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View Structure Prediction Details

Protein: TRR2
Organism: Saccharomyces cerevisiae
Length: 342 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TRR2.

Description E-value Query
Range
Subject
Range
gi|190405885 - gi|190405885|gb|EDV09152.1| thioredoxin reductase 2, mitochondrial precursor [Saccharomyces cerevisi...
TRXB2_YEAST - Thioredoxin reductase 2, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=T...
gi|151944052 - gi|151944052|gb|EDN62345.1| thioredoxin reductase [Saccharomyces cerevisiae YJM789]
gi|207344615 - gi|207344615|gb|EDZ71703.1| YHR106Wp-like protein [Saccharomyces cerevisiae AWRI1631]
TRR2 - Mitochondrial thioredoxin reductase involved in protection against oxidative stress, required with G...
0.0 [1..342] [1..342]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
2.0E-99 [9..340] [64..393]
gi|23308231, gi|... - gi|23308231|gb|AAN18085.1| At2g41680/T32G6.20 [Arabidopsis thaliana], gi|15912233|gb|AAL08250.1| At2...
1.0E-98 [9..340] [64..393]
gi|17130082, gi|... - gi|17228232|ref|NP_484780.1| thioredoxin reductase [Nostoc sp. PCC 7120], gi|17130082|dbj|BAB72694.1...
gi|25285003 - pir||AG1898 thioredoxin reductase [imported] - Nostoc sp. (strain PCC 7120)
5.0E-98 [21..338] [28..339]
TRXB_SCHPO - Thioredoxin reductase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=trr1 PE=1 SV=1
trr1 - thioredoxin reductase Trr1
5.0E-98 [24..342] [1..319]
TRXB_CHLPN - Thioredoxin reductase OS=Chlamydia pneumoniae GN=trxB PE=3 SV=1
gi|16752725, gi|... - gi|7189366|gb|AAF38283.1| thioredoxin reductase [Chlamydophila pneumoniae AR39], gi|16752725|ref|NP_...
gi|15835849, gi|... - gi|8978688|dbj|BAA98524.1| thioredoxin reductase [Chlamydophila pneumoniae J138], gi|15835849|ref|NP...
gi|15618234, gi|... - gi|4376591|gb|AAD18463.1| Thioredoxin Reductase [Chlamydophila pneumoniae CWL029], gi|15618234|ref|N...
gi|33236167, gi|... - gi|33241658|ref|NP_876599.1| thioredoxin reductase [Chlamydophila pneumoniae TW-183], gi|33236167|gb...
4.0E-97 [24..338] [1..310]
TRXB_NEUCR - Thioredoxin reductase OS=Neurospora crassa GN=cys-9 PE=3 SV=1
TRXB_NEUCR - Thioredoxin reductase OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /...
9.0E-97 [26..342] [2..318]

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Predicted Domain #1
Region A:
Residues: [1-146]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIKHIVSPFR TNFVGISKSV LSRMIHHKVT IIGSGPAAHT AAIYLARAEM KPTLYEGMMA  60
   61 NGIAAGGQLT TTTDIENFPG FPESLSGSEL MERMRKQSAK FGTNIITETV SKVDLSSKPF 120
  121 RLWTEFNEDA EPVTTDAIIL ATGASA

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [273-342]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HSPATDIVKG QVDEEETGYI KTVPGSSLTS VPGFFAAGDV QDSRYRQAVT SAGSGCIAAL  60
   61 DAERYLSAQE 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1130.0
Match: 1vdc__
Description: Thioredoxin reductase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
thioredoxin-disulfide reductase activity 3.42654162439464 bayes_pls_golite062009
antioxidant activity 3.37477730756688 bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors 3.17769237742078 bayes_pls_golite062009
catalytic activity 1.56773888754354 bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor 1.45104542724719 bayes_pls_golite062009
binding 1.4227698123368 bayes_pls_golite062009
oxidoreductase activity 0.44090433301056 bayes_pls_golite062009
oxygen-dependent protoporphyrinogen oxidase activity 0.1498172520052 bayes_pls_golite062009
dihydrolipoyl dehydrogenase activity 0.130601418359425 bayes_pls_golite062009
protein binding 0.116927178396589 bayes_pls_golite062009
disulfide oxidoreductase activity 0.0160065137614933 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [147-272]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KRMHLPGEET YWQQGISACA VCDGAVPIFR NKPLAVIGGG DSACEEAEFL TKYASKVYIL  60
   61 VRKDHFRASV IMQRRIEKNP NIIVLFNTVA LEAKGDGKLL NMLRIKNTKS NVENDLEVNG 120
  121 LFYAIG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1130.0
Match: 1vdc__
Description: Thioredoxin reductase
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle