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View Structure Prediction Details

Protein: TDH1
Organism: Saccharomyces cerevisiae
Length: 332 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TDH1.

Description E-value Query
Range
Subject
Range
G3P_CRIGR - Glyceraldehyde-3-phosphate dehydrogenase OS=Cricetulus griseus GN=GAPDH PE=2 SV=2
0.0 [1..330] [1..330]
G3P_RAT - Glyceraldehyde-3-phosphate dehydrogenase OS=Rattus norvegicus GN=Gapdh PE=1 SV=3
0.0 [1..330] [1..330]
G3P_FELCA - Glyceraldehyde-3-phosphate dehydrogenase OS=Felis catus GN=GAPDH PE=2 SV=3
0.0 [1..330] [1..330]
GAPDH - glyceraldehyde-3-phosphate dehydrogenase
gi|55637711, gi|... - gi|55637711|ref|XP_508955.1| PREDICTED: glyceraldehyde-3-phosphate dehydrogenase isoform 5 [Pan trog...
gi|61362726, gi|... - gi|61362731|gb|AAX42271.1| glyceraldehyde-3-phosphate dehydrogenase [synthetic construct], gi|613627...
0.0 [2..330] [4..332]
G3P_MOUSE - Glyceraldehyde-3-phosphate dehydrogenase OS=Mus musculus GN=Gapdh PE=1 SV=2
0.0 [1..330] [1..330]
G3P_PIG - Glyceraldehyde-3-phosphate dehydrogenase OS=Sus scrofa GN=GAPDH PE=1 SV=4
0.0 [1..330] [1..330]
G3P_COTJA - Glyceraldehyde-3-phosphate dehydrogenase OS=Coturnix coturnix japonica GN=GAPDH PE=2 SV=2
gi|62616, gi|484434 - gi|62616|emb|CAA79512.1| glyceraldehydephosphate dehydrogenase [Coturnix coturnix], gi|484434|pir||J...
0.0 [1..330] [1..330]
G3P_CANLF - Glyceraldehyde-3-phosphate dehydrogenase OS=Canis lupus familiaris GN=GAPDH PE=2 SV=3
0.0 [1..330] [1..330]
G3P_CHICK - Glyceraldehyde-3-phosphate dehydrogenase OS=Gallus gallus GN=GAPDH PE=2 SV=3
0.0 [1..330] [1..330]

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Predicted Domain #1
Region A:
Residues: [1-147]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIRIAINGFG RIGRLVLRLA LQRKDIEVVA VNDPFISNDY AAYMVKYDST HGRYKGTVSH  60
   61 DDKHIIIDGV KIATYQERDP ANLPWGSLKI DVAVDSTGVF KELDTAQKHI DAGAKKVVIT 120
  121 APSSSAPMFV VGVNHTKYTP DKKIVSN

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [319-332]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SARVVDLIEY VAKA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1400.0
Match: 3gpdR_
Description: Glyceraldehyde-3-phosphate dehydrogenase (GAPDH)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
1-deoxy-D-xylulose-5-phosphate reductoisomerase activity 3.16750187025282 bayes_pls_golite062009
oxidoreductase activity 3.09625241707629 bayes_pls_golite062009
glucose-6-phosphate dehydrogenase activity 2.2713146106379 bayes_pls_golite062009
catalytic activity 1.79741889688267 bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors 1.65338499044318 bayes_pls_golite062009
DNA binding 1.61355789916908 bayes_pls_golite062009
transcription regulator activity 1.55390653047158 bayes_pls_golite062009
nucleic acid binding 1.48478425318425 bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 1.47309297191111 bayes_pls_golite062009
retinol dehydrogenase activity 1.16811519855038 bayes_pls_golite062009
glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity 1.0729055844832 bayes_pls_golite062009
glyceraldehyde-3-phosphate dehydrogenase activity 1.04861088194764 bayes_pls_golite062009
binding 0.982999356179965 bayes_pls_golite062009
transcription factor activity 0.91090893050278 bayes_pls_golite062009
signal transducer activity 0.910536752370264 bayes_pls_golite062009
molecular transducer activity 0.910536752370264 bayes_pls_golite062009
alcohol dehydrogenase (NAD) activity 0.88293430762998 bayes_pls_golite062009
NAD or NADH binding 0.74536049628503 bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity 0.527946013169731 bayes_pls_golite062009
hydrolase activity 0.41684292392606 bayes_pls_golite062009
receptor activity 0.388215697182664 bayes_pls_golite062009
coenzyme binding 0.35922330382799 bayes_pls_golite062009
structural molecule activity 0.345975336806588 bayes_pls_golite062009
alcohol dehydrogenase activity, zinc-dependent 0.331048046502169 bayes_pls_golite062009
collagen binding 0.30621400535957 bayes_pls_golite062009
transmembrane receptor activity 0.211380641599388 bayes_pls_golite062009
NADPH:quinone reductase activity 0.136079082491021 bayes_pls_golite062009
glucose binding 0.13030486887358 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [148-318]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ASCTTNCLAP LAKVINDAFG IEEGLMTTVH SMTATQKTVD GPSHKDWRGG RTASGNIIPS  60
   61 STGAAKAVGK VLPELQGKLT GMAFRVPTVD VSVVDLTVKL EKEATYDQIK KAVKAAAEGP 120
  121 MKGVLGYTED AVVSSDFLGD THASIFDASA GIQLSPKFVK LISWYDNEYG Y

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1400.0
Match: 3gpdR_
Description: Glyceraldehyde-3-phosphate dehydrogenase (GAPDH)
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle