YRC Public Data Repository - Protein Structure Prediction

Protein:	SWE1
Organism:	Saccharomyces cerevisiae
Length:	819 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SWE1.

Description	E-value	Query Range	Subject Range
SWE1_YEAST - Mitosis inhibitor protein kinase SWE1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SW... SWE1 - Protein kinase that regulates the G2/M transition by inhibition of Cdc28p kinase activity; localizes...	0.0	[1..819]	[1..819]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	0.0	[106..775]	[106..759]
gi\|45384254, gi\|... - gi\|45384254\|ref\|NP_990386.1\| AKT1 kinase [Gallus gallus], gi\|2745889\|gb\|AAB94767.1\| serine/threonine...	0.0	[281..775]	[5..476]
AKT_MLVAT - AKT kinase-transforming protein OS=AKT8 murine leukemia virus GN=V-AKT PE=1 SV=1	0.0	[281..775]	[26..497]
AKT1_MOUSE - RAC-alpha serine/threonine-protein kinase OS=Mus musculus GN=Akt1 PE=1 SV=2 gi\|117616188, gi... - gi\|117616190\|gb\|ABK42113.1\| AKT [synthetic construct], gi\|117616188\|gb\|ABK42112.1\| Akt1 [synthetic c...	0.0	[281..775]	[5..476]
AKT1_RAT - RAC-alpha serine/threonine-protein kinase OS=Rattus norvegicus GN=Akt1 PE=1 SV=1	0.0	[281..775]	[5..476]
AKT1 - v-akt murine thymoma viral oncogene homolog 1 gi\|190690397, gi... - gi\|208965678\|dbj\|BAG72853.1\| v-akt murine thymoma viral oncogene homolog 1 [synthetic construct], gi...	0.0	[281..775]	[5..476]
AKT1_XENLA - RAC-alpha serine/threonine-protein kinase OS=Xenopus laevis GN=akt1 PE=2 SV=1	0.0	[281..775]	[5..477]

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Predicted Domain #1

Region A:
Residues: [1-400]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSLDEDEED FEMLDTENLQ FMGKKMFGKQ AGEDESDDFA IGGSTPTNKL KFYPYSNNKL  60
   61 TRSTGTLNLS LSNTALSEAN SKFLGKIEEE EEEEEEGKDE ESVDSRIKRW SPFHENESVT 120
  121 TPITKRSAEK TNSPISLKQW NQRWFPKNDA RTENTSSSSS YSVAKPNQSA FTSSGLVSKM 180
  181 SMDTSLYPAK LRIPETPVKK SPLVEGRDHK HVHLSSSKNA SSSLSVSPLN FVEDNNLQED 240
  241 LLFSDSPSSK ALPSIHVPTI DSSPLSEAKY HAHDRHNNQT NILSPTNSLV TNSSPQTLHS 300
  301 NKFKKIKRAR NSVILKNREL TNSLQQFKDD LYGTDENFPP PIIISSHHST RKNPQPYQFR 360
  361 GRYDNDTDEE ISTPTRRKSI IGATSQTHRE SRPLSLSSAI

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [401-499]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VTNTTSAETH SISSTDSSPL NSKRRLISSN KLSANPDSHL FEKFTNVHSI GKGQFSTVYQ  60
   61 VTFAQTNKKY AIKAIKPNKY NSLKRILLEI KILNEVTNQ

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [513-529]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YISSWKFQNS YYIMTEL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	261.218487
Match:	1fotA_
Description:	cAMP-dependent PK, catalytic subunit
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [500-512]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ITMDQEGKEY IID

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [530-748]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CENGNLDGFL QEQVIAKKKR LEDWRIWKII VELSLALRFI HDSCHIVHLD LKPANVMITF  60
   61 EGNLKLGDFG MATHLPLEDK SFENEGDREY IAPEIISDCT YDYKADIFSL GLMIVEIAAN 120
  121 VVLPDNGNAW HKLRSGDLSD AGRLSSTDIH SESLFSDITK VDTNDLFDFE RDNISGNSNN 180
  181 AGTSTVHNNS NINNPNMNNG NDNNNVNTAA TKNRLILHK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	261.218487
Match:	1fotA_
Description:	cAMP-dependent PK, catalytic subunit
Matching Structure (courtesy of the PDB):

Predicted Domain #4

Region A:
Residues: [749-819]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSKIPAWVPK FLIDGESLER IVRWMIEPNY ERRPTANQIL QTEECLYVEM TRNAGAIIQE  60
   61 DDFGPKPKFF I

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.563	0.925	regulation of cyclin-dependent protein kinase activity	a.74.1	Cyclin-like

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits