YRC Public Data Repository - Protein Structure Prediction

Protein:	KIC1
Organism:	Saccharomyces cerevisiae
Length:	1080 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for KIC1.

Description	E-value	Query Range	Subject Range
KIC1_YEAST - Serine/threonine-protein kinase KIC1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=KIC... KIC1 - Protein kinase of the PAK/Ste20 kinase family, required for cell integrity possibly through regulati...	0.0	[1..1080]	[1..1080]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	0.0	[11..461]	[81..537]
gi\|19171502 - gi\|19171502\|emb\|CAC87494.1\| calcium-dependent protein kinase [Solanum lycopersicum]	0.0	[11..460]	[93..548]
gi\|4336426 - gi\|4336426\|gb\|AAD17800.1\| Ca2+-dependent protein kinase [Mesembryanthemum crystallinum]	0.0	[1..463]	[60..532]
CDPK2_ORYSJ - Calcium-dependent protein kinase isoform 2 OS=Oryza sativa subsp. japonica GN=CPK2 PE=2 SV=2 CDPK2_ORYSA - Calcium-dependent protein kinase, isoform 2 (EC 2.7.11.1) (CDPK 2) - Oryza sativa (Rice)	0.0	[2..461]	[64..529]
gi\|5162882, gi\|5... - gi\|5162882\|dbj\|BAA81751.1\| calcium-dependent protein kinase [Marchantia polymorpha], gi\|5162878\|dbj\|...	0.0	[4..482]	[62..544]
CDPKL_ARATH - Calcium-dependent protein kinase 21 OS=Arabidopsis thaliana GN=CPK21 PE=1 SV=1	0.0	[2..463]	[59..526]

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Predicted Domain #1

Region A:
Residues: [1-101]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTTKPQNSKQ GLAEGEMDVS SLFKRTEVIG RGKFGVVYKG YNVKTGRVYA IKVLNLDSDS  60
   61 DEVEDVQREI QFLASLKQIS NITRYYGSYL KDTSLWIIME H

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	626.9794
Match:	1f3mC_
Description:	pak1
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [102-307]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CAGGSLRSLL RPGKIDEKYI GVIMRELLVA LKCIHKDNVI HRDIKAANVL ITNEGNVKLC  60
   61 DFGVAAQVNQ TSLRRQTMAG TPYWMAPEVI MEGVYYDTKV DIWSLGITTY EIATGNPPYC 120
  121 DVEALRAMQL IIKSKPPRLE DRSYSTSLKE FIALCLDEDP KERLSADDLL KSKFIRAHKA 180
  181 TPTSILKELI SRYLLFRDKN KNKYKI

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	626.9794
Match:	1f3mC_
Description:	pak1
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [308-390]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EGSIPENEPS KPSEAPKPSQ NGGGDEAQKS IASNDNEIKR VNEGDVEMKW DFDSLSSSDY  60
   61 IIENNINLDA LAEDNNEWAT AQH

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	20.154902
Match:	1cdmA_
Description:	Calmodulin
Matching Structure (courtesy of the PDB):

Predicted Domain #4

Region A:
Residues: [391-470]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DLFNYAYPDE DSYYFDPTSH NTRPFVYQGT TIGKGYPGTI AQNSTLNAPV TNNYTNSKYP  60
   61 SKMVAGTTNT SGTHTAGPMT

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	20.154902
Match:	1cdmA_
Description:	Calmodulin
Matching Structure (courtesy of the PDB):

Predicted Domain #5

Region A:
Residues: [471-665]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSKRLESKAP KQLLELFEDN EIITAENDVN TEAPKISKSI SSLNAGNSSR DDFIPSISNE  60
   61 VNGNINNNKM RPHLPPLSSG NNYYSQSTPA LPLLQTKFNK TSKGPPTSGL TTAPTSIEIE 120
  121 IPEELPNSAL PTPASADPVL IPSTKARSST VTAGTPSSSS SIQYKSPSNV PRRLTVSNNR 180
  181 PEHCPSTITN QKLGS

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	11.62
Match:	1ei3A
Description:	Fibrinogen
Matching Structure (courtesy of the PDB):

Predicted Domain #6

Region A:
Residues: [666-671]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AVASNS

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [896-972]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GKIKRSQSIS NRKNSSASEH PLNILGSSVS GNVSGIGNNN VGSNNNSGPN NSVPLSANTG  60
   61 NTTIKANSTT IATSSSA

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	10.44
Match:	1l8mA
Description:	No description for 1l8mA was found.

Predicted Domain #7

Region A:
Residues: [672-744]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GISSTPNNSN NYNNNTDSEN SRGSSGSNTA NSTQMGITNP GNVTKLSTHK ASSPSRPLFG  60
   61 VGTSPNRKPA GSP

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	10.44
Match:	1l8mA
Description:	No description for 1l8mA was found.

Predicted Domain #8

Region A:
Residues: [745-823]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TQNIGHNSTH TNLAPPPTMK PMANSKDNKD ILLQPLNSIP SSSTLNTISG NSSNNLTSSN  60
   61 YFSNEKEGSR VNGDFKRNN

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	10.44
Match:	1l8mA
Description:	No description for 1l8mA was found.

Predicted Domain #9

Region A:
Residues: [824-895]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PNLKLQMPLP TPVVRNKLLD PNTATSQNNN GMPGSAGIST NENINQFGFN TSSASNIPVS  60
   61 MTPISEKHID FG

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	10.44
Match:	1l8mA
Description:	No description for 1l8mA was found.

Predicted Domain #10

Region A:
Residues: [973-1080]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AASTTAPISQ QTIPSGTQFN HILSSAATAA NSVNSLGFGM CPPPQSLQME MFLDLESFLP  60
   61 GKQRRVDRKP QVLKELENLL QMFEEGLPCI EHALKEQLIS TPIKDNEH

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits