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View Structure Prediction Details

Protein: YSP1
Organism: Saccharomyces cerevisiae
Length: 1228 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YSP1.

Description E-value Query
Range
Subject
Range
YSP1 - Mitochondrial protein with a potential role in promoting mitochondrial fragmentation during programm...
LAM1_YEAST - Membrane-anchored lipid-binding protein LAM1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c...
0.0 [1..1228] [1..1228]
YEE2_SCHPO - Uncharacterized PH domain-containing protein C19A8.02 OS=Schizosaccharomyces pombe (strain 972 / ATC...
SPAC19A8.02 - transcriptional coactivator
0.0 [10..801] [14..804]
gi|6474062 - gi|6474062|dbj|BAA87211.1| Hypothetical protein [Schizosaccharomyces pombe]
2.0E-83 [498..743] [1..235]
gi|12697977 - gi|12697977|dbj|BAB21807.1| KIAA1716 protein [Homo sapiens]
3.0E-70 [25..556] [18..502]
AGD2_ARATH - ADP-ribosylation factor GTPase-activating protein AGD2 OS=Arabidopsis thaliana GN=AGD2 PE=2 SV=1
6.0E-67 [18..457] [6..457]

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Predicted Domain #1
Region A:
Residues: [1-113]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MHEHKAELRL ITVALNEAST DSPSFRASVN YFHTRMESLS SWMHSTVDYV ENTYKPSFQD  60
   61 FQRIKETLFS QLLPSPILLS NGFVSNQPYT PLLVRDFTRD VSDLSNTVMK IIL

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
protein binding 3.17213698546013 bayes_pls_golite062009
binding 2.86147407357315 bayes_pls_golite062009
transcription regulator activity 1.50756932992573 bayes_pls_golite062009
nucleic acid binding 1.2749362891779 bayes_pls_golite062009
DNA binding 1.18878662922624 bayes_pls_golite062009
protein domain specific binding 0.236765394237244 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.198922924806251 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [114-189]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GDENSQYTAA LSALSSDAIN PYFNKRKTFE YYQRKYDSFL TDFLAATNDG NTLIPQNLQN  60
   61 ETFKLVDIKH KYIEAS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 14.0
Match: 1pbv__
Description: Exchange factor ARNO
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.95502209146398 bayes_pls_golite062009
DNA binding 4.49877554292304 bayes_pls_golite062009
nucleic acid binding 4.4138116788102 bayes_pls_golite062009
transcription factor activity 3.78905634607011 bayes_pls_golite062009
transcription activator activity 3.19708783401986 bayes_pls_golite062009
binding 3.09940998297931 bayes_pls_golite062009
sequence-specific DNA binding 3.07549097279613 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.10135825467854 bayes_pls_golite062009
protein binding 1.80415286835431 bayes_pls_golite062009
transcription repressor activity 1.72704408652215 bayes_pls_golite062009
transcription factor binding 0.35726633913804 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 0.18158516638045 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [190-296]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LDLTEAISLM KVNLDKFLIE TIDIVRKNNV ITTKDTKDVI DITPELTETL KDWTDWIESN  60
   61 LQTLQALSSK LSEAKYAILK LSLARMKPSR LIQDYDLKSI QNLKFNL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 14.0
Match: 1pbv__
Description: Exchange factor ARNO
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [297-467]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PKSISNGNNS EEKGLSGWLY MKTTVGHDPK RVVWVRRWCF LQNNVFGVFS LSPSKTYVEE  60
   61 TDKFGILWIT VEYLPKEPRN FCFKLRIQNP NCKTEEENTY IDIILQAESI DELKSWINTL 120
  121 TSHKRIALSI KEENDPRYQL ARKKIEPQFF EFASSSSTST DKLLTSFSSK T

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 18.0
Match: 1eazA_
Description: Tapp1
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [468-571]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LTLVEELKKN YMSEDDIYSI IDNKAYHLRV ISTPIATQLT HLALFSTFLS VSNYYPCATQ  60
   61 ANTWGTANWN DLSYLVNPLK GSSVHKPATV SNSSRFSVSY PDYY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 2.39794
Match: 1dcqA_
Description: Pyk2-associated protein beta; Pyk2-associated protein beta ARF-GAP domain
Matching Structure (courtesy of the PDB):

Predicted Domain #6
Region A:
Residues: [572-1228]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PYSLKVDDIQ FRSIFFSVNH DFLQVPKELV LLRYSSVWCP NNKQKFASMA FVTLNHIYVY  60
   61 LNISGFSYLR RIDLLDIDSI EYDKSPKHVS SRMLHMQRGD GLRFNMSVFF TDRRAVASKL 120
  121 QFLIENKAMH IPKGEKEVLE IFQELDEEIE NEKKIIKDNL SESEHYSKDY DYLLKSTYDH 180
  181 HFENTNETPM ELMSRKLRLE REAWCYFQDN FKVGSKTLFH VLFGDKSQVF PSSLFLCKKG 240
  241 SNLNNNSYWE RIRRAKEDAS CQFELCRKLQ FQLNRTSNFI KDLLWLKDDN DNFKLVLQQR 300
  301 VTKIKQGYYF EVEEGPIIVK FPLCHPLLLR VRFIIAECIT SQGESLKKCD LAILYDFNYV 360
  361 ESIDKLNTKV EKLWLFERIH LNWALRYCKL EHSEINRKTR EYLKKFNDRE KMSDVIKLCG 420
  421 FLGVLPKERI ENDEKAGDFM QPVYINYDFL SLSKIFTKLT VFYLSSVIIK TMKVLLAMVM 480
  481 VIFKCFSKVN KTLYYCLLIS AVTNLFFVGK SIHSYFSVKS AETLFQNYAN GDQRGLQIMH 540
  541 RSLTVPDLNL LTRKMMDNDQ ENPVFKRFDE DKNAYQYKGT RQEIAIKRNQ VLTELKILQN 600
  601 TEKELVQGSY RKFIITERDK CITTQNEIFD LWINDTKLQD YCMACFAEYN RLSAIPV

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle