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View Structure Prediction Details

Protein: ALY2
Organism: Saccharomyces cerevisiae
Length: 1046 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ALY2.

Description E-value Query
Range
Subject
Range
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [1..1046] [1..1046]
ALY2 - Protein proposed to regulate the endocytosis of plasma membrane proteins; interacts with the cyclin ...
ALY2_YEAST - Arrestin-related trafficking adapter 3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=A...
0.0 [1..1046] [1..1046]
gi|16554449, gi|... - gi|16554449|ref|NP_003377.1| zonadhesin isoform 3 [Homo sapiens], gi|12667414|gb|AAK01433.1|AF332977...
1.0E-55 [576..1045] [516..1010]

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Predicted Domain #1
Region A:
Residues: [1-241]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPMDQSISSP LFPMEKDIDI PLDATPLAQS SSLQLFIHLA EPVVFLQGFD PQKTEYPSVV  60
   61 LRGCLVVRIL KPTKLKSISL SFKGYSRTEW PEGIPPKRQE FVEIKDIVDH TWALYPPTEQ 120
  121 KSKKKMDASA PNESNNAANN FLTKESGASL YRTLSDNETI TSRKNSISGL SSLNLSPLGA 180
  181 PGNSSVNVKD RESRQRSRSS SVTSSNGPSR NLSPINLLKR ATSPSVSHHN YKPTTTSIFS 240
  241 D

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [242-433]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LLNNTFTHND AASHHGHHIP TSSNHLAMTS NNFTSGSGGE FFVFQPGDYI YAFEELIPQA  60
   61 YPESIKADFG FVEYFLFASI ERPGAFKSNI SARQVVNIVR TQAHNSVEES EPIIISRDWE 120
  121 NQLYYDIVIA SKDIILDAFL PITFKFAPLD KVTLHRIRIY VTETMEYYCR EKKVHRMEPT 180
  181 KKFLLTEQKG PK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 10.221849
Match: 1jsyA_
Description: Arrestin
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [434-1046]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LPNLPNDANL SKAKNMGNLL QDPKNGDLVN KEYEYQIFIP SRFNNHQQLH PDTSYENIKA  60
   61 NHWIKICLRL SRVVDNKRKH YEISIDSPIH VLHRLCSHAN TLLPSYDGHP ASFPKETDSS 120
  121 ISSILESSDD NINLYHNSNI FFPKEVLSSP VLSPNVQPLD ILIPHLPSTS LTRNSRQFNR 180
  181 NSKSHPSDNT IFNSAKLKSN IYQPESLQRE LASPQAIPLS PITSPMSNME VPPPDFDFSS 240
  241 DFISDAASGT TTTEVSSSES SILPRDPPSY KDTVLHDNNQ KRRPNSKHPT PPSLKASHPN 300
  301 KNSDKNSSET LNKKESMSKI EENKHKRETT PKKRENRDVK SLSTPQREES KDSTSTGNQS 360
  361 NEKNRKRVLS LSSSLHSSPN NSGFAHSALG NLSNESLRSL NRRESVQDNL PSTIRHDNPF 420
  421 FTDLNQVLIE DELKNHDKNE LNRHSTNTSS TPASARSSFD YSGINISKDK LNMEPLLSKT 480
  481 ETLTNKVNED SFLRPNDSYV DLLEPSVDTT IDITAPYARN SSAWHPLQND NDNNQFSPLL 540
  541 GSNENFLNAA NAQNSAESDH NNDIFTQGSG LTESSKNSDS EERFISRLSS PEKVLINTLD 600
  601 NESGLQSINE STL

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
binding 0.637053679668866 bayes_pls_golite062009
protein binding 0.29496902337062 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [529-616]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CSHANTLLPS YDGHPASFPK ETDSSISSIL ESSDDNINLY HNSNIFFPKE VLSSPVLSPN  60
   61 VQPLDILIPH LPSTSLTRNS RQFNRNSK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [617-867]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SHPSDNTIFN SAKLKSNIYQ PESLQRELAS PQAIPLSPIT SPMSNMEVPP PDFDFSSDFI  60
   61 SDAASGTTTT EVSSSESSIL PRDPPSYKDT VLHDNNQKRR PNSKHPTPPS LKASHPNKNS 120
  121 DKNSSETLNK KESMSKIEEN KHKRETTPKK RENRDVKSLS TPQREESKDS TSTGNQSNEK 180
  181 NRKRVLSLSS SLHSSPNNSG FAHSALGNLS NESLRSLNRR ESVQDNLPST IRHDNPFFTD 240
  241 LNQVLIEDEL K

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [868-1046]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NHDKNELNRH STNTSSTPAS ARSSFDYSGI NISKDKLNME PLLSKTETLT NKVNEDSFLR  60
   61 PNDSYVDLLE PSVDTTIDIT APYARNSSAW HPLQNDNDNN QFSPLLGSNE NFLNAANAQN 120
  121 SAESDHNNDI FTQGSGLTES SKNSDSEERF ISRLSSPEKV LINTLDNESG LQSINESTL

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle