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View Structure Prediction Details

Protein: DPH1
Organism: Saccharomyces cerevisiae
Length: 425 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for DPH1.

Description E-value Query
Range
Subject
Range
DPH1_YEAST - Diphthamide biosynthesis protein 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=DPH1 ...
DPH1 - Protein required, along with Dph2p, Kti11p, Jjj3p, and Dph5p, for synthesis of diphthamide, which is...
0.0 [1..425] [1..425]
SPBC3B8.05 - diphthamide biosynthesis protein
DPH1_SCHPO - Diphthamide biosynthesis protein 1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=dph1 PE...
0.0 [8..415] [6..413]
gi|1438796 - gi|1438796|gb|AAB36421.1| OVCA1=candidate tumor suppressor [human, fetal brain, Peptide, 443 aa]
0.0 [43..415] [25..392]
dph-1 - diptheria toxin resistance protein status:Partially_confirmed UniProt:P49958 protein_id:CAA85493.1
0.0 [46..415] [2..369]
gi|220943026, gi... - gi|220953130|gb|ACL89108.1| CG11652-PA [synthetic construct], gi|220943026|gb|ACL84056.1| CG11652-PA...
CG11652-PB, CG11... - This gene is referred to in FlyBase by the symbol Dmel\CG11652 (CG11652, FBgn0036194). It is a prote...
0.0 [39..415] [29..403]
gi|10176920 - gi|10176920|dbj|BAB10164.1| unnamed protein product [Arabidopsis thaliana]
0.0 [39..402] [26..391]
DPH1_ENCCU - Diphthamide biosynthesis protein 1 OS=Encephalitozoon cuniculi (strain GB-M1) GN=DPH1 PE=3 SV=1
DPH1_ENCCU - Diphthamide biosynthesis protein 1 OS=Encephalitozoon cuniculi GN=DPH1 PE=3 SV=1
0.0 [59..416] [70..409]

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Predicted Domain #1
Region A:
Residues: [1-162]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSGSTESKKQ PRRRFIGRKS GNSNNDKLTT VAENGNEIIH KQKSRIALGR SVNHVPEDIL  60
   61 NDKELNEAIK LLPSNYNFEI HKTVWNIRKY NAKRIALQMP EGLLIYSLII SDILEQFCGV 120
  121 ETLVMGDVSY GACCIDDFTA RALDCDFIVH YAHSCLVPID VT

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.378 c.37.1 P-loop containing nucleoside triphosphate hydrolases
View Download 0.417 c.2.1 NAD(P)-binding Rossmann-fold domains
View Download 0.418 c.23.4 Succinyl-CoA synthetase domains
View Download 0.361 c.23.6 Cobalamin (vitamin B12)-binding domain
View Download 0.348 c.23.4 Succinyl-CoA synthetase domains
View Download 0.338 c.23.4 Succinyl-CoA synthetase domains
View Download 0.333 c.23.6 Cobalamin (vitamin B12)-binding domain
View Download 0.307 c.32.1 Tubulin/Dihydroxyacetone kinase nucleotide-binding domain
View Download 0.301 c.23.1 CheY-like
View Download 0.299 c.32.1 Tubulin/Dihydroxyacetone kinase nucleotide-binding domain
View Download 0.293 c.1.10 Aldolase
View Download 0.290 c.23.4 Succinyl-CoA synthetase domains
View Download 0.281 c.23.6 Cobalamin (vitamin B12)-binding domain
View Download 0.237 c.61.1 PRTase-like
View Download 0.236 c.1.2 Ribulose-phoshate binding barrel
View Download 0.233 c.1.2 Ribulose-phoshate binding barrel
View Download 0.230 c.78.2 Aspartate/glutamate racemase
View Download 0.228 c.23.1 CheY-like
View Download 0.225 c.1.10 Aldolase
View Download 0.223 c.1.2 Ribulose-phoshate binding barrel
View Download 0.222 a.29.3 Acyl-CoA dehydrogenase C-terminal domain-like
View Download 0.216 c.23.4 Succinyl-CoA synthetase domains
View Download 0.212 c.2.1 NAD(P)-binding Rossmann-fold domains

Predicted Domain #2
Region A:
Residues: [163-226]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KIKVLYVFVT INIQEDHIIK TLQKNFPKGS RIATFGTIQF NPAVHSVRDK LLNDEEHMLY  60
   61 IIPP

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [282-425]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RKFTREGYDQ KQLVEVRAEA IEVARKGKVF GLILGALGRQ GNLNTVKNLE KNLIAAGKTV  60
   61 VKIILSEVFP QKLAMFDQID VFVQVACPRL SIDWGYAFNK PLLTPYEASV LLKKDVMFSE 120
  121 KYYPMDYYEA KGYGRGETPK HAIE

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 7.04
Match: 1jzxK
Description: 50S subunit
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [227-281]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QIKPLSRGEV LGCTSERLDK EQYDAMVFIG DGRFHLESAM IHNPEIPAFK YDPYN

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 7.04
Match: 1jzxK
Description: 50S subunit
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle