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View Structure Prediction Details

Protein: LSC2
Organism: Saccharomyces cerevisiae
Length: 427 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for LSC2.

Description E-value Query
Range
Subject
Range
SUCLA2 - succinate-CoA ligase, ADP-forming, beta subunit
0.0 [14..426] [36..445]
SUCB1_PIG - Succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial (Fragment) OS=Sus scrofa GN=SUCLA2 PE=...
0.0 [19..426] [3..407]
LSC2 - Beta subunit of succinyl-CoA ligase, which is a mitochondrial enzyme of the TCA cycle that catalyzes...
SUCB_YEAST - Succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial OS=Saccharomyces cerevisiae (strain AT...
gi|151943518 - gi|151943518|gb|EDN61829.1| ligase of succinyl-coa [Saccharomyces cerevisiae YJM789]
0.0 [1..427] [1..427]
gi|148703905, gi... - gi|3766201|gb|AAC64398.1| ATP-specific succinyl-CoA synthetase beta subunit [Mus musculus], gi|14870...
0.0 [18..426] [3..408]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [12..423] [3..412]
SUCB1_COLLI - Succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial (Fragment) OS=Columba livia GN=SUCLA2 ...
0.0 [29..426] [1..395]

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Predicted Domain #1
Region A:
Residues: [1-50]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYSRKSLSLI SKCGQLSRLN AQAALQARRH LSIHEYRSAQ LLREYGIGTP 

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [139-278]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VDTKHEAYLS ILMDRQTKKP MIIASSQGGM NIEEVAERTP DAIKKFSIET SKGLSPQMAK  60
   61 DVAKSLGFSP DAQDEAAKAV SNLYKIFMER DATQVEINPL SEIEHDPTHK IMCTDAKFGF 120
  121 DDNASFRQEK IYSWRDLSQE 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1084.9691
Match: 1eucB_
Description: Succinyl-CoA synthetase, beta-chain, C-terminal domain; Succinyl-CoA synthetase, beta-chain, N-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
succinate-CoA ligase (GDP-forming) activity 9.38156037766008 bayes_pls_golite062009
succinate-CoA ligase activity 9.37213380498009 bayes_pls_golite062009
CoA-ligase activity 8.19630272128785 bayes_pls_golite062009
acid-thiol ligase activity 7.98453115335343 bayes_pls_golite062009
succinate-CoA ligase (ADP-forming) activity 7.27105019329796 bayes_pls_golite062009
ligase activity, forming carbon-sulfur bonds 7.23103788464777 bayes_pls_golite062009
ligase activity 3.25077459445999 bayes_pls_golite062009
ATP citrate synthase activity 3.09252003125984 bayes_pls_golite062009
transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer 3.07329302783164 bayes_pls_golite062009
catalytic activity 2.5009559386228 bayes_pls_golite062009
CoA carboxylase activity 1.75094739650292 bayes_pls_golite062009
ligase activity, forming carbon-carbon bonds 1.59015373957506 bayes_pls_golite062009
acetyl-CoA carboxylase activity 1.29064883699349 bayes_pls_golite062009
transferase activity, transferring acyl groups 1.15639517822408 bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds 0.992008268375695 bayes_pls_golite062009
binding 0.346654244533873 bayes_pls_golite062009
biotin carboxylase activity 0.0172732430077291 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [51-138]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EGFPAFTPEE AFEAAKKLNT NKLVIKAQAL TGGRGKGHFD TGYKSGVHMI ESPQQAEDVA  60
   61 KEMLNHNLIT KQTGIAGKPV SAVYIVKR

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [279-427]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DPDEVKAKKY DLNFVKLKGN IGCLVNGAGL AMATMDVIKL NGGDPANFLD CGGGATPETI  60
   61 KQGFELILSN KNVDAIFVNI FGGIVRCDYV ALGLVEAARE LEVRVPIVAR LQGTKVEEGR 120
  121 DIINKSGVKI YSFDELDPAA KKVVELTQN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1084.9691
Match: 1eucB_
Description: Succinyl-CoA synthetase, beta-chain, C-terminal domain; Succinyl-CoA synthetase, beta-chain, N-terminal domain
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
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