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View Structure Prediction Details

Protein: SPO11
Organism: Saccharomyces cerevisiae
Length: 398 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SPO11.

Description E-value Query
Range
Subject
Range
SPO11 - Meiosis-specific protein that initiates meiotic recombination by catalyzing the formation of double-...
gi|151944178 - gi|151944178|gb|EDN62470.1| endodeoxyribonuclease [Saccharomyces cerevisiae YJM789]
SPO11_YEAST - Meiosis-specific protein SPO11 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SPO11 PE=...
0.0 [1..398] [1..398]
SPO11 - SPO11 meiotic protein covalently bound to DSB homolog (S. cerevisiae)
0.0 [35..390] [36..373]
gi|162318682 - gi|162318682|gb|AAI56814.1| Sporulation protein, meiosis-specific, SPO11 homolog (S. cerevisiae) [sy...
SPO11_MOUSE - Meiotic recombination protein SPO11 OS=Mus musculus GN=Spo11 PE=1 SV=2
0.0 [41..397] [43..380]
SPO11_ARATH - Meiotic recombination protein SPO11-1 OS=Arabidopsis thaliana GN=SPO11-1 PE=1 SV=1
2.0E-99 [42..397] [10..345]

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Predicted Domain #1
Region A:
Residues: [1-95]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MALEGLRKKY KTRQELVKAL TPKRRSIHLN SNGHSNGTPC SNADVLAHIK HFLSLAANSL  60
   61 EQHQQPISIV FQNKKKKGDT SSPDIHTTLD FPLNG

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.356 0.285 endodeoxyribonuclease activity, producing 3'-phosphomonoesters d.58.7 RNA-binding domain, RBD
View Download 0.347 0.040 endodeoxyribonuclease activity, producing 3'-phosphomonoesters d.13.1 HIT-like
View Download 0.399 0.023 endodeoxyribonuclease activity, producing 3'-phosphomonoesters d.150.1 4'-phosphopantetheinyl transferase
View Download 0.569 0.022 endodeoxyribonuclease activity, producing 3'-phosphomonoesters d.58.48 MTH1187-like
View Download 0.345 N/A N/A d.58.16 Poly(A) polymerase, C-terminal domain
View Download 0.338 N/A N/A d.109.1 Actin depolymerizing proteins
View Download 0.337 N/A N/A d.58.20 NAD-binding domain of HMG-CoA reductase
View Download 0.334 N/A N/A f.16.1 Gated mechanosensitive channel
View Download 0.318 N/A N/A d.52.3 Prokaryotic type KH domain (KH-domain type II)
View Download 0.300 N/A N/A a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.271 N/A N/A d.13.1 HIT-like
View Download 0.269 N/A N/A a.12.1 Kix domain of CBP (creb binding protein)
View Download 0.261 N/A N/A c.84.1 Phosphoglucomutase, first 3 domains
View Download 0.261 N/A N/A c.95.1 Thiolase-like
View Download 0.259 N/A N/A d.68.1 Translation initiation factor IF3, C-terminal domain
View Download 0.253 N/A N/A c.16.1 Lumazine synthase
View Download 0.248 N/A N/A d.79.3 L30e-like
View Download 0.237 N/A N/A d.58.7 RNA-binding domain, RBD
View Download 0.228 N/A N/A d.58.5 GlnB-like
View Download 0.223 N/A N/A a.151.1 Glutamyl tRNA-reductase dimerization domain
View Download 0.219 N/A N/A d.16.1 FAD-linked reductases, C-terminal domain
View Download 0.218 N/A N/A d.58.21 Molybdenum cofactor biosynthesis protein C, MoaC
View Download 0.214 N/A N/A a.28.1 ACP-like
View Download 0.210 N/A N/A c.37.1 P-loop containing nucleoside triphosphate hydrolases
View Download 0.205 N/A N/A d.15.6 Superantigen toxins, C-terminal domain
View Download 0.204 N/A N/A d.52.7 Ribosome-binding factor A, RbfA
View Download 0.202 N/A N/A d.15.1 Ubiquitin-like

Predicted Domain #2
Region A:
Residues: [96-170]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PHLCTHQFKL KRCAILLNLL KVVMEKLPLG KNTTVRDIFY SNVELFQRQA NVVQWLDVIR  60
   61 FNFKLSPRKS LNIIP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 72.522879
Match: 1d3yA_
Description: DNA topoisomerase IV, alpha subunit
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [171-285]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AQKGLVYSPF PIDIYDNILT CENEPKMQKQ TIFPGKPCLI PFFQDDAVIK LGTTSMCNIV  60
   61 IVEKEAVFTK LVNNYHKLST NTMLITGKGF PDFLTRLFLK KLEQYCSKLI SDCSI

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [298-319]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LNYTHSNERN AYICTMANYK GI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 72.522879
Match: 1d3yA_
Description: DNA topoisomerase IV, alpha subunit
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [286-297]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FTDADPYGIS IA

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [320-398]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RITQVLAQNN EVHNKSIQLL SLNQRDYSLA KNLIASLTAN SWDIATSPLK NVIIECQREI  60
   61 FFQKKAEMNE IDARIFEYK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 72.522879
Match: 1d3yA_
Description: DNA topoisomerase IV, alpha subunit
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle