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View Structure Prediction Details

Protein: PRE9
Organism: Saccharomyces cerevisiae
Length: 258 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PRE9.

Description E-value Query
Range
Subject
Range
PSA4_SPIOL - Proteasome subunit alpha type-4 OS=Spinacia oleracea GN=PAC1 PE=2 SV=1
2.0E-82 [3..250] [2..248]
PSA4A_ARATH - Proteasome subunit alpha type-4-A OS=Arabidopsis thaliana GN=PAC1 PE=1 SV=1
5.0E-82 [3..250] [2..248]
PSA4C_ORYSJ, PSA... - Proteasome subunit alpha type-4-3 OS=Oryza sativa subsp. japonica GN=Os06g0177100 PE=3 SV=1, Proteas...
PSA4A_ORYSA, PSA... - (Q9LE92) Proteasome subunit alpha type 4 (EC 3.4.25.1) (20S proteasome alpha subunit C) (20S proteas...
PSA4A_ORYSI - Proteasome subunit alpha type-4-1 OS=Oryza sativa subsp. indica GN=OsI_021120 PE=1 SV=2
7.0E-82 [3..250] [2..249]
PSA4_PETHY - Proteasome subunit alpha type-4 OS=Petunia hybrida GN=PAC1 PE=2 SV=1
1.0E-81 [3..251] [2..248]
PSA4B_ORYSI - Proteasome subunit alpha type-4-2 OS=Oryza sativa subsp. indica GN=OsI_021067 PE=1 SV=1
PSA4B_ORYSJ - Proteasome subunit alpha type-4-2 OS=Oryza sativa subsp. japonica GN=Os06g0167600 PE=2 SV=1
PSA4B_ORYSA - Proteasome subunit alpha type 4-2 (EC 3.4.25.1) (20S proteasome alpha subunit C) (20S proteasome sub...
2.0E-81 [3..250] [2..249]
gi|286250 - gi|286250|dbj|BAA01587.1| proteasome subunit R-IOTA [Rattus sp.]
gi|67969980 - gi|67969980|dbj|BAE01337.1| unnamed protein product [Macaca fascicularis]
PSMA6 - proteasome (prosome, macropain) subunit, alpha type, 6
PSA6_BOVIN - Proteasome subunit alpha type-6 OS=Bos taurus GN=PSMA6 PE=1 SV=1
gi|55640605, gi|... - gi|55640605|ref|XP_509906.1| PREDICTED: proteasome alpha 6 subunit isoform 6 [Pan troglodytes], gi|1...
gi|109083327, gi... - gi|109083327|ref|XP_001086524.1| PREDICTED: similar to Proteasome subunit alpha type 6 (Proteasome i...
gi|149692835 - gi|149692835|ref|XP_001491320.1| PREDICTED: similar to proteasome alpha 6 subunit [Equus caballus]
ENSOCUP000000134... - pep:novel chromosome:oryCun2:17:55028440:55047757:1 gene:ENSOCUG00000015635 transcript:ENSOCUT000000...
PSA6_RAT - Proteasome subunit alpha type-6 OS=Rattus norvegicus GN=Psma6 PE=1 SV=1
gi|123983062 - gi|123983062|gb|ABM83272.1| proteasome (prosome, macropain) subunit, alpha type, 6 [synthetic constr...
gi|222154129 - gi|222154129|gb|ACM47241.1| proteasome subunit alpha type 6 [Capra hircus]
tr|M3WV20|M3WV20... - Proteasome subunit alpha type OS=Felis catus GN=PSMA6 PE=3 SV=1
3.0E-80 [2..245] [5..245]
gi|6984140 - gi|6984140|gb|AAF34770.1|AF227625_1 proteasome 27 kDa subunit [Euphorbia esula]
3.0E-80 [10..250] [1..240]
PSA6_MOUSE - Proteasome subunit alpha type-6 OS=Mus musculus GN=Psma6 PE=1 SV=1
2.0E-79 [2..245] [5..245]
PSA_PYRAB - Proteasome subunit alpha OS=Pyrococcus abyssi (strain GE5 / Orsay) GN=psmA PE=3 SV=1
PSMA_PYRAB - Proteasome subunit alpha OS=Pyrococcus abyssi GN=psmA PE=3 SV=1
6.0E-79 [4..239] [8..234]

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Predicted Domain #1
Region A:
Residues: [1-258]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGSRRYDSRT TIFSPEGRLY QVEYALESIS HAGTAIGIMA SDGIVLAAER KVTSTLLEQD  60
   61 TSTEKLYKLN DKIAVAVAGL TADAEILINT ARIHAQNYLK TYNEDIPVEI LVRRLSDIKQ 120
  121 GYTQHGGLRP FGVSFIYAGY DDRYGYQLYT SNPSGNYTGW KAISVGANTS AAQTLLQMDY 180
  181 KDDMKVDDAI ELALKTLSKT TDSSALTYDR LEFATIRKGA NDGEVYQKIF KPQEIKDILV 240
  241 KTGITKKDED EEADEDMK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1378.221849
Match: 1fntC_
Description: CRYSTAL STRUCTURE OF THE 20S PROTEASOME FROM YEAST IN COMPLEX WITH THE PROTEASOME ACTIVATOR PA26 FROM TRYPANOSOME BRUCEI AT 3.2 ANGSTROMS RESOLUTION
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
endopeptidase activity 6.91642761177919 bayes_pls_golite062009
peptidase activity 6.84511694091156 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 6.5973571808298 bayes_pls_golite062009
hydrolase activity 4.47652590304822 bayes_pls_golite062009
threonine-type endopeptidase activity 2.98214579292788 bayes_pls_golite062009
threonine-type peptidase activity 2.98214579292788 bayes_pls_golite062009
catalytic activity 1.19663085909195 bayes_pls_golite062009
binding 0.982918122186083 bayes_pls_golite062009
nucleic acid binding 0.448212653390607 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle