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View Structure Prediction Details

Protein: ICE2
Organism: Saccharomyces cerevisiae
Length: 491 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ICE2.

Description E-value Query
Range
Subject
Range
ICE2_YEAST - Protein ICE2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ICE2 PE=1 SV=1
ICE2 - Integral ER membrane protein with type-III transmembrane domains; mutations cause defects in cortica...
0.0 [1..491] [1..491]
SPAC23C11.01 - ER membrane protein, ICE2 family
YDW1_SCHPO - Uncharacterized protein C23C11.01 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPAC23C1...
0.0 [12..486] [60..422]

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Predicted Domain #1
Region A:
Residues: [1-491]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTSLSKSFMQ SGRICAACFY LLFTLLSIPI SFKVGGLECG LSFTVTLFTL YFITTTLNVL  60
   61 ARRHGGRLYI FFTNCLYYSQ HFIIASLLYL FLSGFSNDEL GNVLKNKYNE SESFLEALKN 120
  121 SLNSNQINYV LYYYYYRFVV QPWQFVLTKS TPFFTLSEGF FTILAIQAVG ETNRWLSNDL 180
  181 NSNTWIISSL LTSGGVITAS LYYLYRIYVT PIWPLSIQTA SLLGLVLSMV CGLGLYGIVS 240
  241 QKGSVIESSL FFAYIVRCIY EISPKLATTA TDEILNLFKD VWQKHQRNLP TADNLLCYFH 300
  301 NVILKNAEVL WGSFIPRGRK KTGDFHDKLI SILSFEKVSL ISKPFWKFFK NFTFSVPLSI 360
  361 NEFCQVTIKM ASESVSPAIV INLCFRVLMF YSATRIIPAL QRKNDKQLRK SRRIMKGLYW 420
  421 YSPCILIAMY THLILQYSGE LKKDLCIWGC SEKWFGVDQP EIIVDSWGFW NWCNIFCTIL 480
  481 VYATELIGSG S

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [359-491]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SINEFCQVTI KMASESVSPA IVINLCFRVL MFYSATRIIP ALQRKNDKQL RKSRRIMKGL  60
   61 YWYSPCILIA MYTHLILQYS GELKKDLCIW GCSEKWFGVD QPEIIVDSWG FWNWCNIFCT 120
  121 ILVYATELIG SGS

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 0.989
Match: 1q3eA
Description: HCN2J 443-645 in the presence of cGMP
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle