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View Structure Prediction Details

Protein: PDX1
Organism: Saccharomyces cerevisiae
Length: 410 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PDX1.

Description E-value Query
Range
Subject
Range
ODP23_ARATH - Dihydrolipoyllysine-residue acetyltransferase component 3 of pyruvate dehydrogenase complex, mitocho...
6.0E-87 [18..400] [97..454]
gi|162458262, gi... - gi|5669871|gb|AAD46491.1|AF135014_1 dihydrolipoamide S-acetyltransferase [Zea mays], gi|162458262|re...
9.0E-87 [3..400] [87..457]
DLAT - dihydrolipoamide S-acetyltransferase
1.0E-75 [4..400] [157..530]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
1.0E-75 [4..400] [158..531]
gi|447739 - gi|447739|prf||1915304A nylB upstream ORF
2.0E-75 [4..400] [158..531]

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Predicted Domain #1
Region A:
Residues: [1-147]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLSAISKVST LKSCTRYLTK CNYHASAKLL AVKTFSMPAM SPTMEKGGIV SWKYKVGEPF  60
   61 SAGDVILEVE TDKSQIDVEA LDDGKLAKIL KDEGSKDVDV GEPIAYIADV DDDLATIKLP 120
  121 QEANTANAKS IEIKKPSADS TEATQQH

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 163.522879
Match: 1fyc__
Description: Ipoyl domain of dihydrolipoamide acetyltransferase
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [148-218]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LKKATVTPIK TVDGSQANLE QTLLPSVSLL LAENNISKQK ALKEIAPSGS NGRLLKGDVL  60
   61 AYLGKIPQDS V

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 4.045757
Match: 1bal__
Description: E3-binding domain of dihydrolipoamide succinyltransferase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
dihydrolipoyllysine-residue acetyltransferase activity 9.65061123545754 bayes_pls_golite062009
dihydrolipoamide S-acyltransferase activity 9.64995677986911 bayes_pls_golite062009
S-acetyltransferase activity 9.49696044977584 bayes_pls_golite062009
S-acyltransferase activity 8.45313874919036 bayes_pls_golite062009
pyruvate dehydrogenase activity 8.17557182322815 bayes_pls_golite062009
pyruvate dehydrogenase (acetyl-transferring) activity 6.40483178382327 bayes_pls_golite062009
acetyltransferase activity 6.08159176722072 bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor 5.93985773477717 bayes_pls_golite062009
transferase activity, transferring acyl groups other than amino-acyl groups 5.74314131636952 bayes_pls_golite062009
acyltransferase activity 5.72047003788767 bayes_pls_golite062009
transferase activity, transferring acyl groups 4.60481199262496 bayes_pls_golite062009
S-succinyltransferase activity 4.10308166636667 bayes_pls_golite062009
dihydrolipoyllysine-residue succinyltransferase activity 4.10308166636667 bayes_pls_golite062009
carnitine O-acyltransferase activity 2.87366177129153 bayes_pls_golite062009
succinyltransferase activity 2.08404693277798 bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors 1.78431187655869 bayes_pls_golite062009
catalytic activity 1.51562638409295 bayes_pls_golite062009
O-acyltransferase activity 1.33852311685118 bayes_pls_golite062009
O-palmitoyltransferase activity 1.22729402619659 bayes_pls_golite062009
carnitine O-palmitoyltransferase activity 1.22729402619659 bayes_pls_golite062009
transferase activity 1.08341671157927 bayes_pls_golite062009
carnitine O-acetyltransferase activity 1.00868366840715 bayes_pls_golite062009
O-acetyltransferase activity 0.1424856707148 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [219-410]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NKVTEFIKKN ERLDLSNIKP IQLKPKIAEQ AQTKAADKPK ITPVEFEEQL VFHAPASIPF  60
   61 DKLSESLNSF MKEAYQFSHG TPLMDTNSKY FDPIFEDLVT LSPREPRFKF SYDLMQIPKA 120
  121 NNMQDTYGQE DIFDLLTGSD ATASSVRPVE KNLPEKNEYI LALNVSVNNK KFNDAEAKAK 180
  181 RFLDYVRELE SF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 39.39794
Match: 1c4tA_
Description: Dihydrolipoamide succinyltransferase
Matching Structure (courtesy of the PDB):

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