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View Structure Prediction Details

Protein: SAY1
Organism: Saccharomyces cerevisiae
Length: 424 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SAY1.

Description E-value Query
Range
Subject
Range
SAY1_YEAST - Steryl acetyl hydrolase 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SAY1 PE=1 SV=1
SAY1 - Sterol deacetylase; component of the sterol acetylation/deacetylation cycle along with Atf2p; integr...
gi|190406733 - gi|190406733|gb|EDV10000.1| conserved hypothetical protein [Saccharomyces cerevisiae RM11-1a]
0.0 [1..424] [1..424]
CES1D_RAT - Carboxylesterase 1D OS=Rattus norvegicus GN=Ces1d PE=1 SV=2
gi|57554 - gi|57554|emb|CAA46391.1| carboxylesterase [Rattus rattus]
3.0E-68 [55..353] [9..322]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
4.0E-68 [55..353] [9..322]
CES1D_MOUSE - Carboxylesterase 1D OS=Mus musculus GN=Ces1d PE=1 SV=1
8.0E-68 [55..353] [9..322]
CES1D_RAT - Carboxylesterase 1D OS=Rattus norvegicus GN=Ces1d PE=1 SV=2
gi|57554 - gi|57554|emb|CAA46391.1| carboxylesterase [Rattus rattus]
1.0E-67 [55..353] [9..322]

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Predicted Domain #1
Region A:
Residues: [1-424]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAANSGLDSK VEYYRLQENE IISAVSSEDA DQNDAGFRLS TIHLHLFHGL KFAALLFTVV  60
   61 PVFIILDSMK IIFQRKRRFC LDHVNRSFLR QSSWILDERI CQYVLNPLFV CLYPSTFSSP 120
  121 TYVKCNIPIE DQKSPENNIF QDHQLNAPKI VSTKFYQYVM PEGFDPTTDP VLVFYHGGGY 180
  181 ALKLTPTSFS FLNNMRNAFP KMAILVPDYT VTATDDQSKK YPLQILQNVA IFDYVVKTMG 240
  241 CKNVVIMGDS AGGNAVLNIV LYLRKCHREI YPKKVIAISP WANATFFHEG EKEYMQGTQE 300
  301 WDGLCLKSHS MFGRMFVGNN PNVDFTSDPF VNIEKNFETK MWQDILKKCS VMITYGSDEL 360
  361 LSFQNKILAK KMSDASEGCN HFTAKNVLVE HQGYHTGPIL NYSRNMDRWT NIPSIARILE 420
  421 FMQS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 63.0
Match: 1k4yA_
Description: Mammalian carboxylesterase (liver carboxylesterase I)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
catalytic activity 1.39629727416851 bayes_pls_golite062009
sterol esterase activity 1.21262745914703 bayes_pls_golite062009
lipase activity 0.849473630399459 bayes_pls_golite062009
carboxylesterase activity 0.424330502936163 bayes_pls_golite062009
hydrolase activity, acting on ester bonds 0.264183693934251 bayes_pls_golite062009
hydrolase activity 0.0199633894876208 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle