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View Structure Prediction Details

Protein: LYS12
Organism: Saccharomyces cerevisiae
Length: 371 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for LYS12.

Description E-value Query
Range
Subject
Range
gi|125569901, gi... - gi|81686717|dbj|BAE48299.1| NAD-dependent isocitrate dehydrogenase a [Oryza sativa Japonica Group], ...
0.0 [1..371] [6..362]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [3..371] [13..364]
IDH5_ARATH - Isocitrate dehydrogenase [NAD] catalytic subunit 5, mitochondrial OS=Arabidopsis thaliana GN=IDH5 PE...
0.0 [5..371] [25..374]
gi|194204815, gi... - gi|195567723|ref|XP_002107408.1| GD15579 [Drosophila simulans], gi|194204815|gb|EDX18391.1| GD15579 ...
FBpp0307649 - type=protein; loc=X:complement(19413320..19413658,19413729..19413864,19413937..19414331,19414693..19...
0.0 [6..371] [30..377]
gi|107102667 - gi|107102667|ref|ZP_01366585.1| hypothetical protein PaerPA_01003732 [Pseudomonas aeruginosa PACS2]
gi|218890681, gi... - gi|218890681|ref|YP_002439545.1| 3-isopropylmalate dehydrogenase [Pseudomonas aeruginosa LESB58], gi...
gi|116051114, gi... - gi|46164051|ref|ZP_00136482.2| COG0473: Isocitrate/isopropylmalate dehydrogenase [Pseudomonas aerugi...
LEU3_PSEAE - 3-isopropylmalate dehydrogenase OS=Pseudomonas aeruginosa GN=leuB PE=3 SV=2
LEU3_PSEAE - 3-isopropylmalate dehydrogenase OS=Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 /...
gi|126195191, gi... - gi|84326201|ref|ZP_00974230.1| COG0473: Isocitrate/isopropylmalate dehydrogenase [Pseudomonas aerugi...
0.0 [23..371] [2..357]
gi|1314267 - gi|1314267|gb|AAC45419.1| 3-isopropylmalate dehydrogenase [Pseudomonas aeruginosa]
gi|1314267|gb|AA... - 3-isopropylmalate dehydrogenase [Pseudomonas aeruginosa]
0.0 [23..371] [2..357]
LEU3_AQUAE - 3-isopropylmalate dehydrogenase OS=Aquifex aeolicus (strain VF5) GN=leuB PE=3 SV=1
LEU3_AQUAE - 3-isopropylmalate dehydrogenase OS=Aquifex aeolicus GN=leuB PE=3 SV=1
0.0 [22..371] [2..356]
LYS12 - Homo-isocitrate dehydrogenase, an NAD-linked mitochondrial enzyme required for the fourth step in th...
LYS12_YEAST - Homoisocitrate dehydrogenase, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c)...
gi|190406305 - gi|190406305|gb|EDV09572.1| homo-isocitrate dehydrogenase [Saccharomyces cerevisiae RM11-1a]
gi|207344363 - gi|207344363|gb|EDZ71532.1| YIL094Cp-like protein [Saccharomyces cerevisiae AWRI1631]
0.0 [1..371] [1..371]
gi|229696789, gi... - gi|229840423|ref|ZP_04460582.1| 3-isopropylmalate dehydrogenase [Yersinia pestis biovar Orientalis s...
gi|229836879, gi... - gi|229836879|ref|ZP_04457044.1| 3-isopropylmalate dehydrogenase [Yersinia pestis Pestoides A], gi|22...
gi|229900758, gi... - gi|229900758|ref|ZP_04515882.1| 3-isopropylmalate dehydrogenase [Yersinia pestis Nepal516], gi|22968...
gi|229843036, gi... - gi|229843036|ref|ZP_04463186.1| 3-isopropylmalate dehydrogenase [Yersinia pestis biovar Orientalis s...
gi|21960620, gi|... - gi|22127520|ref|NP_670943.1| 3-isopropylmalate dehydrogenase [Yersinia pestis KIM], gi|21960620|gb|A...
gi|25283830 - gi|25283830|pir||AB0066 3-isopropylmalate dehydrogenase (EC 1.1.1.85) [imported] - Yersinia pestis (...
gi|16120861, gi|... - gi|16120861|ref|NP_404174.1| 3-isopropylmalate dehydrogenase [Yersinia pestis CO92], gi|15978625|emb...
gi|150260432, gi... - gi|150260432|ref|ZP_01917160.1| 3-isopropylmalate dehydrogenase [Yersinia pestis CA88-4125], gi|1492...
gi|45443382, gi|... - gi|45443382|ref|NP_994921.1| 3-isopropylmalate dehydrogenase [Yersinia pestis biovar Microtus str. 9...
0.0 [20..369] [3..359]

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Predicted Domain #1
Region A:
Residues: [1-371]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFRSVATRLS ACRGLASNAA RKSLTIGLIP GDGIGKEVIP AGKQVLENLN SKHGLSFNFI  60
   61 DLYAGFQTFQ ETGKALPDET VKVLKEQCQG ALFGAVQSPT TKVEGYSSPI VALRREMGLF 120
  121 ANVRPVKSVE GEKGKPIDMV IVRENTEDLY IKIEKTYIDK ATGTRVADAT KRISEIATRR 180
  181 IATIALDIAL KRLQTRGQAT LTVTHKSNVL SQSDGLFREI CKEVYESNKD KYGQIKYNEQ 240
  241 IVDSMVYRLF REPQCFDVIV APNLYGDILS DGAAALVGSL GVVPSANVGP EIVIGEPCHG 300
  301 SAPDIAGKGI ANPIATIRST ALMLEFLGHN EAAQDIYKAV DANLREGSIK TPDLGGKAST 360
  361 QQVVDDVLSR L

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 561.9794
Match: 1osjA_
Description: 3-isopropylmalate dehydrogenase, IPMDH
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle