YRC Public Data Repository - Protein Structure Prediction

Protein:	GND2
Organism:	Saccharomyces cerevisiae
Length:	492 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for GND2.

Description	E-value	Query Range	Subject Range
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	0.0	[1..492]	[1..483]
GND2 - 6-phosphogluconate dehydrogenase (decarboxylating), catalyzes an NADPH regenerating reaction in the ... 6PGD2_YEAST - 6-phosphogluconate dehydrogenase, decarboxylating 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 ...	0.0	[1..492]	[1..492]
6PGD_AGGAC - 6-phosphogluconate dehydrogenase, decarboxylating OS=Aggregatibacter actinomycetemcomitans GN=gnd PE...	0.0	[5..491]	[4..483]
gi\|221323828 - gi\|221323828\|ref\|ZP_03605122.1\| 6-phosphogluconate dehydrogenase [Bacillus subtilis subsp. subtilis ... 6PGD_BACSU - 6-phosphogluconate dehydrogenase, NADP(+)-dependent, decarboxylating OS=Bacillus subtilis (strain 16... gi\|221319552 - gi\|221319552\|ref\|ZP_03600846.1\| 6-phosphogluconate dehydrogenase [Bacillus subtilis subsp. subtilis ... gi\|221314629 - gi\|221314629\|ref\|ZP_03596434.1\| 6-phosphogluconate dehydrogenase [Bacillus subtilis subsp. subtilis ... 6PGD2_BACSU - 6-phosphogluconate dehydrogenase, decarboxylating 2 OS=Bacillus subtilis GN=yqjI PE=1 SV=4	0.0	[4..470]	[2..467]
gi\|121586434, gi... - gi\|121586434\|ref\|ZP_01676222.1\| 6-phosphogluconate dehydrogenase, decarboxylating [Vibrio cholerae 2... gi\|153222817, gi... - gi\|153222817\|ref\|ZP_01953461.1\| 6-phosphogluconate dehydrogenase, decarboxylating [Vibrio cholerae M... gi\|124120824, gi... - gi\|153803642\|ref\|ZP_01958228.1\| 6-phosphogluconate dehydrogenase, decarboxylating [Vibrio cholerae M... gi\|153819213, gi... - gi\|153819213\|ref\|ZP_01971880.1\| 6-phosphogluconate dehydrogenase, decarboxylating [Vibrio cholerae N... gi\|227011606, gi... - gi\|227812464\|ref\|YP_002812474.1\| 6-phosphogluconate dehydrogenase, decarboxylating [Vibrio cholerae ... gi\|229510189, gi... - gi\|229510189\|ref\|ZP_04399669.1\| 6-phosphogluconate dehydrogenase decarboxylating [Vibrio cholerae B3... gi\|229505957, gi... - gi\|229505957\|ref\|ZP_04395466.1\| 6-phosphogluconate dehydrogenase decarboxylating [Vibrio cholerae BX... gi\|229517682, gi... - gi\|229517682\|ref\|ZP_04407127.1\| 6-phosphogluconate dehydrogenase decarboxylating [Vibrio cholerae RC... gi\|229605489, gi... - gi\|229605489\|ref\|YP_002876193.1\| 6-phosphogluconate dehydrogenase decarboxylating [Vibrio cholerae M... gi\|15601652, gi\|... - gi\|9658332\|gb\|AAF96795.1\| 6-phosphogluconate dehydrogenase, decarboxylating [Vibrio cholerae O1 biov... gi\|11251350 - pir\|\|C82404 6-phosphogluconate dehydrogenase, decarboxylating VCA0898 [imported] - Vibrio cholerae (... gi\|254845768, gi... - gi\|75831146\|ref\|ZP_00760413.1\| COG0362: 6-phosphogluconate dehydrogenase [Vibrio cholerae MO10], gi\|... gi\|75821071, gi\|... - gi\|75821071\|ref\|ZP_00751107.1\| COG0362: 6-phosphogluconate dehydrogenase [Vibrio cholerae V51], gi\|2... gi\|150425313, gi... - gi\|254284528\|ref\|ZP_04959495.1\| 6-phosphogluconate dehydrogenase, decarboxylating [Vibrio cholerae A... gi\|121726501, gi... - gi\|75815961\|ref\|ZP_00746447.1\| COG0362: 6-phosphogluconate dehydrogenase [Vibrio cholerae V52], gi\|1...	0.0	[4..491]	[1..481]
gi\|12721945, gi\|... - gi\|15603419\|ref\|NP_246493.1\| 6-phosphogluconate dehydrogenase [Pasteurella multocida subsp. multocid...	0.0	[5..491]	[4..483]
gi\|11251370 - pir\|\|E81248 6-phosphogluconate dehydrogenase, decarboxylating NMB0015 [imported] - Neisseria meningi... gi\|15675963, gi\|... - gi\|7225240\|gb\|AAF40494.1\| 6-phosphogluconate dehydrogenase, decarboxylating [Neisseria meningitidis ...	0.0	[4..491]	[1..481]
gi\|7379024, gi\|1... - gi\|7379024\|emb\|CAB83570.1\| 6-phosphogluconate dehydrogenase, decarboxylating [Neisseria meningitidis... gi\|11251368 - pir\|\|B82021 phosphogluconate dehydrogenase (decarboxylating) (EC 1.1.1.44) NMA0262 [imported] - Neis...	0.0	[4..491]	[1..481]
EG10411 - 6-phosphogluconate dehydrogenase, decarboxylating / 6-phosphogluconate dehydrogenase, decarboxylatin... gi\|238861312, gi... - gi\|238901220\|ref\|YP_002927016.1\| gluconate-6-phosphate dehydrogenase, decarboxylating [Escherichia c... gi\|170081660, gi... - gi\|170081660\|ref\|YP_001730980.1\| gluconate-6-phosphate dehydrogenase, decarboxylating [Escherichia c... gi\|1736717, gi\|8... - gi\|89108850\|ref\|AP_002630.1\| gluconate-6-phosphate dehydrogenase, decarboxylating [Escherichia coli ... EG10411 - 6-phosphogluconate dehydrogenase, decarboxylating / 6-phosphogluconate dehydrogenase, decarboxylatin... 6PGD_ECOLI - 6-phosphogluconate dehydrogenase, decarboxylating (EC 1.1.1.44) - Escherichia coli	0.0	[4..470]	[2..466]

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Predicted Domain #1

Region A:
Residues: [1-182]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSKAVGDLGL VGLAVMGQNL ILNAADHGFT VVAYNRTQSK VDRFLANEAK GKSIIGATSI  60
   61 EDLVAKLKKP RKIMLLIKAG APVDTLIKEL VPHLDKGDII IDGGNSHFPD TNRRYEELTK 120
  121 QGILFVGSGV SGGEDGARFG PSLMPGGSAE AWPHIKNIFQ SIAAKSNGEP CCEWVGPAGS 180
  181 GH

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1936.0
Match:	1pgn__
Description:	6-phosphogluconate dehydrogenase (6PGD); 6-phosphogluconate dehydrogenase
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [183-492]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YVKMVHNGIE YGDMQLICEA YDIMKRIGRF TDKEISEVFD KWNTGVLDSF LIEITRDILK  60
   61 FDDVDGKPLV EKIMDTAGQK GTGKWTAINA LDLGMPVTLI GEAVFARCLS AIKDERKRAS 120
  121 KLLAGPTVPK DAIHDREQFV YDLEQALYAS KIISYAQGFM LIREAARSYG WKLNNPAIAL 180
  181 MWRGGCIIRS VFLAEITKAY RDDPDLENLL FNEFFASAVT KAQSGWRRTI ALAATYGIPT 240
  241 PAFSTALAFY DGYRSERLPA NLLQAQRDYF GAHTFRILPE CASAHLPVDK DIHINWTGHG 300
  301 GNISSSTYQA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1936.0
Match:	1pgn__
Description:	6-phosphogluconate dehydrogenase (6PGD); 6-phosphogluconate dehydrogenase
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits