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View Structure Prediction Details

Protein: YAK1
Organism: Saccharomyces cerevisiae
Length: 807 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YAK1.

Description E-value Query
Range
Subject
Range
YAK1_YEAST - Dual specificity protein kinase YAK1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=YAK...
YAK1 - Serine-threonine protein kinase that is part of a glucose-sensing system involved in growth control ...
0.0 [1..807] [1..807]
pom1 - DYRK family protein kinase Pom1
POM1_SCHPO - Dual specificity protein kinase pom1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=pom1 ...
0.0 [2..759] [300..1053]
ppk5 - serine /threonine protein kinase Ppk5
PPK5_SCHPO - Serine/threonine-protein kinase ppk5 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=ppk5 ...
0.0 [11..652] [156..813]
mbk-1 - serine\/threonine kinase (2 domains) status:Confirmed UniProt:Q8WQL7 protein_id:CAA93756.2
0.0 [56..776] [11..722]
gi|117616342 - gi|117616342|gb|ABK42189.1| Dyrk3 [synthetic construct]
DYRK3_MOUSE - Dual specificity tyrosine-phosphorylation-regulated kinase 3 OS=Mus musculus GN=Dyrk3 PE=1 SV=1
0.0 [180..768] [2..572]
DYRK3 - dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
0.0 [180..768] [2..574]
gi|28922401, gi|... - gi|32412888|ref|XP_326924.1| hypothetical protein [Neurospora crassa], gi|28922401|gb|EAA31635.1| co...
gi|85099941 - gi|85099941|ref|XP_960871.1| hypothetical protein NCU06638 [Neurospora crassa OR74A]
0.0 [1..772] [442..1205]

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Predicted Domain #1
Region A:
Residues: [1-339]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNSSNNNDSS SSNSNMNNSL SPTLVTHSDA SMGSGRASPD NSHMGRGIWN PSYVNQGSQR  60
   61 SPQQQHQNHH QQQQQQQQQQ QQNSQFCFVN PWNEEKVTNS QQNLVYPPQY DDLNSNESLD 120
  121 AYRRRKSSLV VPPARAPAPN PFQYDSYPAY TSSNTSLAGN SSGQYPSGYQ QQQQQVYQQG 180
  181 AIHPSQFGSR FVPSLYDRQD FQRRQSLAAT NYSSNFSSLN SNTNQGTNSI PVMSPYRRLS 240
  241 AYPPSTSPPL QPPFKQLRRD EVQGQKLSIP QMQLCNSKND LQPVLNATPK FRRASLNSKT 300
  301 ISPLVSVTKS LITTYSLCSP EFTYQTSKNP KRVLTKPSE

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [340-451]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GKCNNGFDNI NSDYILYVND VLGVEQNRKY LVLDILGQGT FGQVVKCQNL LTKEILAVKV  60
   61 VKSRTEYLTQ SITEAKILEL LNQKIDPTNK HHFLRMYDSF VHKNHLCLVF EL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 434.0
Match: 1aq1__
Description: Cyclin-dependent PK, CDK2
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [452-531]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LSNNLYELLK QNKFHGLSIQ LIRTFTTQIL DSLCVLKESK LIHCDLKPEN ILLCAPDKPE  60
   61 LKIIDFGSSC EEARTVYTYI 

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [655-661]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RYPKSIQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 434.0
Match: 1aq1__
Description: Cyclin-dependent PK, CDK2
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [532-581]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QSRFYRAPEI ILGIPYSTSI DMWSLGCIVA ELFLGIPIFP GASEYNQLTR 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 434.0
Match: 1aq1__
Description: Cyclin-dependent PK, CDK2
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [582-654]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IIDTLGYPPS WMIDMGKNSG KFMKKLAPEE SSSSTQKHRM KTIEEFCREY NIVEKPSKQY  60
   61 FKWRKLPDII RNY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 434.0
Match: 1aq1__
Description: Cyclin-dependent PK, CDK2
Matching Structure (courtesy of the PDB):

Predicted Domain #6
Region A:
Residues: [662-807]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NSQELIDQEM QNRECLIHFL GGVLNLNPLE RWTPQQAMLH PFITKQEFTG EWFPPGSSLP  60
   61 GPSEKHDDAK GQQSEYGSAN DSSNNAGHNY VYNPSSATGG ADSVDIGAIS KRKENTSGDI 120
  121 SNNFAVTHSV QEGPTSAFNK LHIVEE

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 10.52
Match: 1i09A
Description: Glycogen synthase kinase-3 beta (Gsk3b)
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle