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View Structure Prediction Details

Protein: DED81
Organism: Saccharomyces cerevisiae
Length: 554 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for DED81.

Description E-value Query
Range
Subject
Range
gi|190405803 - gi|190405803|gb|EDV09070.1| asparaginyl-tRNA synthetase [Saccharomyces cerevisiae RM11-1a]
DED81 - Cytosolic asparaginyl-tRNA synthetase, required for protein synthesis, catalyzes the specific attach...
SYNC_YEAST - Asparagine--tRNA ligase, cytoplasmic OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=DED...
gi|151943961 - gi|151943961|gb|EDN62254.1| asparaginyl-tRNA synthetase [Saccharomyces cerevisiae YJM789]
0.0 [1..554] [1..554]
NARS - asparaginyl-tRNA synthetase
0.0 [1..554] [3..548]
gi|220953642, gi... - gi|220953642|gb|ACL89364.1| Aats-asn-PA [synthetic construct], gi|220943736|gb|ACL84411.1| Aats-asn-...
Aats-asn-PA, FBp... - The gene Asparaginyl-tRNA synthetase is referred to in FlyBase by the symbol Dmel\Aats-asn (CG10687,...
0.0 [1..554] [11..558]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [3..554] [2..548]
SYNC_BRUMA - Asparagine--tRNA ligase, cytoplasmic OS=Brugia malayi PE=1 SV=1
0.0 [3..554] [2..548]
SYNC_SCHPO - Probable asparagine--tRNA ligase, cytoplasmic OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843)...
SPBC1773.10c - asparagine-tRNA ligase Ded81
0.0 [5..554] [20..568]
gi|221321410 - gi|221321410|ref|ZP_03602704.1| lysyl-tRNA synthetase [Bacillus subtilis subsp. subtilis str. SMY]
gi|221317147 - gi|221317147|ref|ZP_03598441.1| lysyl-tRNA synthetase [Bacillus subtilis subsp. subtilis str. JH642]
gi|221312214 - gi|221312214|ref|ZP_03594019.1| lysyl-tRNA synthetase [Bacillus subtilis subsp. subtilis str. NCIB 3...
SYK_BACSU - Lysine--tRNA ligase OS=Bacillus subtilis (strain 168) GN=lysS PE=3 SV=1
SYK_BACSU - Lysine--tRNA ligase OS=Bacillus subtilis GN=lysS PE=3 SV=1
0.0 [78..551] [8..499]
gi|126943674, gi... - gi|254899407|ref|ZP_05259331.1| asparaginyl-tRNA synthetase [Listeria monocytogenes J0161], gi|15318...
gi|254831503, gi... - gi|254831503|ref|ZP_05236158.1| asparaginyl-tRNA synthetase [Listeria monocytogenes 10403S], gi|1531...
SYN_LISMO - Asparagine--tRNA ligase OS=Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e) GN=asnS...
gi|254912454, gi... - gi|254912454|ref|ZP_05262466.1| asparaginyl-tRNA synthetase [Listeria monocytogenes J2818], gi|15319...
gi|284802341|ref... - asparaginyl-tRNA synthetase [Listeria monocytogenes 08-5578]
gi|153175124, gi... - gi|254827219|ref|ZP_05231906.1| asparaginyl-tRNA synthetase [Listeria monocytogenes FSL N3-165], gi|...
gi|153179957, gi... - gi|254936781|ref|ZP_05268478.1| asparaginyl-tRNA synthetase [Listeria monocytogenes F6900], gi|15317...
gi|47096479, gi|... - gi|47096479|ref|ZP_00234071.1| asparaginyl-tRNA synthetase [Listeria monocytogenes str. 1/2a F6854],...
gi|224500248 - gi|224500248|ref|ZP_03668597.1| asparaginyl-tRNA synthetase [Listeria monocytogenes Finland 1988]
gi|284995483|ref... - asparaginyl-tRNA synthetase [Listeria monocytogenes 08-5923]
SYN_LISMO - Asparagine--tRNA ligase OS=Listeria monocytogenes GN=asnS PE=3 SV=1
gi|224501304 - gi|224501304|ref|ZP_03669611.1| asparaginyl-tRNA synthetase [Listeria monocytogenes FSL R2-561]
0.0 [117..554] [1..430]
SYN_LISIN - Asparagine--tRNA ligase OS=Listeria innocua serovar 6a (strain CLIP 11262) GN=asnS PE=3 SV=1
SYN_LISIN - Asparagine--tRNA ligase OS=Listeria innocua GN=asnS PE=3 SV=1
0.0 [117..554] [1..430]

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Predicted Domain #1
Region A:
Residues: [1-104]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSLYIKEAT GVDELTTAGS QDHPFKTPAY ALFASQQKSD ATEPKLFVFK TEDNEYQEIS  60
   61 ASALKKARKG CDGLKKKAVK QKEQELKKQQ KEAENAAKQL SALN

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.577 f.32.1 a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)
View Download 0.624 a.24.7 FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)
View Download 0.541 d.52.7 Ribosome-binding factor A, RbfA
View Download 0.631 a.29.4 RecG, N-terminal domain
View Download 0.517 a.78.1 Fatty acid responsive transcription factor FadR, C-terminal domain
View Download 0.504 i.11.1 Computational models partly based on NMR data
View Download 0.484 a.24.3 Cytochromes
View Download 0.476 f.1.4 Bcl-2 inhibitors of programmed cell death
View Download 0.450 a.24.3 Cytochromes
View Download 0.446 a.24.7 FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)
View Download 0.436 f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.424 a.40.1 Calponin-homology domain, CH-domain
View Download 0.412 a.40.1 Calponin-homology domain, CH-domain
View Download 0.405 c.59.1 MurD-like peptide ligases, peptide-binding domain
View Download 0.402 c.13.2 Anti-sigma factor antagonist SpoIIaa
View Download 0.384 f.1.4 Bcl-2 inhibitors of programmed cell death
View Download 0.377 a.24.10 Histidine-containing phosphotransfer domain, HPT domain
View Download 0.373 d.57.1 DNA damage-inducible protein DinI
View Download 0.371 a.7.7 BAG domain
View Download 0.351 a.13.1 alpha-2-Macroglobulin receptor associated protein (RAP) domain 1
View Download 0.346 d.109.1 Actin depolymerizing proteins
View Download 0.336 a.1.1 Globin-like
View Download 0.336 a.23.1 HSC20 (HSCB), C-terminal oligomerisation domain
View Download 0.332 a.7.8 GAT domain
View Download 0.329 a.47.2 t-snare proteins
View Download 0.317 a.46.1 Methionine synthase domain
View Download 0.307 f.1.4 Bcl-2 inhibitors of programmed cell death
View Download 0.303 a.12.1 Kix domain of CBP (creb binding protein)
View Download 0.302 a.29.4 RecG, N-terminal domain
View Download 0.300 a.24.11 Bacterial GAP domain
View Download 0.298 a.62.1 Hepatitis B viral capsid (hbcag)
View Download 0.298 a.24.3 Cytochromes
View Download 0.290 a.71.2 Helical domain of Sec23/24
View Download 0.286 a.130.1 Chorismate mutase II
View Download 0.276 d.68.1 Translation initiation factor IF3, C-terminal domain
View Download 0.276 d.68.3 SirA-like
View Download 0.273 a.47.2 t-snare proteins
View Download 0.266 c.59.1 MurD-like peptide ligases, peptide-binding domain
View Download 0.266 c.84.1 Phosphoglucomutase, first 3 domains
View Download 0.261 a.2.3 Chaperone J-domain
View Download 0.260 d.79.2 Tubulin/Dihydroxyacetone kinase C-terminal domain
View Download 0.257 a.133.1 Phospholipase A2, PLA2
View Download 0.251 a.29.3 Acyl-CoA dehydrogenase C-terminal domain-like
View Download 0.244 c.8.7 RraA-like
View Download 0.239 a.8.2 Plasmid maintenance system epsilon/zeta, antidote epsilon subunit
View Download 0.233 i.11.1 Computational models partly based on NMR data
View Download 0.225 c.55.4 Translational machinery components
View Download 0.222 f.32.1 a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)
View Download 0.214 b.82.4 Regulatory protein AraC
View Download 0.212 d.43.1 Elongation factor Ts (EF-Ts), dimerisation domain
View Download 0.210 a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.208 a.60.10 Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain
View Download 0.206 a.8.1 Bacterial immunoglobulin/albumin-binding domains
View Download 0.206 a.7.4 Smac/diablo
View Download 0.205 a.48.1 N-terminal domain of cbl (N-cbl)

Predicted Domain #2
Region A:
Residues: [105-226]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ITIKEDESLP AAIKTRIYDS YSKVGQRVKV SGWIHRLRSN KKVIFVVLRD GSGFIQCVLS  60
   61 GDLALAQQTL DLTLESTVTL YGTIVKLPEG KTAPGGVELN VDYYEVVGLA PGGEDSFTNK 120
  121 IA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 611.9897
Match: 1b8aA_
Description: Aspartyl-tRNA synthetase (AspRS)
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [227-554]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EGSDPSLLLD QRHLALRGDA LSAVMKVRAA LLKSVRRVYD EEHLTEVTPP CMVQTQVEGG  60
   61 STLFKMNYYG EEAYLTQSSQ LYLETCLASL GDVYTIQESF RAEKSHTRRH LSEYTHIEAE 120
  121 LAFLTFDDLL QHIETLIVKS VQYVLEDPIA GPLVKQLNPN FKAPKAPFMR LQYKDAITWL 180
  181 NEHDIKNEEG EDFKFGDDIA EAAERKMTDT IGVPIFLTRF PVEIKSFYMK RCSDDPRVTE 240
  241 SVDVLMPNVG EITGGSMRID DMDELMAGFK REGIDTDAYY WFIDQRKYGT CPHGGYGIGT 300
  301 ERILAWLCDR FTVRDCSLYP RFSGRCKP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 611.9897
Match: 1b8aA_
Description: Aspartyl-tRNA synthetase (AspRS)
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle