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View Structure Prediction Details

Protein: EPS1
Organism: Saccharomyces cerevisiae
Length: 701 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for EPS1.

Description E-value Query
Range
Subject
Range
EPS1 - ER protein with chaperone and co-chaperone activity, involved in retention of resident ER proteins; ...
gi|190406228 - gi|190406228|gb|EDV09495.1| conserved hypothetical protein [Saccharomyces cerevisiae RM11-1a]
EPS1_YEAST - ER-retained PMA1-suppressing protein 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=E...
0.0 [1..701] [1..701]
gi|123993795, gi... - gi|123995343|gb|ABM85273.1| protein disulfide isomerase family A, member 4 [synthetic construct], gi...
PDIA4 - protein disulfide isomerase family A, member 4
1.0E-86 [1..571] [1..635]
PDIA4_MOUSE, PDA... - Protein disulfide-isomerase A4 OS=Mus musculus GN=Pdia4 PE=1 SV=2, (P08003) Protein disulfide-isomer...
1.0E-85 [1..571] [1..628]
PDA4_RAT - (P38659) Protein disulfide-isomerase A4 precursor (EC 5.3.4.1) (Protein ERp-72) (ERp72) (Calcium-bin...
6.0E-84 [1..571] [1..633]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
7.0E-84 [1..571] [1..633]
PDIA1_RABIT - Protein disulfide-isomerase OS=Oryctolagus cuniculus GN=P4HB PE=2 SV=1
3.0E-78 [183..577] [37..477]
PDIA1_BOVIN - Protein disulfide-isomerase OS=Bos taurus GN=P4HB PE=1 SV=1
5.0E-77 [183..574] [38..475]

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Predicted Domain #1
Region A:
Residues: [1-165]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKMNLKRLVV TFFSCITFLL KFTIAAAEPP EGFPEPLNPT NFKEELSKGL HIIDFYSPYC  60
   61 PHCKHLAPVW METWEEFKEE SKTLNITFSQ VNCIESADLC GDENIEYFPE IRLYNPSGYI 120
  121 KSFTETPRTK ESLIAFARRE SMDPNNLDTD LDSAKSESQY LEGFD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 86.274545
Match: 1mek__
Description: Protein disulfide isomerase, PDI
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [166-400]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FLELIAGKAT RPHLVSFWPT KDMKNSDDSL EFKNCDKCHE FQRTWKIISR QLAVDDINTG  60
   61 HVNCESNPTI CEELGFGDLV KITNHRADRE PKVALVLPNK TSNNLFDYPN GYSAKSDGYV 120
  121 DFARRTFTNS KFPNITEGEL EKKANRDIDF LQERGRVTNN DIHLVFSYDP ETVVIEDFDI 180
  181 LEYLIEPLSK IPNIYLHQID KNLINLSRNL FGRMYEKINY DASQTQKVFN KEYFT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 4.30103
Match: 1a8y__
Description: Calsequestrin
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [401-597]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNTVTQLPTF FMFKDGDPIS YVFPGYSTTE MRNIDAIMDW VKKYSNPLVT EVDSSNLKKL  60
   61 ISFQTKSYSD LAIQLISSTD HKHIKGSNKL IKNLLLASWE YEHIRMENNF EEINERRARK 120
  121 ADGIKKIKEK KAPANKIVDK MREEIPHMDQ KKLLLGYLDI SKEKNFFRKY GITGEYKIGD 180
  181 VIIIDKSNNY YYNKDNF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 5.522879
Match: 1jfuA_
Description: Membrane-anchored thioredoxin-like protein TlpA, soluble domain
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [598-701]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GNSLTSNNPQ LLREAFVSLN IPSKALYSSK LKGRLINSPF HNVLSFLDII HGNGMPGYLI  60
   61 VIVLFIAILK GPSIYRRYKV RKHYRAKRNA VGILGNMEKK KNQD

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle