD MLELLPELNE WNKATVLEVL TTSVVPQHYL DTHEMIELAL PYLQQVNTYV  60
   61 VLNSLKFIMY LLNYVDVIKE TLAEKLSNSV IALLDKPPEL QFLVLRNVIL LLLSRESSLL 120
  121 RLDISYFFIE YNDPIY

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [570-611] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNTKLDPTVL EELELNIGTI VSIYLKPVSH IFRLNKTKLL PQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 745.0103
Match: 1gw5B_
Description: Adaptin beta subunit N-terminal fragment
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [342-434] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IKDTKLECLY LLANKETLPR ILEELEQYAT DIDIQMSRKS VRAIGNLAVK LDEDSVHDCV  60
   61 AVLLDLLEFG VDYVVQEIIS VFRNILRKYP NNF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 745.0103
Match: 1gw5B_
Description: Adaptin beta subunit N-terminal fragment
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [435-569] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KANVTELVKH TEVVQEPESK NAMIWIITQY SDVIPNYLEL FRVFSSNMFS ETLEVQFSIL  60
   61 NSAIKFFIRS PTKETEELCM DLLKGCIDHE NNPDLRDKTL MYWRLLSLTK TSRISNAITF 120
  121 ESLKSVLDGE LPLIE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 745.0103
Match: 1gw5B_
Description: Adaptin beta subunit N-terminal fragment
Matching Structure (courtesy of the PDB):

Predicted Domain #6
Region A:
Residues: [612-700] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SPILNPNKDL LPVVGNSFPP TGANRDRQNS ESQSSTKSRK TAMMDDYDKP AEKINQLKGK  60
   61 RKSSSNNPSK LSRKPSTLLR KLSMKRPFS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle