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View Structure Prediction Details

Protein: DSN1
Organism: Saccharomyces cerevisiae
Length: 576 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for DSN1.

Description E-value Query
Range
Subject
Range
gi|68388302 - gi|68388302|ref|XP_696268.1| PREDICTED: similar to slow myosin heavy chain 1 [Danio rerio]
365.0 [0..19] [576..2135]
gi|50757613 - gi|50757613|ref|XP_415578.1| PREDICTED: similar to myosin heavy chain [Gallus gallus]
297.0 [0..17] [574..1080]
gi|47940239 - gi|47940239|gb|AAH72094.1| LOC432141 protein [Xenopus laevis]
263.0 [0..173] [562..703]
MYH1_PIG - Myosin-1 OS=Sus scrofa GN=MYH1 PE=2 SV=1
261.0 [0..17] [574..1133]
MYH4_RABIT - Myosin-4 OS=Oryctolagus cuniculus GN=MYH4 PE=1 SV=1
261.0 [0..17] [574..1132]
gi|109113339 - gi|109113339|ref|XP_001118262.1| PREDICTED: myosin, heavy polypeptide 2, skeletal muscle, adult [Mac...
261.0 [0..17] [574..888]
MYH1_BOVIN - Myosin-1 OS=Bos taurus GN=MYH1 PE=2 SV=2
261.0 [0..17] [574..1132]

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Predicted Domain #1
Region A:
Residues: [1-77]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLEPTQTVS GTPPMLHQRT HKQVYPLRME TIPILESDSK ATLQSNEPTQ KDEEETEYFE  60
   61 NKQSVSNLSP DLKFKRH

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.875 d.58.18 Regulatory domain in the aminoacid metabolism

Predicted Domain #2
Region A:
Residues: [78-172]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KNKHIQGFPT LGERLDNLQD IKKAKRVENF NSSAPIADDN HSGDATANAT ANATANATAN  60
   61 VNASAMPAPY MPYYYYYHPM NAPTPAMIPY PGSPM

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 5.522879
Match: 1mmgA
Description: X-RAY STRUCTURES OF THE MGADP, MGATPGAMMAS, AND MGAMPPNP COMPLEXES OF THE DICTYOSTELIUM DISCOIDEUM MYOSIN MOTOR DOMAIN
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [173-350]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HSIMPNSSLQ PFYSQPTAAG GPDMTTPQNI SSSQQLLPAP QLFPYGSFHQ QQLQQPHYIQ  60
   61 RTRERKKSIG SQRGRRLSML ASQANGGSTI ISPHKDIPEE DFYTVVGNAS FGKNLQIRQL 120
  121 FNWCLMRSLH KLELKAKNQE EEGELEHLTK KSKLESTKAE TDYVDPKRLA MVIIKEFV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 44.0
Match: 1i84S
Description: Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [351-576]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DDLKKDHIAI DWEDEEKYED EDEEKILDNT ENYDDTELRQ LFQENDDDDD DDDEVDYSEI  60
   61 QRSRRKFSER RKALPKEPKK LLPNSKNVEN TKNLSILTSK VNAIKNEVKE WAVTLDTSRP 120
  121 DLEWQELTSF SSQPLEPLSD TEEPDLAIAD VETKLETKVD ELRYQSHILN SHSLALNEIT 180
  181 NSKVNKLNIE TMRKISSETD DDHSQVINPQ QLLKGLSLSF SKKLDL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 44.0
Match: 1i84S
Description: Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle