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View Structure Prediction Details

Protein: MAD3
Organism: Saccharomyces cerevisiae
Length: 515 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MAD3.

Description E-value Query
Range
Subject
Range
MAD3 - Subunit of the spindle-assembly checkpoint complex, which delays anaphase onset in cells with defect...
MAD3_YEAST - Spindle assembly checkpoint component MAD3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) ...
0.0 [1..515] [1..515]
BU1B_MOUSE, BUB1... - Mitotic checkpoint serine/threonine-protein kinase BUB1 beta OS=Mus musculus GN=Bub1b PE=1 SV=1, (Q9...
0.0 [25..479] [14..503]
gi|2981235 - gi|2981235|gb|AAC06260.1| mitotic checkpoint kinase Mad3L [Homo sapiens]
0.0 [24..469] [20..502]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [24..469] [20..502]

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Predicted Domain #1
Region A:
Residues: [1-265]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKAYAKKRIS YMPSSPSQNV INFEEIETQK ENILPLKEGR SAAALSKAIH QPLVEINQVK  60
   61 SSFEQRLIDE LPALSDPITL YLEYIKWLNN AYPQGGNSKQ SGMLTLLERC LSHLKDLERY 120
  121 RNDVRFLKIW FWYIELFTRN SFMESRDIFM YMLRNGIGSE LASFYEEFTN LLIQKEKFQY 180
  181 AVKILQLGIK NKARPNKVLE DRLNHLLREL GENNIQLGNE ISMDSLESTV LGKTRSEFVN 240
  241 RLELANQNGT SSDVNLTKNN VFVDG

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 7.6
Match: 1fchA
Description: Peroxin pex5 (peroxisomal targeting signal 1 (PTS1) receptor)
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [266-389]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EESDVELFET PNRGVYRDGW ENFDLKAERN KENNLRISLL EANTNLGELK QHEMLSQKKR  60
   61 PYDEKLPIFR DSIGRSDPVY QMINTKDQKP EKIDCNFKLI YCEDEESKGG RLEFSLEEVL 120
  121 AISR

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [390-515]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NVYKRVRTNR KHPREANLGQ EESANQKEAE AQSKRPKISR KALVSKSLTP SNQGRMFSGE  60
   61 EYINCPMTPK GRSTETSDII SAVKPRQLTP ILEMRESNSF SQSKNSEIIS DDDKSSSSFI 120
  121 SYPPQR

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle